{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T00:59:56Z","timestamp":1781657996848,"version":"3.54.5"},"reference-count":54,"publisher":"Oxford University Press (OUP)","issue":"1","funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005339","name":"American Academy of Neurology\/American Brain Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005339","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005331","name":"American Brain Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005331","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000913","name":"James S. McDonnell Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000913","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000135","name":"NIH Blueprint for Neuroscience Research","doi-asserted-by":"publisher","award":["5U01-MH093765"],"award-info":[{"award-number":["5U01-MH093765"]}],"id":[{"id":"10.13039\/100000135","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,1,1]]},"DOI":"10.1093\/jnen\/nlx101","type":"journal-article","created":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T15:28:07Z","timestamp":1510846087000},"page":"50-63","source":"Crossref","is-referenced-by-count":84,"title":["Dementia After Moderate-Severe Traumatic Brain Injury: Coexistence of Multiple Proteinopathies"],"prefix":"10.1093","volume":"77","author":[{"given":"Kimbra","family":"Kenney","sequence":"first","affiliation":[{"name":"Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Iacono","sequence":"additional","affiliation":[{"name":"Department of Neurology"},{"name":"Department of Pathology, F. Edward H\u00e9bert School of Medicine"},{"name":"Center for Neuroscience and Regenerative Medicine (CNRM), Uniformed Services University of the Health Sciences (USUHS), Bethesda, Maryland; The Henry M. Jackson Foundation for the Advancement of Military Research"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian L","family":"Edlow","sequence":"additional","affiliation":[{"name":"Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston Massachusetts; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts; Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas I","family":"Katz","sequence":"additional","affiliation":[{"name":"Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston Massachusetts; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts; Department of Neurology"},{"name":"Alzheimer\u2019s Disease Center and CTE Program, Boston University School of Medicine, Boston, Massachusetts; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania;Department of Rehabilitation Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramon","family":"Diaz-Arrastia","sequence":"additional","affiliation":[{"name":"Alzheimer\u2019s Disease Center and CTE Program, Boston University School of Medicine, Boston, Massachusetts; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania;Department of Rehabilitation Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristen","family":"Dams-O\u2019Connor","sequence":"additional","affiliation":[{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai (KDO), New York, New York; Radiological Sciences Laboratory, Department of Radiology, Stanford University (JAM), Stanford, California; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology (BF), Boston, Massachusetts; VA Boston Healthcare System (ACM), Boston, Massachusetts; and Department of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel H","family":"Daneshvar","sequence":"additional","affiliation":[{"name":"Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston Massachusetts; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts; Department of Neurology"},{"name":"Alzheimer\u2019s Disease Center and CTE Program, Boston University School of Medicine, Boston, Massachusetts; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania;Department of Rehabilitation Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison","family":"Stevens","sequence":"additional","affiliation":[{"name":"Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston Massachusetts; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts; Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison L","family":"Moreau","sequence":"additional","affiliation":[{"name":"Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston Massachusetts; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts; Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee S","family":"Tirrell","sequence":"additional","affiliation":[{"name":"Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston Massachusetts; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts; Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ani","family":"Varjabedian","sequence":"additional","affiliation":[{"name":"Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston Massachusetts; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts; Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasia","family":"Yendiki","sequence":"additional","affiliation":[{"name":"Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston Massachusetts; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts; Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"van der Kouwe","sequence":"additional","affiliation":[{"name":"Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston Massachusetts; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts; Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Azma","family":"Mareyam","sequence":"additional","affiliation":[{"name":"Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston Massachusetts; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts; Department of Neurology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer A","family":"McNab","sequence":"additional","affiliation":[{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai (KDO), New York, New York; Radiological Sciences Laboratory, Department of Radiology, Stanford University (JAM), Stanford, California; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology (BF), Boston, Massachusetts; VA Boston