{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:08:05Z","timestamp":1769558885572,"version":"3.49.0"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2019,10,29]],"date-time":"2019-10-29T00:00:00Z","timestamp":1572307200000},"content-version":"vor","delay-in-days":36,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2019,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Astrocytes are increasingly recognized as active contributors to the disease process in multiple sclerosis (MS), rather than being merely reactive. We investigated the expression of a selected microRNA (miRNA) panel that could contribute both to the injury and to the recovery phases of the disease. Individual astrocytes were laser microdissected from brain sections. We then compared the miRNAs\u2019 expressions in MS and control brain samples at different lesional stages in white versus grey matter regions. In active MS lesions, we found upregulation of ischemia-related miRNAs in white but not grey matter, often with reversion to the normal state in inactive lesions. In contrast to our previous findings on MS macrophages, expression of 2 classical inflammatory-related miRNAs, miRNA-155 and miRNA-146a, was reduced in astrocytes from active and chronic active MS lesions in white and grey matter, suggesting a lesser direct pathogenetic role for these miRNAs in astrocytes. miRNAs within the categories regulating aquaporin4 (-100, -145, -320) and glutamate transport\/apoptosis\/neuroprotection (-124a, -181a, and -29a) showed some contrasting responses. The regional and lesion-stage differences of expression of these miRNAs indicate the remarkable ability of astrocytes to show a wide range of selective responses in the face of differing insults and phases of resolution.<\/jats:p>","DOI":"10.1093\/jnen\/nlz098","type":"journal-article","created":{"date-parts":[[2019,10,30]],"date-time":"2019-10-30T18:01:56Z","timestamp":1572458516000},"page":"1130-1146","source":"Crossref","is-referenced-by-count":20,"title":["Astrocytes in the Pathogenesis of Multiple Sclerosis: An In Situ MicroRNA Study"],"prefix":"10.1093","volume":"78","author":[{"given":"Vijayaraghava T S","family":"Rao","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Chieh","family":"Fuh","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason R","family":"Karamchandani","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Montreal Neurological Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M J","family":"Woulfe","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Ottawa Hospital, University of Ottawa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David G","family":"Munoz","sequence":"additional","affiliation":[{"name":"Department of Pathology, St. Michaels Hospital, Toronto University, Toronto"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Ellezam","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Montreal, Montreal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manon","family":"Blain","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine, Queen\u2019s University, Kingston, ON, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Kai","family":"Ho","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry J","family":"Bedell","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack P","family":"Antel","sequence":"additional","affiliation":[{"name":"Department of Neuropathology, Montreal Neurological Institute"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel K","family":"Ludwin","sequence":"additional","affiliation":[{"name":"Department of Pathology, The Ottawa Hospital, University of Ottawa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,9,23]]},"reference":[{"key":"2019112009002834900_nlz098-B1","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/B978-0-12-802395-2.00019-5","article-title":"Inflammatory demyelinating diseases of the central nervous system","volume":"145","author":"Hoftberger","year":"2017","journal-title":"Handb Clin Neurol"},{"key":"2019112009002834900_nlz098-B2","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1474-4422(14)70267-4","article-title":"Environmental risk factors and multiple sclerosis: An umbrella review of systematic reviews and meta-analyses","volume":"14","author":"Belbasis","year":"2015","journal-title":"Lancet Neurol"},{"key":"2019112009002834900_nlz098-B3","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1097\/WCO.0000000000000325","article-title":"Repair strategies for multiple sclerosis: Challenges, achievements and perspectives","volume":"29","author":"Stankoff","year":"2016","journal-title":"Curr Opin Neurol"},{"key":"2019112009002834900_nlz098-B4","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.tins.2009.08.002","article-title":"Molecular