{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T19:58:41Z","timestamp":1790366321592,"version":"4.1.0"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2017,5,1]]},"DOI":"10.1093\/jnen\/nlx025","type":"journal-article","created":{"date-parts":[[2017,5,16]],"date-time":"2017-05-16T17:06:57Z","timestamp":1494954417000},"page":"402-413","source":"Crossref","is-referenced-by-count":66,"title":["Clinical Significance of TDP-43 Neuropathology in Amyotrophic Lateral Sclerosis"],"prefix":"10.1093","volume":"76","author":[{"given":"Matthew D.","family":"Cykowski","sequence":"first","affiliation":[{"name":"From the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX (MDC, SZP, ALR, HT); Houston Methodist Neurological Institute, Houston Methodist Hospital, Houston, Texas (SZP, JWA, ALR, HT, SHA); Center for Biostatistics, Houston Methodist Research Institute, Houston, Texas (LP); Stanley H. Appel Department of Neurology, Houston Methodist Hospital, Houston, Texas (J"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne Z.","family":"Powell","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX (MDC, SZP, ALR, HT); Houston Methodist Neurological Institute, Houston Methodist Hospital, Houston, Texas (SZP, JWA, ALR, HT, SHA); Center for Biostatistics, Houston Methodist Research Institute, Houston, Texas (LP); Stanley H. Appel Department of Neurology, Houston Methodist Hospital, Houston, Texas (J"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leif E.","family":"Peterson","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX (MDC, SZP, ALR, HT); Houston Methodist Neurological Institute, Houston Methodist Hospital, Houston, Texas (SZP, JWA, ALR, HT, SHA); Center for Biostatistics, Houston Methodist Research Institute, Houston, Texas (LP); Stanley H. Appel Department of Neurology, Houston Methodist Hospital, Houston, Texas (J"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan W.","family":"Appel","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX (MDC, SZP, ALR, HT); Houston Methodist Neurological Institute, Houston Methodist Hospital, Houston, Texas (SZP, JWA, ALR, HT, SHA); Center for Biostatistics, Houston Methodist Research Institute, Houston, Texas (LP); Stanley H. Appel Department of Neurology, Houston Methodist Hospital, Houston, Texas (J"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreana L.","family":"Rivera","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX (MDC, SZP, ALR, HT); Houston Methodist Neurological Institute, Houston Methodist Hospital, Houston, Texas (SZP, JWA, ALR, HT, SHA); Center for Biostatistics, Houston Methodist Research Institute, Houston, Texas (LP); Stanley H. Appel Department of Neurology, Houston Methodist Hospital, Houston, Texas (J"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hidehiro","family":"Takei","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX (MDC, SZP, ALR, HT); Houston Methodist Neurological Institute, Houston Methodist Hospital, Houston, Texas (SZP, JWA, ALR, HT, SHA); Center for Biostatistics, Houston Methodist Research Institute, Houston, Texas (LP); Stanley H. Appel Department of Neurology, Houston Methodist Hospital, Houston, Texas (J"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Chang","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX (MDC, SZP, ALR, HT); Houston Methodist Neurological Institute, Houston Methodist Hospital, Houston, Texas (SZP, JWA, ALR, HT, SHA); Center for Biostatistics, Houston Methodist Research Institute, Houston, Texas (LP); Stanley H. Appel Department of Neurology, Houston Methodist Hospital, Houston, Texas (J"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stanley H.","family":"Appel","sequence":"additional","affiliation":[{"name":"From the Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Houston, TX (MDC, SZP, ALR, HT); Houston Methodist Neurological Institute, Houston Methodist Hospital, Houston, Texas (SZP, JWA, ALR, HT, SHA); Center for Biostatistics, Houston Methodist Research Institute, Houston, Texas (LP); Stanley H. Appel Department of Neurology, Houston Methodist Hospital, Houston, Texas (J"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,5,16]]},"reference":[{"key":"key\n\t\t\t\t20180315051314_nlx025-B1","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.expneurol.2014.07.021","article-title":"Focality, stochasticity and neuroanatomic propagation in ALS pathogenesis","volume":"262","author":"Ravits","year":"2014","journal-title":"Exp Neurol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3109\/21678421.2013.778548","article-title":"Deciphering amyotrophic lateral sclerosis: what phenotype, neuropathology and genetics are telling us about pathogenesis","volume":"14(Suppl. 