Healthcare System (ACM), Boston, Massachusetts; and Department of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wayne A","family":"Gordon","sequence":"additional","affiliation":[{"name":"Alzheimer\u2019s Disease Center and CTE Program, Boston University School of Medicine, Boston, Massachusetts; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania;Department of Rehabilitation Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Fischl","sequence":"additional","affiliation":[{"name":"Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston Massachusetts; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts; Department of Neurology"},{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai (KDO), New York, New York; Radiological Sciences Laboratory, Department of Radiology, Stanford University (JAM), Stanford, California; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology (BF), Boston, Massachusetts; VA Boston Healthcare System (ACM), Boston, Massachusetts; and Department of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann C","family":"McKee","sequence":"additional","affiliation":[{"name":"Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston Massachusetts; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts; Department of Neurology"},{"name":"Department of Neurology, Icahn School of Medicine at Mount Sinai (KDO), New York, New York; Radiological Sciences Laboratory, Department of Radiology, Stanford University (JAM), Stanford, California; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology (BF), Boston, Massachusetts; VA Boston Healthcare System (ACM), Boston, Massachusetts; and Department of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel P","family":"Perl","sequence":"additional","affiliation":[{"name":"Department of Pathology, F. Edward H\u00e9bert School of Medicine"},{"name":"Center for Neuroscience and Regenerative Medicine (CNRM), Uniformed Services University of the Health Sciences (USUHS), Bethesda, Maryland; The Henry M. Jackson Foundation for the Advancement of Military Research"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2017,11,16]]},"reference":[{"key":"key\n\t\t\t\t20180803092121_nlx101-B1","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1212\/WNL.55.8.1158","article-title":"Documented head injury in early adulthood and risk of Alzheimer\u2019s disease and other dementias","volume":"55","author":"Plassman","year":"2000","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1212\/01.wnl.0000194264.60150.d3","article-title":"Longitudinal cognitive changes in traumatic brain injury: a 30-year follow-up study","volume":"66","author":"Himanen","year":"2006","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B3","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1136\/jnnp.74.7.857","article-title":"Head injury as a risk factor for Alzheimer\u2019s disease: the evidence 10 years on; a partial replication","volume":"74","author":"Fleminger","year":"2003","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B4","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1093\/oxfordjournals.aje.a009290","article-title":"Head injury and risk of Alzheimer\u2019s disease by apolipoprotein E genotype","volume":"146","author":"O'Meara","year":"1997","journal-title":"Am J Epidemiol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B5","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1212\/WNL.53.9.1959","article-title":"Head trauma and risk of dementia and Alzheimer\u2019s disease: the Rotterdam study","volume":"53","author":"Mehta","year":"1999","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B6","first-page":"889","article-title":"Apolipoprotein-epsilon4 and head trauma: Synergistic or additive risks?","volume":"46","author":"Katzman","year":"1996","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B7","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1212\/WNL.45.3.555","article-title":"Synergistic effects of traumatic head injury and apolipoprotein-epsilon 4 in patients with Alzheimer\u2019s disease","volume":"45","author":"Mayeux","year":"1995","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B8","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/j.expneurol.2015.06.015","article-title":"Polypathology and dementia after brain trauma: Does brain injury trigger distinct neurodegenerative diseases, or should they be classified together as traumatic encephalopathy?","volume":"275","author":"Washington","year":"2016","journal-title":"Exp Neurol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B9","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1001\/jamaneurol.2014.2668","article-title":"Dementia risk after traumatic brain injury vs. nonbrain trauma: the role of age and severity","volume":"71","author":"Gardner","year":"2014","journal-title":"JAMA Neurol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B10","doi-asserted-by":"crossref","first-page":"985","DOI":"10.3233\/JAD-143207","article-title":"Prevalence of traumatic brain injury in early versus late-onset Alzheimer\u2019s disease","volume":"47","author":"Mendez","year":"2015","journal-title":"J Alzheimers Dis"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B11","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1089\/neu.2012.2638","article-title":"Clinical phenotype of dementia after traumatic brain injury","volume":"31","author":"Sayed","year":"2013","journal-title":"J Neurotrauma"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B12","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3233\/NRE-130838","article-title":"An exploration of clinical dementia phenotypes among individuals with and without traumatic brain injury","volume":"32","author":"Dams-O\u2019Connor","year":"2013","journal-title":"Neurorehabilitation"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1002\/ana.410250402","article-title":"Development of dementing illnesses in an 80-year-old volunteer cohort","volume":"25","author":"Katzman","year":"1989","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B14","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1002\/ana.410330306","article-title":"Risk