dissection of reactive astrogliosis and glial scar formation","volume":"32","author":"Sofroniew","year":"2009","journal-title":"Trends Neurosci"},{"key":"2019112009002834900_nlz098-B5","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.neuroscience.2013.10.050","article-title":"White matter astrocytes in health and disease","volume":"276","author":"Lundgaard","year":"2014","journal-title":"Neuroscience"},{"key":"2019112009002834900_nlz098-B6","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1007\/s11481-013-9480-6","article-title":"Immune players in the CNS: The astrocyte","volume":"8","author":"Jensen","year":"2013","journal-title":"J Neuroimmune Pharmacol"},{"key":"2019112009002834900_nlz098-B7","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1002\/glia.20546","article-title":"Astrocytes \u2013 friends or foes in multiple sclerosis?","volume":"55","author":"Williams","year":"2007","journal-title":"Glia"},{"key":"2019112009002834900_nlz098-B8","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1177\/1352458516643396","article-title":"Astrocytes in multiple sclerosis","volume":"22","author":"Ludwin","year":"2016","journal-title":"Mult Scler"},{"key":"2019112009002834900_nlz098-B9","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/glia.22443","article-title":"The astrocyte in multiple sclerosis revisited","volume":"61","author":"Brosnan","year":"2013","journal-title":"Glia"},{"key":"2019112009002834900_nlz098-B10","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00281-015-0515-3","article-title":"Control of autoimmune CNS inflammation by astrocytes","volume":"37","author":"Rothhammer","year":"2015","journal-title":"Semin Immunopathol"},{"key":"2019112009002834900_nlz098-B11","doi-asserted-by":"crossref","first-page":"2106","DOI":"10.1016\/S0140-6736(04)17551-X","article-title":"A serum autoantibody marker of neuromyelitis optica: Distinction from multiple sclerosis","volume":"364","author":"Lennon","year":"2004","journal-title":"Lancet"},{"key":"2019112009002834900_nlz098-B12","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1093\/jnen\/nlv016","article-title":"MicroRNA expression patterns in human astrocytes in relation to anatomical location and age","volume":"75","author":"Rao","year":"2016","journal-title":"J Neuropathol Exp Neurol"},{"key":"2019112009002834900_nlz098-B13","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1002\/glia.23576","article-title":"miR-223 promotes regenerative myeloid cell phenotype and function in the demyelinated central nervous system","volume":"67","author":"Galloway","year":"2019","journal-title":"Glia"},{"key":"2019112009002834900_nlz098-B14","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00401-016-1653-y","article-title":"An updated histological classification system for multiple sclerosis lesions","volume":"133","author":"Kuhlmann","year":"2017","journal-title":"Acta Neuropathol"},{"key":"2019112009002834900_nlz098-B15","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1002\/ana.23967","article-title":"MiR-155 as a multiple sclerosis-relevant regulator of myeloid cell polarization","volume":"74","author":"Moore","year":"2013","journal-title":"Ann Neurol"},{"key":"2019112009002834900_nlz098-B16","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12885-016-3008-4","article-title":"Differential long-term stability of microRNAs and RNU6B snRNA in 12-20-year-old archived formalin-fixed paraffin-embedded specimens","volume":"17","author":"Peskoe","year":"2017","journal-title":"BMC Cancer"},{"key":"2019112009002834900_nlz098-B17","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18030627","article-title":"Evaluation and adaptation of a laboratory-based cDNA library preparation protocol for retrospective sequencing of archived MicroRNAs from up to 35-year-old clinical FFPE specimens","volume":"18","author":"Loudig","year":"2017","journal-title":"Int J Mol Sci"},{"key":"2019112009002834900_nlz098-B18","doi-asserted-by":"crossref","first-page":"e0163125","DOI":"10.1371\/journal.pone.0163125","article-title":"MicroRNA stability in FFPE tissue samples: Dependence on GC content","volume":"11","author":"Kakimoto","year":"2016","journal-title":"PLoS One"},{"key":"2019112009002834900_nlz098-B19","doi-asserted-by":"crossref","first-page":"a029009","DOI":"10.1101\/cshperspect.a029009","article-title":"Regulation of astrocyte functions in multiple sclerosis","volume":"9","author":"Wheeler","year":"2019","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2019112009002834900_nlz098-B20","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1161\/STROKEAHA.107.500736","article-title":"MicroRNA expression in the blood and brain of rats