{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T08:31:08Z","timestamp":1773304268233,"version":"3.50.1"},"reference-count":87,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2018,1,13]],"date-time":"2018-01-13T00:00:00Z","timestamp":1515801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/academic.oup.com\/journals\/pages\/about_us\/legal\/notices"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["NIH-R01-NS-096087"],"award-info":[{"award-number":["NIH-R01-NS-096087"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-NS-063967"],"award-info":[{"award-number":["R01-NS-063967"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P40-OD-010939"],"award-info":[{"award-number":["P40-OD-010939"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32-NS-007222"],"award-info":[{"award-number":["T32-NS-007222"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001790","name":"Ara Parseghian Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001790","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Dana's Angels Research Trust"},{"name":"Race for Adam"},{"DOI":"10.13039\/100003181","name":"National Niemann-Pick Disease Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100003181","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Support of Accelerated Research for Niemann Pick Type C disease (SOAR-NPC)"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,3,1]]},"DOI":"10.1093\/jnen\/nlx119","type":"journal-article","created":{"date-parts":[[2018,1,13]],"date-time":"2018-01-13T08:42:20Z","timestamp":1515832940000},"page":"229-245","source":"Crossref","is-referenced-by-count":8,"title":["LC3 Immunostaining in the Inferior Olivary Nuclei of Cats With Niemann-Pick Disease Type C1 Is Associated With Patterned Purkinje Cell Loss"],"prefix":"10.1093","volume":"77","author":[{"given":"Brittney L","family":"Gurda","sequence":"first","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica H","family":"Bagel","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samantha J","family":"Fisher","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark L","family":"Schultz","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew P","family":"Lieberman","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Michigan Medical School, Ann Arbor, Michigan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Hand","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles H","family":"Vite","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary P","family":"Swain","sequence":"additional","affiliation":[{"name":"Department of Clinical Sciences and Advanced Medicine, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,1,13]]},"reference":[{"key":"key\n\t\t\t\t20180618202328_nlx119-B1","doi-asserted-by":"crossref","first-page":"8247","DOI":"10.1073\/pnas.82.23.8247","article-title":"A defect in cholesterol esterification in Niemann\u2013Pick disease (type C) patients","volume":"82","author":"Pentchev","year":"1985","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1034\/j.1399-0004.2003.00147.x","article-title":"Niemann\u2013Pick disease type C","volume":"64","author":"Vanier","year":"2003","journal-title":"Clin Genet"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B3","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/humu.20636","article-title":"NPC-db, a Niemann\u2013Pick type C disease gene variation database","volume":"29","author":"Runz","year":"2008","journal-title":"Hum Mutat"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B4","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1093\/jnen\/64.4.323","article-title":"Molecular, anatomical, and biochemical events associated with neurodegeneration in mice with Niemann\u2013Pick type C disease","volume":"64","author":"Li","year":"2005","journal-title":"J Neuropathol Exp Neurol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B5","doi-asserted-by":"crossref","first-page":"15287","DOI":"10.1073\/pnas.0807328105","article-title":"NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes","volume":"105","author":"Infante","year":"2008","journal-title":"Proc Natl Acad Sci Usa U S A"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B6","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.bbalip.2004.08.011","article-title":"Consequences of NPC1 and NPC2 loss of function in mammalian neurons","volume":"1685","author":"Walkley","year":"2004","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B7","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1242\/dmm.012385","article-title":"Genetic dissection of a cell-autonomous neurodegenerative disorder: Lessons learned from mouse models of Niemann\u2013Pick disease type C","volume":"6","author":"Lopez","year":"2013","journal-title":"Dis Model Mech"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B8","first-page":"81","article-title":"Cell-autonomous death of cerebellar Purkinje neurons with autophagy in Niemann\u2013Pick type C disease","volume":"1","author":"Ko","year":"2005","journal-title":"PLoS Genet"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B9","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1093\/hmg\/ddp552","article-title":"Conditional Niemann\u2013Pick C mice demonstrate cell autonomous Purkinje cell neurodegeneration","volume":"19","author":"Elrick","year":"2010","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B10","doi-asserted-by":"crossref","first-page":"4440","DOI":"10.1093\/hmg\/ddr372","article-title":"Temporal and cell-specific deletion establishes that neuronal Npc1 deficiency is sufficient to mediate neurodegeneration","volume":"20","author":"Yu","year":"2011","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B11","doi-asserted-by":"crossref","first-page":"4367","DOI":"10.1523\/JNEUROSCI.5981-10.2011","article-title":"Anatomically defined neuron-based rescue of neurodegenerative Niemann\u2013Pick type C disorder","volume":"31","author":"Lopez","year":"2011","journal-title":"J