{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T21:42:43Z","timestamp":1789940563020,"version":"4.0.1"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Key Research and Development Project of Shandong Province","award":["2018GSF118226"],"award-info":[{"award-number":["2018GSF118226"]}]},{"name":"Shandong Medical and Health Science Technology Development Program","award":["2017WS094"],"award-info":[{"award-number":["2017WS094"]}]},{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81402479"],"award-info":[{"award-number":["81402479"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Solitary fibrous tumor\/hemangiopericytomas (SFT\/HPCs) are mesenchymal tumors characterized by \u201cstaghorn\u201d blood vessels and collagen deposition. Little is known about SFT\/HPCs with papillary architecture. We summarized the clinicopathologic features of 12 patients with papillary SFT\/HPCs (8 males and 4 females; median age: 59\u2009years), including 8 previously reported cases. Tumors were present in the meninges (75%, 9\/12), adrenal gland (8%, 1\/12), orbit (8%, 1\/12), or spinal canal (8%, 1\/12). Six tumors (50%) had a true papillary architecture with fibrovascular cores and 6 tumors (50%) had a pseudopapillary architecture with vascular cores. Nuclear staining for STAT6 was present in all tested tumors (10\/10). RT-PCR indicated NAB2 ex6-STAT6 ex17 fusion in 4 tumors (80%, 4\/5) and NAB2 ex4-STAT6 ex2 fusion in 1 tumor (20%, 1\/5). Five patients (42%, 5\/12), all with tumors in the meninges, developed local recurrence at a median of 61\u2009months after surgery (range: 56\u2013165\u2009months; mean: 88.6\u2009months). These results indicated that the papillary architecture is a morphological form of SFT\/HPCs. The recognition of this pattern, with appropriate immunohistochemical analysis and assessment of NAB2-STAT6 fusion, should facilitate the distinction of these rare neoplasms from morphologically similar tumors in the meninges, lung, pleura, and soft tissue.<\/jats:p>","DOI":"10.1093\/jnen\/nlz053","type":"journal-article","created":{"date-parts":[[2019,7,19]],"date-time":"2019-07-19T17:11:21Z","timestamp":1563556281000},"page":"685-693","source":"Crossref","is-referenced-by-count":14,"title":["Papillary Solitary Fibrous Tumor\/Hemangiopericytoma: An Uncommon Morphological Form With NAB2-STAT6 Gene Fusion"],"prefix":"10.1093","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8034-6524","authenticated-orcid":false,"given":"Zhi-Gang","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China"},{"name":"Shandong Provincial Hospital Affiliated to Shandong First Medical University, Tai\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Bo","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital of University of Science and Technology of China (USTC), Division of Life Sciences and Medicine of USTC, Hefei, Anhui, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Hua","family":"Hao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Taihe Hospital, Hubei University of Medicine, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-Fu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang-Zhen","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Second People\u2019s Hospital of Liaocheng, Linqing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China"},{"name":"Shandong Provincial Hospital Affiliated to Shandong First Medical University, Tai\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Feng","family":"Li","sequence":"additional","affiliation":[{"name":"Shandong Provincial Hospital Affiliated to Shandong First Medical University, Tai\u2019an, China"},{"name":"Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Hu","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China"},{"name":"Shandong Provincial Hospital Affiliated to Shandong First Medical University, Tai\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu-Ming","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China"},{"name":"Shandong Provincial Hospital Affiliated to Shandong First Medical University, Tai\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhou","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China"},{"name":"Shandong Provincial Hospital Affiliated to Shandong First Medical University, Tai\u2019an, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dai-Zhong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology, Taihe Hospital, Hubei University of Medicine, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,7,4]]},"reference":[{"key":"2019071913095211800_nlz053-B1","first-page":"1120","volume-title":"Enzinger and Weiss's Soft Tissue Tumors","author":"Weiss","year":"2008","edition":"5th ed."