{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:20:02Z","timestamp":1783776002377,"version":"3.55.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,4,1]]},"DOI":"10.1093\/jnen\/nly006","type":"journal-article","created":{"date-parts":[[2018,2,12]],"date-time":"2018-02-12T10:37:30Z","timestamp":1518431850000},"page":"302-311","source":"Crossref","is-referenced-by-count":75,"title":["Adult Brainstem Gliomas With H3K27M Mutation: Radiology, Pathology, and Prognosis"],"prefix":"10.1093","volume":"77","author":[{"given":"Elena V","family":"Daoud","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veena","family":"Rajaram","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyu","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J","family":"Oberle","sequence":"additional","affiliation":[{"name":"Department of Radiology, Central Texas Veterans Healthcare System, Temple, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory R","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack M","family":"Raisanen","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Charles L","family":"White","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Foong","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce E","family":"Mickey","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimmo J","family":"Hatanpaa","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,2,10]]},"reference":[{"key":"key\n\t\t\t\t20180315101246_nly006-B1","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/ng.2936","article-title":"Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations","volume":"46","author":"Buczkowicz","year":"2014","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20180315101246_nly006-B2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/path.4813","article-title":"Molecular pathology of paediatric central nervous system tumours","volume":"241","author":"Chiang","year":"2017","journal-title":"J Pathol"},{"key":"key\n\t\t\t\t20180315101246_nly006-B3","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1309\/AJCPABOHBC33FVMO","article-title":"H3F3A K27M mutation in pediatric CNS tumors: A marker for diffuse high-grade astrocytomas","volume":"139","author":"Gielen","year":"2013","journal-title":"Am J Clin Pathol"},{"key":"key\n\t\t\t\t20180315101246_nly006-B4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/ng.1102","article-title":"Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas","volume":"44","author":"Wu","year":"2012","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20180315101246_nly006-B5","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/neuonc\/not144","article-title":"H3F3A K27M mutations in thalamic gliomas from young adult patients","volume":"16","author":"Aihara","year":"2014","journal-title":"Neuro Oncol"},{"key":"key\n\t\t\t\t20180315101246_nly006-B6","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.humpath.2015.07.002","article-title":"The H3.3 K27M mutation results in a poorer prognosis in brainstem gliomas than thalamic gliomas in adults","volume":"46","author":"Feng","year":"2015","journal-title":"Hum Pathol"},{"key":"key\n\t\t\t\t20180315101246_nly006-B7","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00401-015-1463-7","article-title":"High frequency of H3F3A (K27M) mutations characterizes pediatric and adult high-grade gliomas of the spinal cord","volume":"130","author":"Gessi","year":"2015","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180315101246_nly006-B8","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/s00401-012-0998-0","article-title":"K27M mutation in histone H3.3 defines clinically and biologically distinct subgroups of pediatric diffuse intrinsic pontine gliomas","volume":"124","author":"Khuong-Quang","year":"2012","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180315101246_nly006-B9","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s40478-016-0361-0","article-title":"Pilocytic astrocytoma and glioneuronal tumor with histone H3 K27M mutation","volume":"4","author":"Orillac","year":"2016","journal-title":"Acta Neuropathol Commun"},{"key":"key\n\t\t\t\t20180315101246_nly006-B10","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1111\/bpa.12336","article-title":"Diffuse midline gliomas with histone H3-K27M mutation: A series of 47 cases assessing the spectrum of morphologic variation and associated genetic alterations","volume":"26","author":"Solomon","year":"2016","journal-title":"Brain Pathol"},{"key":"key\n\t\t\t\t20180315101246_nly006-B11","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s10014-017-0288-6","article-title":"Histone H3 K27M mutations in adult cerebellar high-grade gliomas","volume":"34","author":"Nakata","year":"2017","journal-title":"Brain Tumor Pathol"},{"key":"key\n\t\t\t\t20180315101246_nly006-B12","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s11060-013-1312-2","article-title":"Molecular analysis of diffuse intrinsic brainstem gliomas in adults","volume":"116","author":"Reyes-Botero","year":"2014","journal-title":"J Neurooncol"},{"key":"key\n\t\t\t\t20180315101246_nly006-B13","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/nan.12246","article-title":"Diagnostic, prognostic and predictive relevance of molecular markers in gliomas","volume":"41","author":"Brandner","year":"2015","journal-title":"Neuropathol Appl Neurobiol"},{"key":"key\n\t\t\t\t20180315101246_nly006-B14","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization Classification of Tumors of the Central Nervous System: A summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180315101246_nly006-B15","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00401-016-1611-8","article-title":"Prognostic impact of the 2016 WHO classification of diffuse gliomas in the French POLA cohort","volume":"132","author":"Tabouret","year":"2016","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180315101246_nly006-B16","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.ccr.2013.10.006","article-title":"Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas","volume":"24","author":"Bender","year":"2013","journal-title":"Cancer Cell"},{"key":"key\n\t\t\t\t20180315101246_nly006-B17","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1101\/gad.217778.113","article-title":"The histone H3.3K27M mutation in pediatric glioma reprograms H3K27 methylation and gene