Neurosci"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B12","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1093\/hmg\/ddm100","article-title":"Autophagy in Niemann\u2013Pick C disease is dependent upon Beclin-1 and responsive to lipid trafficking defects","volume":"16","author":"Pacheco","year":"2007","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B13","doi-asserted-by":"crossref","first-page":"962","DOI":"10.2353\/ajpath.2007.070052","article-title":"Cholesterol accumulation is associated with lysosomal dysfunction and autophagic stress in Npc1\u2212\/\u2212 mouse brain","volume":"171","author":"Liao","year":"2007","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B14","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1146\/annurev-biochem-060815-014556","article-title":"Mammalian autophagy: How does it work?","volume":"85","author":"Bento","year":"2016","journal-title":"Annu Rev Biochem"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B15","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.jmb.2017.01.002","article-title":"Autophagosome Maturation and Fusion","volume":"429","author":"Reggiori","year":"2017","journal-title":"J Mol Biol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B16","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1083\/jcb.201106120","article-title":"Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons","volume":"196","author":"Maday","year":"2012","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B17","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1007\/s12264-015-1536-6","article-title":"Autophagy in synaptic development, function, and pathology","volume":"31","author":"Shen","year":"2015","journal-title":"Neurosci Bull"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B18","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s00401-014-1361-4","article-title":"Autophagy in neuronal cells: General principles and physiological and pathological functions","volume":"129","author":"Damme","year":"2015","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B19","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/cdd.2014.204","article-title":"Autophagy in the physiology and pathology of the central nervous system","volume":"22","author":"Nikoletopoulou","year":"2015","journal-title":"Cell Death Differ"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S1096-7192(03)00074-X","article-title":"Mutation analysis of feline Niemann\u2013Pick C1 disease","volume":"79","author":"Somers","year":"2003","journal-title":"Mol Genet Metab"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B21","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1203\/PDR.0b013e318184d2ce","article-title":"Clinical, electrophysiological, and serum biochemical measures of progressive neurological and hepatic dysfunction in feline Niemann\u2013Pick type C disease","volume":"64","author":"Vite","year":"2008","journal-title":"Pediatr Res"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B22","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/BF00334507","article-title":"Feline sphingolipidosis resembling Niemann\u2013Pick disease type C","volume":"81","author":"Lowenthal","year":"1990","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B23","first-page":"1412","article-title":"Feline Niemann\u2013Pick disease type C","volume":"144","author":"Brown","year":"1994","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1939-1676.1994.tb03208.x","article-title":"Neurological manifestations of Niemann\u2013Pick disease type C in cats","volume":"8","author":"Munana","year":"1994","journal-title":"J Vet Intern Med"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B25","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1007\/s004010050689","article-title":"GABAergic neuroaxonal dystrophy and other cytopathological alterations in feline Niemann\u2013Pick disease type C","volume":"94","author":"March","year":"1997","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B26","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1016\/S0140-6736(17)31465-4","article-title":"Intrathecal 2-hydroxypropyl-beta-cyclodextrin decreases neurological disease progression in Niemann\u2013Pick disease, type C1: A non-randomised, open-label, phase 1\u20132 trial","volume":"390","author":"Ory","year":"2017","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B27","doi-asserted-by":"crossref","first-page":"276ra26","DOI":"10.1126\/scitranslmed.3010101","article-title":"Intracisternal cyclodextrin prevents cerebellar dysfunction and Purkinje cell death in feline Niemann\u2013Pick type C1 disease","volume":"7","author":"Vite","year":"2015","journal-title":"Sci Transl Med"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B28","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/BF00228514","article-title":"Lateral and medial sub-divisions within the olivocerebellar zones of the paravermal cortex in lobule Vb\/c of the cat anterior lobe","volume":"87","author":"Trott","year":"1991","journal-title":"Exp Brain Res"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B29","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0006-8993(77)90105-6","article-title":"Projections from the inferior olive to the cerebellar nuclei in the cat demonstrated by retrograde transport of horseradish peroxidase","volume":"130","author":"Courville","year":"1977","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B30","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/cne.901740304","article-title":"The parasagittal zonation within the olivocerebellar projection. I. Climbing fiber distribution in the vermis of cat cerebellum","volume":"174","author":"Groenewegen","year":"1977","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B31","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1002\/cne.901830307","article-title":"The parasagittal zonation