subjected to transient focal ischemia by middle cerebral artery occlusion","volume":"39","author":"Jeyaseelan","year":"2008","journal-title":"Stroke"},{"key":"2019112009002834900_nlz098-B21","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jneuroim.2016.04.014","article-title":"MicroRNAs associated with the pathogenesis of multiple sclerosis","volume":"295\u2013296","author":"Huang","year":"2016","journal-title":"J Neuroimmunol"},{"key":"2019112009002834900_nlz098-B22","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1093\/brain\/awv398","article-title":"The topograpy of demyelination and neurodegeneration in the multiple sclerosis brain","volume":"139","author":"Haider","year":"2016","journal-title":"Brain"},{"key":"2019112009002834900_nlz098-B23","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0022-510X(02)00421-5","article-title":"Hypoxia-like tissue injury as a component of multiple sclerosis lesions","volume":"206","author":"Lassmann","year":"2003","journal-title":"J Neurol Sci"},{"key":"2019112009002834900_nlz098-B24","doi-asserted-by":"crossref","first-page":"16477","DOI":"10.1038\/srep16477","article-title":"Reduced cortical microvascular oxygenation in multiple sclerosis: A blinded, case-controlled study using a novel quantitative near-infrared spectroscopy method","volume":"5","author":"Yang","year":"2015","journal-title":"Sci Rep"},{"key":"2019112009002834900_nlz098-B25","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1002\/ana.23880","article-title":"Circulating microRNAs as biomarkers for disease staging in multiple sclerosis","volume":"73","author":"Gandhi","year":"2013","journal-title":"Ann Neurol"},{"key":"2019112009002834900_nlz098-B26","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1093\/brain\/awp300","article-title":"MicroRNA profiling of multiple sclerosis lesions identifies modulators of the regulatory protein CD47","volume":"132","author":"Junker","year":"2009","journal-title":"Brain"},{"key":"2019112009002834900_nlz098-B27","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.biopha.2015.08.025","article-title":"MicroRNA-214 participates in the neuroprotective effect of Resveratrol via inhibiting alpha-synuclein expression in MPTP-induced Parkinson's disease mouse","volume":"74","author":"Wang","year":"2015","journal-title":"Biomed Pharmacother"},{"key":"2019112009002834900_nlz098-B28","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.jns.2017.08.3639","article-title":"Reduction of microRNA-338 protects from ischemic injury in vivo and in vitro, and targets mitochondrial function","volume":"381","author":"Li","year":"2017","journal-title":"J Neurol Sci"},{"key":"2019112009002834900_nlz098-B29","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/01.jnen.0000225024.12074.80","article-title":"The pathogenesis of multiple sclerosis: Relating human pathology to experimental studies","volume":"65","author":"Ludwin","year":"2006","journal-title":"J Neuropathol Exp Neurol"},{"key":"2019112009002834900_nlz098-B30","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1002\/glia.20997","article-title":"Astrocyte hypoxic response is essential for pathological but not developmental angiogenesis of the retina","volume":"58","author":"Weidemann","year":"2010","journal-title":"Glia"},{"key":"2019112009002834900_nlz098-B31","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/glia.23109","article-title":"Hypoxia-independent mechanisms of HIF-1alpha expression in astrocytes after ischemic preconditioning","volume":"65","author":"Hirayama","year":"2017","journal-title":"Glia"},{"key":"2019112009002834900_nlz098-B32","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1002\/glia.21233","article-title":"Interferon regulatory factor 3 inhibits astrocyte inflammatory gene expression through suppression of the proinflammatory miR-155 and miR-155*","volume":"59","author":"Tarassishin","year":"2011","journal-title":"Glia"},{"key":"2019112009002834900_nlz098-B33","doi-asserted-by":"crossref","first-page":"e44789","DOI":"10.1371\/journal.pone.0044789","article-title":"MicroRNA-146a: A key regulator of astrocyte-mediated inflammatory response","volume":"7","author":"Iyer","year":"2012","journal-title":"PLoS One"},{"key":"2019112009002834900_nlz098-B34","doi-asserted-by":"crossref","first-page":"e959","DOI":"10.1038\/cddis.2013.491","article-title":"Dysregulated microRNAs in amyotrophic lateral sclerosis microglia modulate genes linked to neuroinflammation","volume":"4","author":"Parisi","year":"2013","journal-title":"Cell Death Dis"},{"key":"2019112009002834900_nlz098-B35","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.82.10_supplement.P5.018","article-title":"Implicating microRNAs as regulators of