{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T08:23:35Z","timestamp":1759134215291,"version":"3.37.3"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["R01 008552"],"award-info":[{"award-number":["R01 008552"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG13854"],"award-info":[{"award-number":["AG13854"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012663","name":"Davee Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012663","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Florane and Jerome Rosenstone Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Four right-handed patients who presented with an isolated impairment of speech or language had transactive response DNA-binding protein of 43 kDa (TDP-43) type B pathology. Comportment and pyramidal motor function were preserved at presentation. Three of the cases developed axial rigidity and oculomotor findings late in their course with no additional pyramidal or lower motor neuron impairments. However, in all 4 cases, postmortem examination disclosed some degree of upper and lower motor neuron disease (MND) pathology in motor cortex, brainstem, and spinal cord. Although TDP-43 type B pathology is commonly associated with MND and behavioral variant frontotemporal dementia, it is less recognized as a pathologic correlate of primary progressive aphasia and\/or apraxia of speech as the presenting syndrome. These cases, taken together, contribute to the growing heterogeneity in clinical presentations associated with TDP pathology. Additionally, 2 cases demonstrated left anterior temporal lobe atrophy but without word comprehension impairments, shedding light on the relevance of the left temporal tip for single-word comprehension.<\/jats:p>","DOI":"10.1093\/jnen\/nlz132","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T14:18:35Z","timestamp":1580307515000},"page":"277-283","source":"Crossref","is-referenced-by-count":8,"title":["Speech and Language Presentations of FTLD-TDP Type B Neuropathology"],"prefix":"10.1093","volume":"79","author":[{"given":"Daniel J","family":"Lee","sequence":"first","affiliation":[{"name":"Cognitive Neurology and Alzheimer\u2019s Disease From the Mesulam Center for"},{"name":"Department of Neurology"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eileen H","family":"Bigio","sequence":"additional","affiliation":[{"name":"Cognitive Neurology and Alzheimer\u2019s Disease From the Mesulam Center for"},{"name":"Department of 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