1)","author":"Ravits","year":"2013","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B3","doi-asserted-by":"crossref","first-page":"252","DOI":"10.3389\/fnins.2014.00252","article-title":"ALS as a distal axonopathy: molecular mechanisms affecting neuromuscular junction stability in the presymptomatic stages of the disease","volume":"8","author":"Moloney","year":"2014","journal-title":"Front Neurosci"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B4","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1002\/mus.880170708","article-title":"Decremental motor responses to repetitive nerve stimulation in ALS","volume":"17","author":"Killian","year":"1994","journal-title":"Muscle Nerve"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B5","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1212\/01.wnl.0000172911.39167.b6","article-title":"Prevalence and patterns of cognitive impairment in sporadic ALS","volume":"65","author":"Ringholz","year":"2005","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B6","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1212\/01.wnl.0000277422.11236.2c","article-title":"Cognitive impairment in familial ALS","volume":"69","author":"Wheaton","year":"2007","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B7","doi-asserted-by":"crossref","first-page":"542","DOI":"10.3109\/17482968.2010.482592","article-title":"A decrease in body mass index is associated with faster progression of motor symptoms and shorter survival in ALS","volume":"11","author":"Jawaid","year":"2010","journal-title":"Amyotroph Lateral Scler"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B8","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/01.wco.0000183114.76056.0e","article-title":"Autonomic impairment in amyotrophic lateral sclerosis","volume":"18","author":"Baltadzhieva","year":"2005","journal-title":"Curr Opin Neurol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B9","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1002\/mds.23200","article-title":"Parkinsonism and motor neuron diseases: twenty-seven patients with diverse overlap syndromes","volume":"25","author":"Gilbert","year":"2010","journal-title":"Mov Disord"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1001\/archneur.66.1.121","article-title":"Amyotrophic lateral sclerosis-plus syndrome with TAR DNA-binding protein-43 pathology","volume":"66","author":"McCluskey","year":"2009","journal-title":"Arch Neurol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss6508a1","article-title":"Prevalence of amyotrophic lateral sclerosis\u2014United States, 2012\u20132013","volume":"65","author":"Mehta","year":"2016","journal-title":"MMWR Surveill Summ"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B12","doi-asserted-by":"crossref","first-page":"310","DOI":"10.3109\/17482960802566824","article-title":"Prognostic factors in ALS: a critical review","volume":"10","author":"Chio","year":"2009","journal-title":"Amyotroph Lateral Scler"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B13","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1136\/jnnp-2012-303507","article-title":"Cognitive decline and reduced survival in C9orf72 expansion frontotemporal degeneration and amyotrophic lateral sclerosis","volume":"84","author":"Irwin","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B14","doi-asserted-by":"crossref","first-page":"E4968","DOI":"10.1073\/pnas.1315438110","article-title":"RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia","volume":"110","author":"Zu","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B15","doi-asserted-by":"crossref","first-page":"2548","DOI":"10.1172\/JCI82693","article-title":"Emerging mechanisms of molecular pathology in ALS","volume":"125","author":"Peters","year":"2015","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B16","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1016\/S1474-4422(10)70195-2","article-title":"TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia","volume":"9","author":"Mackenzie","year":"2010","journal-title":"Lancet Neurol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B17","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nature20413","article-title":"Decoding ALS: from genes to mechanism","volume":"539","author":"Taylor","year":"2016","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B18","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.neuron.2010.07.019","article-title":"Misfolded mutant SOD1 directly inhibits VDAC1 conductance in a mouse model of inherited ALS","volume":"67","author":"Israelson","year":"2010","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B19","doi-asserted-by":"crossref","first-page":"6569","DOI":"10.1523\/JNEUROSCI.21-17-06569.2001","article-title":"Recruitment of the mitochondrial-dependent apoptotic pathway in amyotrophic lateral sclerosis","volume":"21","author":"Guegan","year":"2001","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B20","first-page":"731","article-title":"Fragmentation of the Golgi apparatus of motor neurons in amyotrophic lateral sclerosis","volume":"140","author":"Gonatas","year":"1992","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B21","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/00005072-198409000-00001","article-title":"Fine structural observations of neurofilamentous changes in amyotrophic lateral sclerosis","volume":"43","author":"Hirano","year":"1984","journal-title":"J Neuropathol Exp