factors for late-onset Alzheimer\u2019s diease: a population-based, case-control study","volume":"33","author":"Fratiglioni","year":"1993","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B15","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1017\/S104161029700447X","article-title":"Risk factors for clinically diagnosed Alzheimer\u2019s disease: a case-control study of a Greek population","volume":"9","author":"Tsolaki","year":"1997","journal-title":"Int Psychogeriatr"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B16","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1136\/jnnp-2015-311438","article-title":"Traumatic brain injury history is associated with earlier age of onset of frontotemporal dementia","volume":"87","author":"LoBue","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jalz.2017.04.010","article-title":"Head or brain injuries and Alzheimer\u2019s disease: a nested case-control register study","author":"Tolppanen","year":"2017","journal-title":"Alzheimers Dement"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B18","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1136\/jnnp-2012-303938","article-title":"Risk for late-life re-injury, dementia and death among individuals with traumatic brain injury: a population-based study","volume":"84","author":"Dams-O\u2019Connor","year":"2013","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B19","doi-asserted-by":"crossref","first-page":"S28","DOI":"10.1093\/ije\/20.Supplement_2.S28","article-title":"Head trauma as a risk factor for Alzheimer\u2019s disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group","volume":"20 Suppl 2","author":"Mortimer","year":"1991","journal-title":"Int J Epidemiol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/ana.20882","article-title":"Head injury and Parkinson's disease risk in twins","volume":"60","author":"Goldman","year":"2006","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B21","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1093\/aje\/kwm153","article-title":"Head injury and amyotrophic lateral sclerosis","volume":"166","author":"Chen","year":"2007","journal-title":"Am J Epidemiol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B22","author":"Kenney","year":"2014"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B23","author":"Daneshvar","year":"2013"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B24","doi-asserted-by":"crossref","first-page":"97.e7","DOI":"10.1016\/j.genhosppsych.2014.09.016","article-title":"A case of Alzheimer\u2019s disease following mild traumatic brain injury","volume":"37","author":"Tateno","year":"2015","journal-title":"Gen Hosp Psychiatry"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B25","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s00401-011-0909-9","article-title":"Acute and chronically increased immunoreactivity to phosphorylation-independent but not pathological TDP-43 after a single traumatic brain injury in humans","volume":"122","author":"Johnson","year":"2011","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B26","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1212\/WNL.41.4.479","article-title":"The Consortium to Establish a Registry for Alzheimer\u2019s disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer\u2019s disease","volume":"41","author":"Mirra","year":"1991","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B27","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B28","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1002\/ana.20426","article-title":"Detection of entorhinal layer II using 7 Tesla magnetic resonance imaging","volume":"57","author":"Augustinack","year":"2005","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B29","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/j.neuroimage.2004.07.016","article-title":"Sequence-independent segmentation of magnetic resonance images","volume":"23","author":"Fischl","year":"2004","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B30","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1097\/NEN.0b013e3182945bf6","article-title":"Disconnection of the ascending arousal system in traumatic coma","volume":"72","author":"Edlow","year":"2013","journal-title":"J Neuropathol Exp Neurol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B31","year":"2016"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B32","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00401-015-1515-z","article-title":"The first NINDS\/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy","volume":"131","author":"McKee","year":"2016","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B33","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF00304630","article-title":"Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer\u2019s disease cases","volume":"85","author":"Hof","year":"1992","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B34","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1093\/brain\/aws307","article-title":"The spectrum of disease in chronic traumatic encephalopathy","volume":"136","author":"McKee","year":"2013","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B35","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1126\/science.1134108","article-title":"Ubiquitinated TDP-43in frontotemporal lobar degeneration and amyotrophic lateral sclerosis","volume":"314","author":"Neumann","year":"2006","journal-title":"Science"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B36","first-page":"608","article-title":"TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy","volume":"92","author":"McKee","year":"2010","journal-title":"J Neuropath Exp Neurol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B37","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.brainres.2009.07.023","article-title":"Cytsolic TDP-43 expression following axotomy is associated with caspase 3 activation in NFL-I-mice: support for a role for TDP-re in the physiological response to neuronal