{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T04:42:02Z","timestamp":1769575322164,"version":"3.49.0"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T00:00:00Z","timestamp":1566604800000},"content-version":"vor","delay-in-days":30,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100008732","name":"The Uehara Memorial Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"name":"KAKENHI","award":["JP15k08867"],"award-info":[{"award-number":["JP15k08867"]}]},{"name":"KAKENHI","award":["JP17k09263"],"award-info":[{"award-number":["JP17k09263"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Here, we report a 74-year-old woman with a long history of schizophrenia but no clinical manifestation of dementia. Cause of death after autopsy was atherosclerotic heart disease. Although neuropathological investigation showed no significant brain atrophy, superficial microvacuolation with neuronal loss was restrictedly detected in the right anterior cingulate gyrus by microscopic examination. Pick bodies (PBs) positive for Bodian and Bielshowsky staining and 3-repeat-tau were detected in frontal and temporal lobes and limbic regions. Prevalence of PBs was most frequent in the right anterior cingulate gyrus and lateral base, followed by other neocortical regions of the frontal lobe, amygdala, and granular layer of the hippocampus. Although the number of glial inclusions was low, ramified astrocytes and various forms of astrocytes with AT8-positive inclusions were also found. Thus, the case may reflect preclinical or very early clinical Pick disease. Distribution of PBs does not necessarily have to be consistent with previously reported preclinical\/early clinical Pick disease. These results show that tau pathology in the earlier stage of Pick disease may be heterogeneous, and the anterior cingulate gyrus may be initially affected in Pick disease. Neuropathological examination, including immunohistochemistry without case selection, is useful in identifying clinical and pathological manifestations of Pick disease.<\/jats:p>","DOI":"10.1093\/jnen\/nlz077","type":"journal-article","created":{"date-parts":[[2019,8,24]],"date-time":"2019-08-24T03:14:29Z","timestamp":1566616469000},"page":"971-974","source":"Crossref","is-referenced-by-count":4,"title":["An Autopsy Case of Preclinical\/Early Clinical Pick Disease"],"prefix":"10.1093","volume":"78","author":[{"given":"Keitaro","family":"Okada","sequence":"first","affiliation":[{"name":"University of Toyama, Fuculty of Medicine"},{"name":"Department of Legal Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukiko","family":"Hata","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoichiro","family":"Takayanagi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Takayanagi","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Arisawabashi Hospital, Toyama, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6921-1768","authenticated-orcid":false,"given":"Naoki","family":"Nishida","sequence":"additional","affiliation":[{"name":"Department of Legal Medicine, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,7,25]]},"reference":[{"key":"2019091819512355100_nlz077-B1","first-page":"165","article-title":"Ueber die Beziehungen der seneten Hirnatrophie zur Aphasie","volume":"17","author":"Pick","year":"1892","journal-title":"Prog Med Wochensher"},{"key":"2019091819512355100_nlz077-B2","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1111\/neup.12104","article-title":"An autopsy case of incipient Pick\u2019s disease: Immunohistochemical profiles of early-stage Pick body formation","volume":"34","author":"Miki","year":"2014","journal-title":"Neuropathology"},{"key":"2019091819512355100_nlz077-B3","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s00401-005-0988-6","article-title":"Silver staining profiles distinguish Pick bodies from neurofibrillary tangles of Alzheimer type: Comparison between Gallyas and Campbell-Switzer methods","volume":"109","author":"Uchihara","year":"2005","journal-title":"Acta Neuropathol"},{"key":"2019091819512355100_nlz077-B4","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1002\/ana.10222","article-title":"Sporadic Pick disease: A tauopathy characterized by a spectrum of pathological tau isoforms in gray and white matter","volume":"51","author":"Zhukareva","year":"2002","journal-title":"Ann Neurol"},{"key":"2019091819512355100_nlz077-B5","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1007\/BF00688501","article-title":"Early Pick disease. 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