microglia and astrocyte responses in human CNS inflammatory disease (P5.018)","volume":"82","author":"Moore","year":"2014","journal-title":"Neurology"},{"key":"2019112009002834900_nlz098-B36","doi-asserted-by":"crossref","first-page":"L727","DOI":"10.1152\/ajplung.00174.2014","article-title":"MicroRNA-146a and microRNA-146b expression and anti-inflammatory function in human airway smooth muscle","volume":"307","author":"Comer","year":"2014","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2019112009002834900_nlz098-B37","first-page":"737","article-title":"Differential regulation of microRNA-146a and microRNA-146b-5p in human retinal pigment epithelial cells by interleukin-1beta, tumor necrosis factor-alpha, and interferon-gamma","volume":"19","author":"Kutty","year":"2013","journal-title":"Mol Vis"},{"key":"2019112009002834900_nlz098-B38","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/j.immuni.2017.06.006","article-title":"Reactive astrocytes: Production, function, and therapeutic potential","volume":"46","author":"Liddelow","year":"2017","journal-title":"Immunity"},{"key":"2019112009002834900_nlz098-B39","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1002\/glia.22657","article-title":"LPS and IL-1 differentially activate mouse and human astrocytes: Role of CD14","volume":"62","author":"Tarassishin","year":"2014","journal-title":"Glia"},{"key":"2019112009002834900_nlz098-B40","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/brain\/awf015","article-title":"BDNF and gp145trkB in multiple sclerosis brain lesions: Neuroprotective interactions between immune and neuronal cells?","volume":"125","author":"Stadelmann","year":"2002","journal-title":"Brain"},{"key":"2019112009002834900_nlz098-B41","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s12974-018-1136-2","article-title":"Human central nervous system astrocytes support survival and activation of B cells: Implications for MS pathogenesis","volume":"15","author":"Touil","year":"2018","journal-title":"J Neuroinflammation"},{"key":"2019112009002834900_nlz098-B42","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/nm.3681","article-title":"Regulation of astrocyte activation by glycolipids drives chronic CNS inflammation","volume":"20","author":"Mayo","year":"2014","journal-title":"Nat Med"},{"key":"2019112009002834900_nlz098-B43","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1038\/s41586-018-0119-x","article-title":"Microglial control of astrocytes in response to microbial metabolites","volume":"557","author":"Rothhammer","year":"2018","journal-title":"Nature"},{"key":"2019112009002834900_nlz098-B44","doi-asserted-by":"crossref","first-page":"29223","DOI":"10.1074\/jbc.M110.144576","article-title":"MicroRNA 320a functions as a novel endogenous modulator of aquaporins 1 and 4 as well as a potential therapeutic target in cerebral ischemia","volume":"285","author":"Sepramaniam","year":"2010","journal-title":"J Biol Chem"},{"key":"2019112009002834900_nlz098-B45","doi-asserted-by":"crossref","first-page":"9530951","DOI":"10.1155\/2017\/9530951","article-title":"Overexpression of microRNA-145 ameliorates astrocyte injury by targeting aquaporin 4 in cerebral ischemic stroke","volume":"2017","author":"Zheng","year":"2017","journal-title":"Biomed Res Int"},{"key":"2019112009002834900_nlz098-B46","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/978-94-024-1057-0_5","article-title":"Aquaporins in nervous system","volume":"969","author":"Xu","year":"2017","journal-title":"Adv Exp Med Biol"},{"key":"2019112009002834900_nlz098-B47","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.neuroscience.2009.08.019","article-title":"Aquaporin-4 in brain and spinal cord oedema","volume":"168","author":"Saadoun","year":"2010","journal-title":"Neuroscience"},{"key":"2019112009002834900_nlz098-B48","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1093\/jnen\/nly121","article-title":"Multiple sclerosis: Destruction and regeneration of astrocytes in acute lesions","volume":"78","author":"Prineas","year":"2019","journal-title":"J Neuropathol Exp Neurol"},{"key":"2019112009002834900_nlz098-B49","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1093\/brain\/awh467","article-title":"Evidence of elevated glutamate in multiple sclerosis using magnetic resonance spectroscopy at 3 T","volume":"128","author":"Srinivasan","year":"2005","journal-title":"Brain"},{"key":"2019112009002834900_nlz098-B50","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.bbi.2015.04.013","article-title":"Metabolic gene expression changes in astrocytes in multiple sclerosis cerebral cortex are indicative of immune-mediated signaling","volume":"48","author":"Zeis","year":"2015","journal-title":"Brain