{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T22:45:07Z","timestamp":1788389107200,"version":"build-2803163510"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,12,9]],"date-time":"2019-12-09T00:00:00Z","timestamp":1575849600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Whatever the cause of myelin damage of the peripheral nervous system, the initial attack on myelin by a dysimmune process may begin either at the internodal area or in the paranodal and nodal regions. The term \u201cnodo-paranodopathy\u201d was first applied to some \u201caxonal Guillain-Barr\u00e9 syndrome\u201d subtypes, then extended to cases classified as chronic inflammatory demyelinating polyradiculoneuropathy bearing IgG4 antibodies against paranodal axoglial proteins. In these cases, paranodal dissection develops in the absence of macrophage-induced demyelination. In contrast, the mechanisms of demyelination of other dysimmune neuropathies induced by macrophages are unexplained, as no antibodies have been identified in such cases. Electron microscopy of longitudinal sections of nerve biopsies is useful to visualize and authenticate the characteristic lesions of paranodes\/nodes. However, it should be borne in mind that identical ultrastructural aspects are seen in other types of polyneuropathies: Genetic, experimental, and in a few polyneuropathies for which there is no obvious etiology. Ultrastructural nerve studies confirm the initial involvement of nodes\/paranodes in various types of acquired and genetic neuropathies. For some of them, the antibodies or the proteins involved by mutations are clearly identified such as Caspr-1, Contactin-1, NFasc155, and NFasc186; other unidentified proteins are likely to be involved as well.<\/jats:p>","DOI":"10.1093\/jnen\/nlz134","type":"journal-article","created":{"date-parts":[[2020,1,10]],"date-time":"2020-01-10T19:32:39Z","timestamp":1578684759000},"page":"247-255","source":"Crossref","is-referenced-by-count":34,"title":["Ultrastructural Lesions of Nodo-Paranodopathies in Peripheral Neuropathies"],"prefix":"10.1093","volume":"79","author":[{"given":"Jean-Michel","family":"Vallat","sequence":"first","affiliation":[{"name":"Department of Neurology, National Reference Center for \u2018Rare Peripheral Neuropathies\u2019, University Hospital From the , Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Magy","sequence":"additional","affiliation":[{"name":"Department of Neurology, National Reference Center for \u2018Rare Peripheral Neuropathies\u2019, University Hospital From the , Limoges, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Corcia","sequence":"additional","affiliation":[{"name":"Department of Neurology, ALS Reference Center, CHU Tours (Bretonneau Hospital) , Tours, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Marc","family":"Boulesteix","sequence":"additional","affiliation":[{"name":"Department of Neurology, Cahors Hospital , Cahors, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Uncini","sequence":"additional","affiliation":[{"name":"Department of Neurosciences, Imaging and Clinical Sciences , University \u201cG. d\u2019Annunzio\u201d, Chieti-Pescara, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Mathis","sequence":"additional","affiliation":[{"name":"Department of Neurology, Nerve-Muscle Unit, CHU Bordeaux (Pellegrin University Hospital) , Bordeaux, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,12,9]]},"reference":[{"key":"2024032523304065200_nlz134-B1","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1016\/j.clinph.2013.03.025","article-title":"Nodo-paranodopathy: Beyond the demyelinating and axonal classification in anti-ganglioside antibody-mediated neuropathies","volume":"124","author":"Uncini","year":"2013","journal-title":"Clin Neurophysiol"},{"key":"2024032523304065200_nlz134-B2","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1136\/jnnp-2017-317192","article-title":"Autoimmune nodo-paranodopathies of peripheral nerve: The concept is gaining ground","volume":"89","author":"Uncini","year":"2018","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"2024032523304065200_nlz134-B3","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/BF00684474","article-title":"Demyelination and remyelination in recurrent idiopathic polyneuropathy. 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