injury","volume":"1296","author":"Moisse","year":"2009","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B38","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1016\/j.neuron.2012.11.021","article-title":"The neuropathology and neurobiology of traumatic brain injury","volume":"76","author":"Blennow","year":"2012","journal-title":"Neuron"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B39","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1093\/jnen\/nlw002","article-title":"Altered proteins in the aging brain","volume":"75","author":"Elobeid","year":"2016","journal-title":"J Neuropathol Exp Neurol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B40","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1002\/ana.24493","article-title":"TDP-re and pathological subtype of Alzheimer\u2019s disease impact clinical features","volume":"78","author":"Josephs","year":"2015","journal-title":"Ann Neurol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B41","doi-asserted-by":"crossref","first-page":"10083","DOI":"10.1523\/JNEUROSCI.22-23-10083.2002","article-title":"Apolipoprotein e4 influences amyloid deposition but not cell loss after traumatic brain injury in a mouse model of Alzheimer\u2019s disease","volume":"22","author":"Hartman","year":"2002","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B42","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1001\/jamaneurol.2013.600","article-title":"APOE \u025b4 increases risk for dementia in pure synucleinopathies","volume":"70","author":"Tsuang","year":"2013","journal-title":"JAMA Neurol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B43","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1080\/13554794.2012.667124","article-title":"ApoE and TD-43 neuropathology in two siblings with familial FTLD-motor neuron disease","volume":"19","author":"Vossel","year":"2013","journal-title":"Neurocase"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B44","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1093\/brain\/aws322","article-title":"Inflammation and white matter degeneration persist for years after a single traumatic brain injury","volume":"136","author":"Johnson","year":"2013","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B45","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.tins.2016.03.002","article-title":"Traumatic axonal injury: mechanisms and translational opportunities","volume":"39","author":"Hill","year":"2016","journal-title":"Trends Neurosci"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B46","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1001\/jamaneurol.2016.1948","article-title":"Association of traumatic brain injury with late-life neurodegenerative conditions and neuropathologic findings","volume":"73","author":"Crane","year":"2016","journal-title":"JAMA Neurol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B47","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-2377-1-3","article-title":"Traumatic brain injury as a risk factor for Alzheimer disease. Comparison of two retrospective autopsy cohorts with evaluation of ApoE genotype","volume":"1","author":"Jellinger","year":"2001","journal-title":"BMC Neurol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B48","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s00401-015-1502-4","article-title":"Chronic traumatic encephalopathy pathology in a neurodegenerative disorders brain bank","volume":"130","author":"Bieniek","year":"2015","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B49","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1750-3639.2011.00513.x","article-title":"Widespread tau and amyloid-beta pathology many years after a single traumatic brain injury in humans","volume":"22","author":"Johnson","year":"2012","journal-title":"Brain Pathol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B50","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.expneurol.2004.06.011","article-title":"Alzheimer\u2019s pathology in human temporal cortex surgically excised after severe brain injury","volume":"190","author":"Ikonomovic","year":"2004","journal-title":"Exp Neurol"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B51","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.brainres.2010.12.077","article-title":"The neuroprotective domains of the amyloid precursor protein, in traumatic brain injury, are located in the two growth factor domains","volume":"1378","author":"Corrigan","year":"2011","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B52","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1385\/NMM:4:1-2:59","article-title":"Protein accumulation in traumatic brain injury","volume":"4","author":"Smith","year":"2003","journal-title":"Neuromolecular Med"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B53","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1212\/WNL.0000000000002413","article-title":"Amyloid pathology and axonal injury after brain trauma","volume":"86","author":"Scott","year":"2016","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180803092121_nlx101-B54","first-page":"1147","article-title":"Blood-brain disruption is an early event that may persist for many years after traumatic brain injury in humans","volume":"74","author":"Hay","year":"2015","journal-title":"J Neuropathol Exp Neurol"}],"container-title":["Journal of Neuropathology &amp; Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jnen\/article-pdf\/77\/1\/50\/25422641\/nlx101.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T23:46:14Z","timestamp":1603323974000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article\/77\/1\/50\/4636788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11,16]]},"references-count":54,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2017,11,16]]},"published-print":{"date-parts":[[2018,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jnen\/nlx101","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"value":"0022-3069","type":"print"},{"value":"1554-6578","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,1]]},"published":{"date-parts":[[2017,11,16]]}}}