Neurol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B22","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1056\/NEJM199205283262204","article-title":"Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis","volume":"326","author":"Rothstein","year":"1992","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B23","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/ana.410380114","article-title":"Selective loss of glial glutamate transporter GTL-1 in amyotrophic lateral sclerosis","volume":"38","author":"Rothstein","year":"1995","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B24","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1172\/JCI71601","article-title":"Emerging mechanisms of molecular pathology in ALS","volume":"125","author":"Peters","year":"2015","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B25","first-page":"4","article-title":"The microglial-motoneuron dialogue in ALS","volume":"30","author":"Appel","year":"2011","journal-title":"Acta Myol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B26","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1002\/emmm.201201544","article-title":"Regulatory T-lymphocytes mediate amyotrophic lateral sclerosis progression and survival","volume":"5","author":"Henkel","year":"2013","journal-title":"EMBO Mol Med"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B27","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/s13311-014-0329-3","article-title":"Protective and toxic neuroinflammation in amyotrophic lateral sclerosis","volume":"12","author":"Hooten","year":"2015","journal-title":"Neurotherapeutics"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B28","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1002\/ana.21147","article-title":"Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations","volume":"61","author":"Mackenzie","year":"2007","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B29","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1002\/ana.23937","article-title":"Stages of pTDP-43 pathology in amyotrophic lateral sclerosis","volume":"74","author":"Brettschneider","year":"2013","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B30","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/nrneurol.2013.221","article-title":"Amyotrophic lateral sclerosis \u2013 a model of corticofugal axonal spread","volume":"9","author":"Braak","year":"2013","journal-title":"Nat Rev Neurol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B31","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1093\/jnen\/nlw014","article-title":"Hippocampal sclerosis but not normal aging or Alzheimer disease is associated with TDP-43 pathology in the basal forebrain of aged persons","volume":"75","author":"Cykowski","year":"2016","journal-title":"J Neuropathol Exp Neurol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B32","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1093\/jnen\/nlw033","article-title":"\u201cNew old pathologies\u201d: AD, PART, and cerebral age-related TDP-43 with sclerosis (CARTS)","volume":"75","author":"Nelson","year":"2016","journal-title":"J Neuropathol Exp Neurol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B33","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00401-014-1269-z","article-title":"TDP-43 is a key player in the clinical features associated with Alzheimer's disease","volume":"127","author":"Josephs","year":"2014","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B34","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1093\/brain\/awr365","article-title":"Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72","volume":"135","author":"Cooper-Knock","year":"2012","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B35","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/ana.410220308","article-title":"A rating scale for amyotrophic lateral sclerosis: description and preliminary experience","volume":"22","author":"Appel","year":"1987","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B36","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1186\/s40478-014-0171-1","article-title":"TDP-43 pathology in the basal forebrain and hypothalamus of patients with amyotrophic lateral sclerosis","volume":"2","author":"Cykowski","year":"2014","journal-title":"Acta Neuropathol Commun"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00401-011-0910-3","article-title":"National Institute on Aging-Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease: a practical approach","volume":"123","author":"Montine","year":"2012","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B38","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00401-015-1515-z","article-title":"The first NINDS\/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy","volume":"131","author":"McKee","year":"2016","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B39","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00401-014-1299-6","article-title":"TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord","volume":"128","author":"Brettschneider","year":"2014","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B40","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1007\/s00401-012-0970-z","article-title":"Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion","volume":"123","author":"Brettschneider","year":"2012","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B41","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s00401-013-1232-4","article-title":"The