expression","volume":"27","author":"Chan","year":"2013","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20180315101246_nly006-B18","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1126\/science.1232245","article-title":"Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma","volume":"340","author":"Lewis","year":"2013","journal-title":"Science"},{"key":"key\n\t\t\t\t20180315101246_nly006-B19","doi-asserted-by":"crossref","first-page":"2546","DOI":"10.4161\/cc.25625","article-title":"A lesson learned from the H3.3K27M mutation found in pediatric glioma: A new approach to the study of the function of histone modifications in vivo?","volume":"12","author":"Chan","year":"2013","journal-title":"Cell Cycle"},{"key":"key\n\t\t\t\t20180315101246_nly006-B20","doi-asserted-by":"crossref","first-page":"e1501354","DOI":"10.1126\/sciadv.1501354","article-title":"Mutations in chromatin machinery and pediatric high-grade glioma","volume":"2","author":"Lulla","year":"2016","journal-title":"Sci Adv"},{"key":"key\n\t\t\t\t20180315101246_nly006-B21","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/nature10833","article-title":"Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma","volume":"482","author":"Schwartzentruber","year":"2012","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180315101246_nly006-B22","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1038\/cr.2011.14","article-title":"The double face of the histone variant H3.3","volume":"21","author":"Szenker","year":"2011","journal-title":"Cell Res"},{"key":"key\n\t\t\t\t20180315101246_nly006-B23","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1093\/brain\/124.12.2528","article-title":"Brainstem gliomas in adults: Prognostic factors and classification","volume":"124","author":"Guillamo","year":"2001","journal-title":"Brain"},{"key":"key\n\t\t\t\t20180315101246_nly006-B24","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1212\/WNL.51.4.1136","article-title":"Adult brainstem gliomas","volume":"51","author":"Landolfi","year":"1998","journal-title":"Neurology"},{"key":"key\n\t\t\t\t20180315101246_nly006-B25","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1111\/bpa.12455","article-title":"H3 K27M mutation in gangliogliomas can be associated with poor prognosis","volume":"27","author":"Kleinschmidt-DeMasters","year":"2017","journal-title":"Brain Pathol"},{"key":"key\n\t\t\t\t20180315101246_nly006-B26","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1093\/neuonc\/now274","article-title":"Characteristics of H3 K27M-mutant gliomas in adults","volume":"19","author":"Meyronet","year":"2017","journal-title":"Neuro Oncol"},{"key":"key\n\t\t\t\t20180315101246_nly006-B27","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/acn3.184","article-title":"Long survival in a child with a mutated K27M-H3.3 pilocytic astrocytoma","volume":"2","author":"Hochart","year":"2015","journal-title":"Ann Clin Transl Neurol"},{"key":"key\n\t\t\t\t20180315101246_nly006-B28","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/2017.4.JNS162443","article-title":"Brainstem pilocytic astrocytoma with H3 K27M mutation: Case report","author":"Morita","year":"2017","journal-title":"J Neurosurg"},{"key":"key\n\t\t\t\t20180315101246_nly006-B29","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1038\/nm0715-827a","article-title":"Functionally defined therapeutic targets in diffuse intrinsic pontine glioma","volume":"21","author":"Grasso","year":"2015","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20180315101246_nly006-B30","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/nm.3716","article-title":"Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma","volume":"20","author":"Hashizume","year":"2014","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20180315101246_nly006-B31","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1111\/j.1365-2559.2006.02458.x","article-title":"Counting cells made easier","volume":"49","author":"Going","year":"2006","journal-title":"Histopathology"},{"key":"key\n\t\t\t\t20180315101246_nly006-B32","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1159\/000028893","article-title":"Tectal gliomas: Natural history of an indolent lesion in pediatric patients","volume":"32","author":"Bowers","year":"2000","journal-title":"Pediatr Neurosurg"},{"key":"key\n\t\t\t\t20180315101246_nly006-B33","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1097\/00019052-200112000-00006","article-title":"Brain stem gliomas","volume":"14","author":"Guillamo","year":"2001","journal-title":"Curr Opin Neurol"},{"key":"key\n\t\t\t\t20180315101246_nly006-B34","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s00401-014-1337-4","article-title":"Specific detection of methionine 27 mutation in histone 3 variants (H3K27M) in fixed tissue from high-grade astrocytomas","volume":"128","author":"Bechet","year":"2014","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180315101246_nly006-B35","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/s00401-014-1338-3","article-title":"A sensitive and specific histopathologic prognostic marker for H3F3A K27M mutant pediatric glioblastomas","volume":"128","author":"Venneti","year":"2014","journal-title":"Acta Neuropathol"},{"key":"key\n\t\t\t\t20180315101246_nly006-B36","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1126\/science.1253799","article-title":"Use of human embryonic stem cells to model pediatric gliomas with H3.3K27M histone mutation","volume":"346","author":"Funato","year":"2014","journal-title":"Science"},{"key":"key\n\t\t\t\t20180315101246_nly006-B37","doi-asserted-by":"crossref","first-page":"795","DOI":"10.3174\/ajnr.A5076","article-title":"Imaging characteristics of pediatric diffuse midline gliomas with histone H3 K27M mutation","volume":"38","author":"Aboian","year":"2017","journal-title":"Am J Neuroradiol"}],"container-title":["Journal of Neuropathology &amp; Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jnen\/article-pdf\/77\/4\/302\/24372533\/nly006.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,15]],"date-time":"2018-03-15T10:13:06Z","timestamp":1521108786000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article\/77\/4\/302\/4851722"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,10]]},"references-count":37,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,2,10]]},"published-print":{"date-parts":[[2018,4,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jnen\/nly006","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"value":"0022-3069","type":"print"},{"value":"1554-6578","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,4]]},"published":{"date-parts":[[2018,2,10]]}}}