{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:55:01Z","timestamp":1793451301144,"version":"4.5.0"},"reference-count":108,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T00:00:00Z","timestamp":1565308800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Institute of Child Health and Development","award":["R37-HD20991"],"award-info":[{"award-number":["R37-HD20991"]}]},{"name":"National Institute of Child Health and Development","award":["PO1-HD036379"],"award-info":[{"award-number":["PO1-HD036379"]}]},{"name":"National Institute of Child Health and Development","award":["P30-HD18655"],"award-info":[{"award-number":["P30-HD18655"]}]},{"DOI":"10.13039\/100001524","name":"CJ Foundation for SIDS","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001524","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010320","name":"Cooper Trewin Brighter Days Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010320","id-type":"DOI","asserted-by":"publisher"}]},{"name":"River\u2019s Gift"},{"name":"Evelyn Deborah Barrett Fellowship for SIDS Research"},{"name":"Marley J. Cherella Fellowship for SIDS Research"},{"name":"First Candle\/SIDS Alliance"},{"name":"CJ Murphy Foundation for Solving the Puzzle of SIDS"},{"name":"Barrett Tallman Memorial Fund"},{"name":"Florida SIDS Alliance"},{"name":"Jacob Neil Boger Foundation for SIDS"},{"name":"Jason Lutz SIDS Foundation"},{"name":"Three Butterflies Foundation"},{"name":"Bennett C. Endres Fellowship"},{"name":"The Family of Lyla Heffernan"},{"name":"Robert\u2019s Program on Sudden Unexpected Death in Pediatrics"},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The sudden infant death syndrome (SIDS) is the leading cause of postneonatal infant mortality in the United States today, with an overall rate of 0.39\/1000 live births. It is defined as the sudden and unexpected death of an infant &amp;lt;12\u2009months of age that remains unexplained after a complete autopsy, death scene investigation, and review of the clinical history. The serotonin brainstem hypothesis has been a leading hypothesis for SIDS over the last 2 decades. Our laboratory has studied this hypothesis over time with a variety of tissue techniques, including tissue receptor autoradiography, high performance liquid chromatography, Western blot analysis, immunocytochemistry, and proteomics. The purpose of this article is to review the progress in our laboratory toward supporting this hypothesis. We conclude that an important subset of SIDS infants has serotonergic abnormalities resulting from a \u201ccore lesion\u201d in the medullary reticular formation comprised of nuclei that contain serotonin neurons. This lesion could lead to a failure of protective brainstem responses to homeostatic challenges during sleep in a critical developmental period which cause sleep-related sudden death.<\/jats:p>","DOI":"10.1093\/jnen\/nlz062","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T00:07:38Z","timestamp":1566432458000},"page":"765-779","source":"Crossref","is-referenced-by-count":68,"title":["The Serotonin Brainstem Hypothesis for the Sudden Infant Death Syndrome"],"prefix":"10.1093","volume":"78","author":[{"given":"Hannah C","family":"Kinney","sequence":"first","affiliation":[{"name":"Department of Pathology, Boston Children\u2019s Hospital and Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin L","family":"Haynes","sequence":"additional","affiliation":[{"name":"Department of Pathology, Boston Children\u2019s Hospital and Harvard Medical School, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,8,9]]},"reference":[{"key":"2019122722073742500_nlz062-B1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.3109\/15513819109065465","article-title":"Defining the sudden infant death syndrome (SIDS): Deliberations of an expert panel convened by the National Institute of Child Health and Human Development","volume":"11","author":"Willinger","year":"1991","journal-title":"Pediatr Pathol"},{"key":"2019122722073742500_nlz062-B2","year":"2018"},{"key":"2019122722073742500_nlz062-B3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1542\/peds.2015-2298","article-title":"Overall postneonatal mortality and rates of SIDS","volume":"137","author":"Goldstein","year":"2016","journal-title":"Pediatrics"},{"key":"2019122722073742500_nlz062-B4","first-page":"1038","volume-title":"Principals of Neural Science.","author":"Richerson","year":"2012","edition":"5th 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