within the olivocerebellar projection. II. Climbing fiber distribution in the intermediate and hemispheric parts of cat cerebellum","volume":"183","author":"Groenewegen","year":"1979","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B32","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/0006-8993(85)90601-8","article-title":"Vestibular afferents of the inferior olive and the vestibulo-olivo-cerebellar climbing fiber pathway to the flocculus in the cat","volume":"332","author":"Gerrits","year":"1985","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B33","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1002\/cne.901660404","article-title":"The olivocerebellar projection in the cat as studied with the method of retrograde axonal transport of horseradish peroxidase. II. The projection to the uvula","volume":"166","author":"Brodal","year":"1976","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B34","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/cne.901760209","article-title":"The olivocerebellar projection in the cat studied with the method of retrograde axonal transport of horseradish peroxidase. VI. The projection onto longitudinal zones of the paramedian lobule","volume":"176","author":"Brodal","year":"1977","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B35","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/cne.901720105","article-title":"The olivocerebellar projection in the cat studied with the method of retrograde axonal transport of horseradish peroxidase. IV. The projection to the anterior lobe","volume":"172","author":"Brodal","year":"1977","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B36","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1086\/302183","article-title":"Spectrum of mutations in \u03b1-mannosidosis","volume":"64","author":"Berg","year":"1999","journal-title":"Am J Hum Genet"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B37","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1093\/jhered\/esg080","article-title":"Inheritance, biochemical abnormalities, and clinical features of feline mucolipidosis II: The first animal model of human I-cell disease","volume":"94","author":"Mazrier","year":"2003","journal-title":"J Hered"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B38","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1006\/geno.1999.5825","article-title":"Molecular basis of feline beta-glucuronidase deficiency: An animal model of mucopolysaccharidosis VII","volume":"58","author":"Fyfe","year":"1999","journal-title":"Genomics"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B39","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/cne.10522","article-title":"Patterned Purkinje cell degeneration in mouse models of Niemann\u2013Pick type C disease","volume":"456","author":"Sarna","year":"2003","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B40","first-page":"1053","article-title":"Untersuchungen uber die Olivocerebellaren Lokalisation","volume":"169","author":"Brodal","year":"1940","journal-title":"Z Neurol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B41","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/cne.900840105","article-title":"The Ponto-Cerebellar Projection in the Rabbit and Cat - Experimental Investigations","volume":"84","author":"Brodal","year":"1946","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B42","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1093\/jnen\/60.8.817","article-title":"Histopathology, electrodiagnostic testing, and magnetic resonance imaging show significant peripheral and central nervous system myelin abnormalities in the cat model of \u03b1-mannosidosis","volume":"60","author":"Vite","year":"2001","journal-title":"J Neuropathol Exp Neurol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B43","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/s12311-010-0221-6","article-title":"Cerebellar zones: A personal history","volume":"10","author":"Voogd","year":"2011","journal-title":"Cerebellum"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B44","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/978-94-007-1333-8_19","volume-title":"Handbook of the Cerebellum and Cerebellar Disorders","author":"Voogd","year":"2013","edition":"1 edn"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/cne.901470102","article-title":"The number of Purkinje cells and inferior olivary neurones in the cat","volume":"147","author":"Mlonyeni","year":"1973","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B46","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1007\/s12311-010-0164-y","article-title":"Ins and outs of cerebellar modules","volume":"10","author":"Ruigrok","year":"2011","journal-title":"Cerebellum"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B47","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0301-0082(93)90048-W","article-title":"The cerebellar olivo-corticonuclear connections in the rat","volume":"40","author":"Buisseret-Delmas","year":"1993","journal-title":"Prog Neurobiol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B48","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1038\/nrn2698","article-title":"Cerebellar cortical organization: A one-map hypothesis","volume":"10","author":"Apps","year":"2009","journal-title":"Nat Rev Neurosci"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B49","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/cne.901610206","article-title":"Projections of the dorsal column nuclei and the spinal cord on the inferior olive in the cat","volume":"161","author":"Boesten","year":"1975","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B50","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0006-8993(78)90406-7","article-title":"Efferent projections of the gracile nucleus in the cat","volume":"153","author":"Berkley","year":"1978","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(90)91314-7","article-title":"Convergent