Behav Immun"},{"key":"2019112009002834900_nlz098-B51","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.nbd.2005.06.017","article-title":"Increased expression and function of glutamate transporters in multiple sclerosis","volume":"21","author":"Vallejo-Illarramendi","year":"2006","journal-title":"Neurobiol Dis"},{"key":"2019112009002834900_nlz098-B52","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1038\/jcbfm.2013.157","article-title":"Inhibition of microRNA-181 reduces forebrain ischemia-induced neuronal loss","volume":"33","author":"Moon","year":"2013","journal-title":"J Cereb Blood Flow Metab"},{"key":"2019112009002834900_nlz098-B53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.expneurol.2014.11.007","article-title":"Post-stroke treatment with miR-181 antagomir reduces injury and improves long-term behavioral recovery in mice after focal cerebral ischemia","volume":"264","author":"Xu","year":"2015","journal-title":"Exp Neurol"},{"key":"2019112009002834900_nlz098-B54","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.mcn.2017.05.004","article-title":"Inhibition of miR-181a protects female mice from transient focal cerebral ischemia by targeting astrocyte estrogen receptor-alpha","volume":"82","author":"Stary","year":"2017","journal-title":"Mol Cell Neurosci"},{"key":"2019112009002834900_nlz098-B55","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1002\/glia.22556","article-title":"Astrocyte-enriched miR-29a targets PUMA and reduces neuronal vulnerability to forebrain ischemia","volume":"61","author":"Ouyang","year":"2013","journal-title":"Glia"},{"key":"2019112009002834900_nlz098-B56","first-page":"1707","article-title":"MiR29a ameliorates ischemic injury of astrocytes in vitro by targeting the water channel protein aquaporin 4","volume":"41","author":"Zheng","year":"2019","journal-title":"Oncol Rep"},{"key":"2019112009002834900_nlz098-B57","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/s41419-018-0343-1","article-title":"MiR-129-5p targets Wnt5a to block PKC\/ERK\/NF-kappaB and JNK pathways in glioblastoma","volume":"9","author":"Zeng","year":"2018","journal-title":"Cell Death Dis"},{"key":"2019112009002834900_nlz098-B58","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1523\/JNEUROSCI.0600-12.2013","article-title":"Comprehensive expression analyses of neural cell-type-specific miRNAs identify new determinants of the specification and maintenance of neuronal phenotypes","volume":"33","author":"Jovicic","year":"2013","journal-title":"J Neurosci"},{"key":"2019112009002834900_nlz098-B59","doi-asserted-by":"crossref","first-page":"e55652","DOI":"10.1371\/journal.pone.0055652","article-title":"Photofrin based photodynamic therapy and miR-99a transfection inhibited FGFR3 and PI3K\/Akt signaling mechanisms to control growth of human glioblastoma In vitro and in vivo","volume":"8","author":"Chakrabarti","year":"2013","journal-title":"PLoS One"},{"key":"2019112009002834900_nlz098-B60","doi-asserted-by":"crossref","first-page":"5416","DOI":"10.18632\/oncotarget.2116","article-title":"MiR-143 acts as a tumor suppressor by targeting N-RAS and enhances temozolomide-induced apoptosis in glioma","volume":"5","author":"Wang","year":"2014","journal-title":"Oncotarget"},{"key":"2019112009002834900_nlz098-B61","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1016\/j.molonc.2014.11.003","article-title":"MiR-449a exerts tumor-suppressive functions in human glioblastoma by targeting Myc-associated zinc-finger protein","volume":"9","author":"Yao","year":"2015","journal-title":"Mol Oncol"},{"key":"2019112009002834900_nlz098-B62","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1002\/glia.22743","article-title":"MicroRNA-145 as one negative regulator of astrogliosis","volume":"63","author":"Wang","year":"2015","journal-title":"Glia"}],"container-title":["Journal of Neuropathology &amp; Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jnen\/article-pdf\/78\/12\/1130\/31063296\/nlz098.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jnen\/article-pdf\/78\/12\/1130\/31063296\/nlz098.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T23:38:50Z","timestamp":1721950730000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article\/78\/12\/1130\/5609075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,23]]},"references-count":62,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2019,9,23]]},"published-print":{"date-parts":[[2019,12,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jnen\/nlz098","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"value":"0022-3069","type":"print"},{"value":"1554-6578","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,12]]},"published":{"date-parts":[[2019,9,23]]}}}