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We have previously demonstrated that brains of IIH patients exhibit patchy astrogliosis, increased perivascular expression of the water channel aquaporin-4 (AQP4) as well as degenerating pericyte processes and capillary basement membranes. Given the established association between pericyte degeneration and blood-brain barrier (BBB) dysfunction, we investigated blood protein leakage by light microscopic immunohistochemistry. We also assessed perivascular AQP4 expression by immunogold transmission electron microscopy. The study included 14 IIH patients and 14 reference (REF) subjects undergoing neurosurgery for epilepsy, aneurysm, or tumor. Evidence of BBB dysfunction, measured as area extravasated fibrinogen\/fibrin, was significantly more pronounced in IIH than REF individuals. The extent of extravasated fibrinogen was positively correlated with increasing degree of astrogliosis and vascular AQP4 immunoreactivity, determined by light microscopy. Immunogold transmission electron microscopy revealed no overall changes in AQP4 expression at astrocytic vascular endfeet in IIH (n\u2009=\u20098) compared to REF (n\u2009=\u200911) individuals. Our results provide evidence of BBB leakage in IIH, signifying that IIH is a more serious neurodegenerative disease than previously considered.<\/jats:p>","DOI":"10.1093\/jnen\/nlz063","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T11:05:16Z","timestamp":1565262316000},"page":"808-818","source":"Crossref","is-referenced-by-count":44,"title":["Blood-Brain Barrier Dysfunction in Idiopathic Intracranial Hypertension"],"prefix":"10.1093","volume":"78","author":[{"given":"Md Mahdi","family":"Hasan-Olive","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Oslo University Hospital - Rikshospitalet"},{"name":"Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Arne","family":"Hansson","sequence":"additional","affiliation":[{"name":"Institute of Biomedicine, University of Gothenburg, G\u00f6teborg, 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