inputs to the inferior olive from the dorsal column nuclei and pretectum in the cat","volume":"525","author":"Bull","year":"1990","journal-title":"Brain Res"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B52","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/cne.902230109","article-title":"Ascending somatosensory projections to the dorsal accessory olive: An anatomical study in cats","volume":"223","author":"Molinari","year":"1984","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B53","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1002\/cne.901800205","article-title":"Projections to the inferior olive of the cat. II. Comparisons of input from the gracile, cuneate and the spinal trigeminal nuclei","volume":"180","author":"Berkley","year":"1978","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B54","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/cne.902410206","article-title":"The trigemino-olivary projection in the cat: Contributions of individual subnuclei","volume":"241","author":"Huerta","year":"1985","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B55","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/B978-0-12-374236-0.10015-X","volume-title":"The Human Nervous System","author":"Voogd","year":"2012","edition":"3 edn."},{"key":"key\n\t\t\t\t20180618202328_nlx119-B56","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/cne.901490107","article-title":"The topographic organization of spinal afferents to the lateral reticular nucleus of the cat","volume":"149","author":"Kunzle","year":"1973","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B57","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1007\/BF00237166","article-title":"The lateral reticular nucleus in the cat. I. Mossy fibre distribution in cerebellar cortex","volume":"21","author":"Clendenin","year":"1974","journal-title":"Exp Brain Res"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B58","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1002\/cne.902010307","article-title":"Projections from the pontine nuclei proper and reticular tegmental nucleus onto the cerebellar cortex in the cat. An autoradiographic study","volume":"201","author":"Kawamura","year":"1981","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B59","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/cne.901790208","article-title":"Spinal projection to the dorsolateral nucleus of the caudal basilar pons in the cat","volume":"179","author":"Ruegg","year":"1978","journal-title":"J Comp Neurol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B60","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/978-94-007-1333-8_48","volume-title":"Handbook of the Cerebellum and Cerebellar Disorders","author":"Apps","year":"2013","edition":"1 ed"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B61","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/nature04724","article-title":"Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice","volume":"441","author":"Hara","year":"2006","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B62","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nature04723","article-title":"Loss of autophagy in the central nervous system causes neurodegeneration in mice","volume":"441","author":"Komatsu","year":"2006","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B63","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1016\/j.bbamcr.2008.12.001","article-title":"Lysosomal disorders: From storage to cellular damage","volume":"1793","author":"Ballabio","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B64","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/1750-1326-4-16","article-title":"All-you-can-eat: Autophagy in neurodegeneration and neuroprotection","volume":"4","author":"Jaeger","year":"2009","journal-title":"Mol Neurodegener"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B65","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1016\/j.bbamcr.2009.01.016","article-title":"The cellular pathways of neuronal autophagy and their implication in neurodegenerative diseases","volume":"1793","author":"Yue","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B66","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/nm.3232","article-title":"The role of autophagy in neurodegenerative disease","volume":"19","author":"Nixon","year":"2013","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B67","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nrn3961","article-title":"Compromised autophagy and neurodegenerative diseases","volume":"16","author":"Menzies","year":"2015","journal-title":"Nat Rev Neurosci"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B68","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1146\/annurev-neuro-070815-014031","article-title":"Brain disorders due to lysosomal dysfunction","volume":"39","author":"Fraldi","year":"2016","journal-title":"Annu Rev Neurosci"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B69","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.bbalip.2016.01.006","article-title":"Autophagy, lipophagy and lysosomal lipid storage disorders","volume":"1861","author":"Ward","year":"2016","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B70","doi-asserted-by":"crossref","first-page":"3607","DOI":"10.1038\/emboj.2010.237","article-title":"Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders","volume":"29","author":"Fraldi","year":"2010","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B71","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/j.celrep.2013.10.042","article-title":"Impaired autophagy in the lipid-storage disorder Niemann\u2013Pick type C1 disease","volume":"5","author":"Sarkar","year":"2013","journal-title":"Cell Rep"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B72","doi-asserted-by":"crossref","first-page":"234","DOI":"10.4161\/auto.22501","article-title":"Autophagic