neuropathology associated with repeat expansions in the C9ORF72 gene","volume":"127","author":"Mackenzie","year":"2014","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B42","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s00401-011-0907-y","article-title":"Clinical and neuropathologic heterogeneity of c9FTD\/ALS associated with hexanucleotide repeat expansion in C9ORF72","volume":"122","author":"Murray","year":"2011","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B43","doi-asserted-by":"crossref","first-page":"3202","DOI":"10.1093\/brain\/aww250","article-title":"Timing and significance of pathological features in C9orf72 expansion-associated frontotemporal dementia","volume":"139","author":"Vatsavayai","year":"2016","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B44","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/nn.4065","article-title":"Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS","volume":"18","author":"Prudencio","year":"2015","journal-title":"Nat Neurosci"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B45","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S1474-4422(08)70071-1","article-title":"TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis","volume":"7","author":"Van Deerlin","year":"2008","journal-title":"Lancet Neurol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B46","doi-asserted-by":"crossref","first-page":"e1000193","DOI":"10.1371\/journal.pgen.1000193","article-title":"Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis","volume":"4","author":"Rutherford","year":"2008","journal-title":"PLoS Genet"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B47","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.bbadis.2009.08.012","article-title":"Mitochondrial dysfunction in amyotrophic lateral sclerosis","volume":"1802","author":"Shi","year":"2010","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.celrep.2014.03.019","article-title":"Intrinsic membrane hyperexcitability of amyotrophic lateral sclerosis patient-derived motor neurons","volume":"7","author":"Wainger","year":"2014","journal-title":"Cell Rep"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B49","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00401-007-0234-5","article-title":"TDP-43 in differential diagnosis of motor neuron disorders","volume":"114","author":"Dickson","year":"2007","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B50","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1017\/S0317167100001505","article-title":"Progress in clinical neurosciences: the evidence for ALS as a multisystems disorder of limited phenotypic expression","volume":"28","author":"Strong","year":"2001","journal-title":"Can J Neurol Sci"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B51","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1001\/archneur.65.5.636","article-title":"Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis","volume":"65","author":"Geser","year":"2008","journal-title":"Arch Neurol"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B52","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s40478-015-0226-y","article-title":"Spread of pathology in amyotrophic lateral sclerosis: assessment of phosphorylated TDP-43 along axonal pathways","volume":"3","author":"Fatima","year":"2015","journal-title":"Acta Neuropathol Commun"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B53","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1126\/science.1134108","article-title":"Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"314","author":"Neumann","year":"2006","journal-title":"Science"},{"key":"key\n\t\t\t\t20180315051314_nlx025-B54","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.pneurobio.2011.08.011","article-title":"On the development of markers for pathological TDP-43 in amyotrophic lateral sclerosis with and without dementia","volume":"95","author":"Geser","year":"2011","journal-title":"Prog Neurobiol"}],"container-title":["Journal of Neuropathology & Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jnen\/article-pdf\/76\/5\/402\/24368951\/nlx025.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,9,24]],"date-time":"2019-09-24T18:35:11Z","timestamp":1569350111000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article\/76\/5\/402\/3797268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5,1]]},"references-count":54,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2017,5,16]]},"published-print":{"date-parts":[[2017,5,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jnen\/nlx025","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"value":"0022-3069","type":"print"},{"value":"1554-6578","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2017,5]]},"published":{"date-parts":[[2017,5,1]]}}}