},{"key":"2019071913095211800_nlz053-B2","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1097\/PAP.0b013e318229c004","article-title":"Solitary fibrous tumor of the central nervous system: A 15-year literature survey of 220 cases","volume":"18","author":"Bisceglia","year":"2011","journal-title":"Adv Anat Pathol"},{"key":"2019071913095211800_nlz053-B3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/COC.0000000000000146","article-title":"CNS hemangiopericytoma: A systematic review of 523 patients","volume":"40","author":"Ghose","year":"2017","journal-title":"Am J Clin Oncol"},{"key":"2019071913095211800_nlz053-B4","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1001\/archopht.1966.00970050084016","article-title":"Hemangiopericytoma with cartilaginous differentiation involving orbit","volume":"75","author":"Reeh","year":"1966","journal-title":"Arch Ophthalmol"},{"key":"2019071913095211800_nlz053-B5","first-page":"104","article-title":"Lipomatous hemangiopericytoma of the sellar region: Case report and review of the literature","volume":"44","author":"Esquenazi","year":"2014","journal-title":"Ann Clin Lab Sci"},{"key":"2019071913095211800_nlz053-B6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1365-2559.2005.02290.x","article-title":"Solitary fibrous tumour and haemangiopericytoma: Evolution of a concept","volume":"48","author":"Gengler","year":"2006","journal-title":"Histopathology"},{"key":"2019071913095211800_nlz053-B7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/ng.2522","article-title":"Whole-exome sequencing identifies a recurrent NAB2-STAT6 fusion in solitary fibrous tumors","volume":"45","author":"Chmielecki","year":"2013","journal-title":"Nat Genet"},{"key":"2019071913095211800_nlz053-B8","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1038\/ng.2509","article-title":"Identification of recurrent NAB2-STAT6 gene fusions in solitary fibrous tumor by integrative sequencing","volume":"45","author":"Robinson","year":"2013","journal-title":"Nat Genet"},{"key":"2019071913095211800_nlz053-B9","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s00401-013-1117-6","article-title":"Meningeal hemangiopericytoma and solitary fibrous tumors carry the NAB2-STAT6 fusion and can be diagnosed by nuclear expression of STAT6 protein","volume":"125","author":"Schweizer","year":"2013","journal-title":"Acta Neuropathol"},{"key":"2019071913095211800_nlz053-B10","first-page":"80","volume-title":"World Health Organization Classification of Tumours of Soft Tissue and Bone","author":"Fletcher","year":"2013","edition":"4th ed"},{"key":"2019071913095211800_nlz053-B11","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 world health organization classification of tumors of the central nervous system: A summary","volume":"131","author":"Louis","year":"2016","journal-title":"Acta Neuropathol"},{"key":"2019071913095211800_nlz053-B12","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1053\/j.semdp.2006.11.006","article-title":"Special stains in diagnostic liver pathology","volume":"23","author":"Lefkowitch","year":"2006","journal-title":"Semin Diagn Pathol"},{"key":"2019071913095211800_nlz053-B13","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/S0046-8177(87)80243-5","article-title":"The formaldehyde-fixed and paraffin-embedded tissues for diagnostic transmission electron microscopy: A retrospective and prospective study","volume":"18","author":"Wang","year":"1987","journal-title":"Hum Pathol"},{"key":"2019071913095211800_nlz053-B14","first-page":"181","article-title":"Intracranial solitary fibrous tumor with pseudopapillary architecture: An uncommon tumor with unusual histopathology","volume":"9","author":"Yang","year":"2016","journal-title":"North Am J Med Sci"},{"key":"2019071913095211800_nlz053-B15","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10014-015-0247-z","article-title":"\u2018Papillary' solitary fibrous tumor\/hemangiopericytoma with nuclear STAT6 expression and NAB2-STAT6 fusion","volume":"33","author":"Ishizawa","year":"2016","journal-title":"Brain Tumor Pathol"},{"key":"2019071913095211800_nlz053-B16","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1097\/PAS.0000000000000625","article-title":"Analysis of NAB2-STAT6 gene fusion in 17 cases of meningeal solitary fibrous tumor\/hemangiopericytoma: Review of the literature","volume":"40","author":"Yuzawa","year":"2016","journal-title":". Am J Surg Pathol"},{"key":"2019071913095211800_nlz053-B17","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/j.prp.2014.03.001","article-title":"STAT6-positive intraorbital papillary tumor: A rare variant of solitary fibrous tumor?","volume":"210","author":"Tsukamoto","year":"2014","journal-title":"Pathol Res Pract"},{"key":"2019071913095211800_nlz053-B18","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.anndiagpath.2013.01.002","article-title":"Spinal extradural solitary fibrous tumor with retiform and papillary features","volume":"17","author":"Tomek","year":"2013","journal-title":"Ann Diagn