dysfunction in a lysosomal storage disorder due to impaired proteolysis","volume":"9","author":"Elrick","year":"2013","journal-title":"Autophagy"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B73","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.1093\/hmg\/dds324","article-title":"Impaired proteolysis underlies autophagic dysfunction in Niemann\u2013Pick type C disease","volume":"21","author":"Elrick","year":"2012","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B74","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.jocn.2008.09.020","article-title":"Association of autophagy with cholesterol-accumulated compartments in Niemann\u2013Pick disease type C cells","volume":"16","author":"Ishibashi","year":"2009","journal-title":"J Clin Neurosci"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B75","doi-asserted-by":"crossref","first-page":"646","DOI":"10.4161\/auto.5074","article-title":"Autophagic-lysosomal dysfunction and neurodegeneration in Niemann\u2013Pick Type C mice: Lipid starvation or indigestion?","volume":"3","author":"Bi","year":"2007","journal-title":"Autophagy"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B76","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.4161\/auto.20668","article-title":"Defective mitophagy in human Niemann\u2013Pick Type C1 neurons is due to abnormal autophagy activation","volume":"8","author":"Ordonez","year":"2012","journal-title":"Autophagy"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B77","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1093\/hmg\/dds090","article-title":"Disruption and therapeutic rescue of autophagy in a human neuronal model of Niemann Pick type C1","volume":"21","author":"Ordonez","year":"2012","journal-title":"Hum Mol Genet"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B78","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.stemcr.2014.03.014","article-title":"Genetic and chemical correction of cholesterol accumulation and impaired autophagy in hepatic and neural cells derived from Niemann\u2013Pick Type C patient-specific iPS cells","volume":"2","author":"Maetzel","year":"2014","journal-title":"Stem Cell Rep"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B79","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.nbd.2013.12.018","article-title":"The autophagic defect in Niemann\u2013Pick disease type C neurons differs from somatic cells and reduces neuronal viability","volume":"64","author":"Meske","year":"2014","journal-title":"Neurobiol Dis"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B80","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.neuropharm.2014.10.006","article-title":"How to reduce the accumulation of autophagic vacuoles in NPC1-deficient neurons: A comparison of two pharmacological strategies","volume":"89","author":"Meske","year":"2015","journal-title":"Neuropharmacology"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B81","doi-asserted-by":"crossref","first-page":"858","DOI":"10.4161\/auto.20055","article-title":"Autophagosome assembly and cargo capture in the distal axon","volume":"8","author":"Maday","year":"2012","journal-title":"Autophagy"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B82","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.devcel.2014.06.001","article-title":"Autophagosome biogenesis in primary neurons follows an ordered and spatially regulated pathway","volume":"30","author":"Maday","year":"2014","journal-title":"Dev Cell"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B83","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1083\/jcb.201412046","article-title":"Axonal autophagosomes recruit dynein for retrograde transport through fusion with late endosomes","volume":"209","author":"Cheng","year":"2015","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B84","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1080\/15548627.2015.1062203","article-title":"Axonal autophagosomes use the ride-on service for retrograde transport toward the soma","volume":"11","author":"Cheng","year":"2015","journal-title":"Autophagy"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B85","doi-asserted-by":"crossref","first-page":"548","DOI":"10.4161\/auto.5.4.8364","article-title":"Tau normal function influences Niemann\u2013Pick type C disease pathogenesis in mice and modulates autophagy in NPC1-deficient cells","volume":"5","author":"Pacheco","year":"2009","journal-title":"Autophagy"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B86","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/15548627.2017.1329081","article-title":"Methyl-beta-cyclodextrin restores impaired autophagy flux in Niemann\u2013Pick C1-deficient cells through activation of AMPK","volume":"13","author":"Dai","year":"2017","journal-title":"Autophagy"},{"key":"key\n\t\t\t\t20180618202328_nlx119-B87","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.1093\/emboj\/19.21.5720","article-title":"LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing","volume":"19","author":"Kabeya","year":"2000","journal-title":"EMBO J"}],"container-title":["Journal of Neuropathology &amp; Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jnen\/article-pdf\/77\/3\/229\/25052170\/nlx119.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,9]],"date-time":"2019-10-09T06:00:43Z","timestamp":1570600843000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article\/77\/3\/229\/4807505"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,13]]},"references-count":87,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,1,13]]},"published-print":{"date-parts":[[2018,3,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jnen\/nlx119","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"value":"0022-3069","type":"print"},{"value":"1554-6578","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,3]]},"published":{"date-parts":[[2018,1,13]]}}}