{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T14:59:55Z","timestamp":1787497195123,"version":"build-2736575974"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T00:00:00Z","timestamp":1575936000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Hydrocephalus is a rare and devastating complication of mumps encephalitis. The histopathological correlates of mumps infection in central nervous system tissues are not well-characterized. We present the case of a 54-year-old patient who suffered long-term neuropsychiatric sequelae and hydrocephalus as a consequence of a childhood mumps infection. Brain autopsy revealed significant dilation of the lateral and third ventricles. Aqueductal stenosis was not observed on premortem imaging or on gross examination. Histology revealed loss of ependymal epithelium throughout the aqueduct and ventricular system. Macrophage conglomerates were identified within the cerebral aqueduct at the level of the pons in addition to subjacent periaqueductal gliosis and scattered Rosenthal fibers. Together, these findings support primary ependymal injury as a pathophysiological mechanism in the development of chronic hydrocephalus following mumps infection. Finally, we review the existing literature and discuss potential mechanisms of disease.<\/jats:p>","DOI":"10.1093\/jnen\/nlz117","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T09:31:16Z","timestamp":1575365476000},"page":"113-117","source":"Crossref","is-referenced-by-count":7,"title":["Chronic Hydrocephalus Following Mumps Encephalitis: Neuropathological Correlates and Review"],"prefix":"10.1093","volume":"79","author":[{"given":"Cassie","family":"MacRae","sequence":"first","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Boston, Massachusetts (CM, HV); and Harvard Medical School, Boston, Massachusetts (CM, HV)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hemant","family":"Varma","sequence":"additional","affiliation":[{"name":"Beth Israel Deaconess Medical Center, Boston, Massachusetts (CM, HV); and Harvard Medical School, Boston, Massachusetts (CM, HV)"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,12,10]]},"reference":[{"key":"2024032523295726700_nlz117-B1","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/00005072-196810000-00005","article-title":"Hydrocephalus following viral infection: The pathology of aqueductal stenosis developing after experimental mumps virus infection","volume":"27","author":"Johnson","year":"1968","journal-title":"J Neuropathol Exp Neurol"},{"key":"2024032523295726700_nlz117-B2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/0303-8467(93)90011-5","article-title":"Hydrocephalus due to bilateral obstruction of the foramen of Monro: A \u2018possible\u2019 late complication of mumps encephalitis","volume":"95","author":"Lahat","year":"1993","journal-title":"Clin Neurol 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acute tetraventricular hydrocephalus complicating possible mumps meningoencephalitis","volume":"49","author":"Tastan","year":"2007","journal-title":"Pediatr Int"},{"key":"2024032523295726700_nlz117-B10","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1159\/000270157","article-title":"Acute tetraventricular hydrocephalus caused by mumps meningoencephalitis in a child","volume":"45","author":"Aydemir","year":"2009","journal-title":"Pediatr Neurosurg"},{"key":"2024032523295726700_nlz117-B11","doi-asserted-by":"crossref","first-page":"179","DOI":"10.4103\/1817-1745.117871","article-title":"Hydrocephalus due to aqueductal stenosis in a case of mumps meningoencephalitis: A rare complication","volume":"8","author":"Pongener","year":"2013","journal-title":"J Pediatr Neurosci"},{"key":"2024032523295726700_nlz117-B12","first-page":"61","article-title":"No vaccine-no protection: Mumps meningoencephalitis and hydrocephalus in an unvaccinated adult","volume":"106","author":"Burns","year":"2013","journal-title":"Ir Med J"},{"key":"2024032523295726700_nlz117-B13","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1212\/WNL.0000000000000081","article-title":"Pearls & Oy-sters: Chronic mumps meningoencephalitis with low CSF glucose and acute hydrocephalus in an adult","volume":"82","author":"Escalza-Cortina","year":"2014","journal-title":"Neurology"},{"key":"2024032523295726700_nlz117-B14","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0387-7604(12)80352-4","article-title":"Hydrocephalus due to acute aqueductal stenosis following mumps infection: Report of a case and review of the literature","volume":"14","author":"Ogata","year":"1992","journal-title":"Brain Dev"},{"key":"2024032523295726700_nlz117-B15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00005072-199501000-00001","article-title":"Ependymal reactions to injury. A review","volume":"54","author":"Sarnat","year":"1995","journal-title":"J Neuropathol Exp Neurol"}],"container-title":["Journal of Neuropathology &amp; Experimental Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jnen\/article-pdf\/79\/1\/113\/31495689\/nlz117.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jnen\/article-pdf\/79\/1\/113\/31495689\/nlz117.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T19:40:20Z","timestamp":1711395620000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article\/79\/1\/113\/5651085"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,10]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,12,10]]},"published-print":{"date-parts":[[2020,1,1]]}},"URL":"https:\/\/doi.org\/10.1093\/jnen\/nlz117","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"value":"0022-3069","type":"print"},{"value":"1554-6578","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,1]]},"published":{"date-parts":[[2019,12,10]]}}}