Pathol"},{"key":"2019071913095211800_nlz053-B19","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/00005072-198301000-00005","article-title":"Meningioma with microcystic pattern. A case report","volume":"42","author":"Kepes","year":"1983","journal-title":"J Neuropathol Exp Neurol"},{"key":"2019071913095211800_nlz053-B20","doi-asserted-by":"crossref","first-page":"432","DOI":"10.5858\/2003-127-0432-SFTITC","article-title":"Solitary fibrous tumors in the central nervous system. A clinicopathologic review of 18 cases and comparison to meningeal hemangiopericytomas","volume":"127","author":"Tihan","year":"2003","journal-title":"Arch Pathol Lab Med"},{"key":"2019071913095211800_nlz053-B21","first-page":"178","article-title":"Meningeal solitary fibrous tumor: Report of a case and literature review","volume":"43","author":"Deniz","year":"2005","journal-title":"Folia Neuropathol"},{"key":"2019071913095211800_nlz053-B22","first-page":"13166","article-title":"Immunohistochemical detection of STAT6, CD34, CD99 and BCL-2 for diagnosing solitary fibrous tumors\/hemangiopericytomas","volume":"8","author":"Han","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"2019071913095211800_nlz053-B23","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1097\/00000478-200107000-00008","article-title":"Solitary fibrous tumor of the oral soft tissues: A clinicopathologic and immunohistochemicalstudy of 16 cases","volume":"25","author":"Alawi","year":"2001","journal-title":"Am J Surg Pathol"},{"key":"2019071913095211800_nlz053-B24","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1750-3639.2011.00552.x","article-title":"Solitary fibrous tumors and hemangiopericytomas of the meninges: Overlapping pathological features and common prognostic factors suggest the same spectrum of tumors","volume":"22","author":"Bouvier","year":"2012","journal-title":"Brain Pathol"},{"key":"2019071913095211800_nlz053-B25","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00401-015-1459-3","article-title":"Somatostatin receptor 2a is a more sensitive diagnostic marker of meningioma than epithelial membrane antigen","volume":"130","author":"Menke","year":"2015","journal-title":"Acta Neuropathol"},{"key":"2019071913095211800_nlz053-B26","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/modpathol.2015.70","article-title":"Solitary fibrous tumors: Loss of chimeric protein expression and genomic instability mark dedifferentiation","volume":"28","author":"Dagrada","year":"2015","journal-title":"Mod Pathol"},{"key":"2019071913095211800_nlz053-B27","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/jnen\/nlv026","article-title":"NAB2-STAT6 gene fusion in meningeal hemangiopericytoma and solitary fibrous tumor","volume":"75","author":"Fritchie","year":"2016","journal-title":"J Neuropathol Exp Neurol"},{"key":"2019071913095211800_nlz053-B28","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.mce.2015.10.011","article-title":"Identification of a novel fusion transcript between human relaxin-1 (RLN1) and human relaxin-2 (RLN2) in prostate cancer","volume":"420","author":"Tevz","year":"2016","journal-title":"Mol Cell Endocrinol"},{"key":"2019071913095211800_nlz053-B29","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1097\/PAS.0000000000000137","article-title":"STAT6 immunohistochemistry is helpful in the diagnosis of solitary fibrous tumors","volume":"38","author":"Yoshida","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"2019071913095211800_nlz053-B30","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.wneu.2013.11.009","article-title":"Intracranial hemangiopericytoma \u2013 our experience in 30 years: A series of 43 cases and review of the literature","volume":"81","author":"Melone","year":"2014","journal-title":"World Neurosurg"},{"key":"2019071913095211800_nlz053-B31","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1016\/S0046-8177(99)90169-7","article-title":"Extrathoracic solitary fibrous tumors: Their histological variability and potentially aggressive behavior","volume":"30","author":"Hasegawa","year":"1999","journal-title":"Hum Pathol"}],"container-title":["Journal of Neuropathology &amp; Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jnen\/article-pdf\/78\/8\/685\/28964741\/nlz053.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T08:02:58Z","timestamp":1664006578000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article\/78\/8\/685\/5528280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,4]]},"references-count":31,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2019,7,4]]},"published-print":{"date-parts":[[2019,8,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jnen\/nlz053","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"value":"0022-3069","type":"print"},{"value":"1554-6578","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,8]]},"published":{"date-parts":[[2019,7,4]]}}}