{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T09:36:15Z","timestamp":1793957775464,"version":"4.8.0"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"NIA\/NIH","award":["U01 AG016976"],"award-info":[{"award-number":["U01 AG016976"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30 AG028383"],"award-info":[{"award-number":["P30 AG028383"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 AG057187"],"award-info":[{"award-number":["R01 AG057187"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R21 AG061551"],"award-info":[{"award-number":["R21 AG061551"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Recently, a consensus working group provided new terminology for a common disease entity, limbic predominant age-related TDP-43 encephalopathy (LATE), and its neuropathological substrate (LATE-NC). LATE-NC not only often co-occurs with Alzheimer disease neuropathological change (ADNC), but also may present in isolation. The present study aimed to investigate potential risk factors and neuropathological characteristics associated with LATE-NC. A sample of 616 autopsied participants (&amp;gt;75\u2009years at death), with TDP-43 immunohistochemical studies performed, was obtained from the National Alzheimer\u2019s Coordinating Center. Logistic regression analyses examined associations between demographic, clinical and neuropathological characteristics and LATE-NC (TDP-43 in amygdala, hippocampus, or entorhinal\/inferior temporal cortex) (alpha\u2009=\u20090.05). Adjusted models indicated that ADNC, hippocampal sclerosis (HS), arteriolosclerosis, and limbic or amygdala-predominant Lewy body disease (LBD), but not other LBD subtypes, were associated with higher odds of LATE-NC, whereas congestive heart failure (CHF) and motor problems as first predominant symptom were associated with lower odds of LATE-NC. Our findings corroborate previous studies indicating associations between LATE-NC and ADNC, HS, and arteriolosclerosis. Novel findings suggest the association with LATE-NC is restricted to amygdala\/limbic-predominant subtype of LBD, and a possible protective (or competing risk) association with CHF. This study may inform future hypothesis-driven research on LATE-NC, a common brain disease of aging.<\/jats:p>","DOI":"10.1093\/jnen\/nlz126","type":"journal-article","created":{"date-parts":[[2019,12,17]],"date-time":"2019-12-17T15:47:28Z","timestamp":1576597648000},"page":"305-313","source":"Crossref","is-referenced-by-count":100,"title":["Limbic Predominant Age-Related TDP-43 Encephalopathy (LATE): Clinical and Neuropathological Associations"],"prefix":"10.1093","volume":"79","author":[{"given":"Lilah M","family":"Besser","sequence":"first","affiliation":[{"name":"Institute for Human Health and Disease Intervention (I-HEALTH), School of Urban and Regional Planning, Florida Atlantic University From the , Boca Raton, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merilee A","family":"Teylan","sequence":"additional","affiliation":[{"name":"National Alzheimer\u2019s Coordinating Center, Department of Epidemiology, University of Washington , Seattle, Washington"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter T","family":"Nelson","sequence":"additional","affiliation":[{"name":"Sanders-Brown Center on Aging, Division of Neuropathology, Department of Pathology, University of Kentucky , Lexington, Kentucky"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,11,28]]},"reference":[{"key":"2024032523301378700_nlz126-B1","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1093\/brain\/awz099","article-title":"Limbic-predominant age-related TDP-43 encephalopathy (LATE): Consensus working group report","volume":"142","author":"Nelson","year":"2019","journal-title":"Brain"},{"key":"2024032523301378700_nlz126-B2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1007\/s00401-014-1358-z","article-title":"Hippocampal sclerosis in Lewy body disease is a TDP-43 proteinopathy similar to FTLD-TDP Type 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