{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T05:31:28Z","timestamp":1784784688762,"version":"3.55.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":106,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives:<\/jats:title>\n                  <jats:p>We aimed to analyze the subchronic toxicity and tissue distribution of indium after the intratracheal administration of indium-tin oxide nanoparticles (ITO NPs) to the lungs of rats.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods:<\/jats:title>\n                  <jats:p>Male Wistar rats were administered a single intratracheal dose of 10 or 20\u00a0mg In\/kg body weight (BW) of ITO NPs. The control rats received only an intratracheal dose of distilled water. A subset of rats was periodically euthanized throughout the study from 1 to 20\u00a0weeks after administration. Indium concentrations in the serum, lungs, mediastinal lymph nodes, kidneys, liver, and spleen as well as pathological changes in the lungs and kidneys were determined. Additionally, the distribution of ionic indium and indium NPs in the kidneys was analyzed using laser ablation-inductively coupled plasma mass spectrometry.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results:<\/jats:title>\n                  <jats:p>Indium concentrations in the lungs of the 2 ITO NP groups gradually decreased over the 20-week observation period. Conversely, the indium concentrations in the mediastinal lymph nodes of the 2 ITO groups increased and were several hundred times higher than those in the kidneys, spleen, and liver. Pulmonary and renal toxicities were observed histopathologically in both the ITO groups. Both indium NPs and ionic indium were detected in the kidneys, and their distributions were similar to the strong indium signals detected at the sites of inflammatory cell infiltration and tubular epithelial cells.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions:<\/jats:title>\n                  <jats:p>Our results demonstrate that intratracheal administration of 10 or 20\u00a0mg In\/kg BW of ITO NPs in male rats produces pulmonary and renal toxicities.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/joccuh\/uiae019","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T19:55:28Z","timestamp":1713297328000},"source":"Crossref","is-referenced-by-count":8,"title":["Subchronic toxicity study of indium-tin oxide nanoparticles following intratracheal administration into the lungs of rats"],"prefix":"10.1093","volume":"66","author":[{"given":"Nagisa","family":"Matsumura","sequence":"first","affiliation":[{"name":"Kyushu University Environmental Health, Graduate School of Medical Sciences, , Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-ki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Chiba University Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, , Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasumitsu","family":"Ogra","sequence":"additional","affiliation":[{"name":"Chiba University Toxicology and Environmental Health, Graduate School of Pharmaceutical Sciences, , Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Koga","sequence":"additional","affiliation":[{"name":"Kyushu University Department of Electronics, Faculty of Information Science and Electrical Engineering, , Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaharu","family":"Shiratani","sequence":"additional","affiliation":[{"name":"Kyushu University Department of Electronics, Faculty of Information Science and Electrical Engineering, , Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kasuke","family":"Nagano","sequence":"additional","affiliation":[{"name":"Nagano Toxicologic-Pathology Consulting , Hadano, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiyo","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Kyushu University Environmental Health, Graduate School of Medical Sciences, , Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"2024052809423360900_ref1","volume-title":"US Geological Survey. Mineral commodity summaries 2022"},{"issue":"3","key":"2024052809423360900_ref2","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1539\/joh.45.137","article-title":"Interstitial pneumonia developed in a worker dealing with particles containing indium-tin oxide","volume":"45","author":"Homma","year":"2003","journal-title":"J Occup Health"},{"issue":"1","key":"2024052809423360900_ref3","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1183\/09031936.04.10012704","article-title":"Pulmonary fibrosis in an individual occupationally exposed to inhaled indium-tin oxide","volume":"25","author":"Homma","year":"2005","journal-title":"Eur Respir J"},{"issue":"5","key":"2024052809423360900_ref4","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1164\/rccm.200907-1022CR","article-title":"Pulmonary alveolar proteinosis in workers at an indium processing facility","volume":"181","author":"Cummings","year":"2010","journal-title":"Am J Respir Crit Care Med"},{"issue":"10","key":"2024052809423360900_ref5","first-page":"1347","article-title":"Pulmonary alveolar proteinosis in an indium-processing worker","volume":"123","author":"Xiao","year":"2010","journal-title":"Chin Med J"},{"issue":"1","key":"2024052809423360900_ref6","doi-asserted-by":"crossref","DOI":"10.1002\/1348-9585.12165","article-title":"Indium kinetics in an indium exposed worker before and after bilateral lung transplantation","volume":"62","author":"Nakano","year":"2020","journal-title":"J Occup Health"},{"issue":"2","key":"2024052809423360900_ref7","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.jfma.2020.08.009","article-title":"Case reports of indium lung disease in Taiwan","volume":"120","author":"Tsao","year":"2021","journal-title":"J Formos Med Assoc"},{"issue":"1","key":"2024052809423360900_ref8","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13000-023-01303-1","article-title":"A case report of indium lung with progressive emphysema and fibrosis underwent lung unilateral transplantation 20 years after the end of the exposure","volume":"18","author":"Inoue","year":"2023","journal-title":"Diagn Pathol"},{"issue":"2","key":"2024052809423360900_ref9","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1183\/09031936.00020306","article-title":"Interstitial pulmonary disorders in indium-processing workers","volume":"29","author":"Chonan","year":"2007","journal-title":"Eur Respir J"},{"issue":"1","key":"2024052809423360900_ref10","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1136\/oem.2006.029124","article-title":"Exposure to hardly soluble indium compounds in ITO production and recycling plants is a new risk for interstitial lung damage","volume":"65","author":"Hamaguchi","year":"2008","journal-title":"Occup Environ Med"},{"issue":"6","key":"2024052809423360900_ref11","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1539\/joh.L9077","article-title":"Causal relationship between indium compound inhalation and effects on the lungs","volume":"51","author":"Nakano","year":"2009","journal-title":"J Occup Health"},{"issue":"5","key":"2024052809423360900_ref12","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1378\/chest.13-2484","article-title":"Five-year cohort study: emphysematous progression of indium-exposed workers","volume":"146","author":"Nakano","year":"2014","journal-title":"Chest"},{"issue":"3","key":"2024052809423360900_ref13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/1348-9585.12050","article-title":"Possibility of lung cancer risk in indium-exposed workers: an 11-year multicenter cohort study","volume":"61","author":"Nakano","year":"2019","journal-title":"J Occup Health"},{"issue":"2","key":"2024052809423360900_ref14","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1539\/joh.44.99","article-title":"Pulmonary toxicity of indium-tin oxide and indium phosphide after intratracheal instillations into the lung of hamsters","volume":"44","author":"Tanaka","year":"2002","journal-title":"J Occup Health"},{"issue":"2","key":"2024052809423360900_ref15","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/toxsci\/kfp014","article-title":"Sintered indium-tin-oxide (ITO) particles: a new pneumotoxic entity","volume":"108","author":"Lison","year":"2009","journal-title":"Toxicol Sci"},{"issue":"1","key":"2024052809423360900_ref16","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1539\/joh.L9097","article-title":"Chronic pulmonary toxicity study of indium-tin oxide and indium oxide following intratracheal instillations into the lungs of hamsters","volume":"52","author":"Tanaka","year":"2010","journal-title":"J Occup Health"},{"issue":"2","key":"2024052809423360900_ref17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1539\/joh.L10128","article-title":"Two- and 13-week inhalation toxicities of indium-tin oxide and indium oxide in rats","volume":"53","author":"Nagano","year":"2011","journal-title":"J Occup Health"},{"issue":"3","key":"2024052809423360900_ref18","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1539\/joh.10-0057-OA","article-title":"Inhalation carcinogenicity and chronic toxicity of indium-tin oxide in rats and mice","volume":"53","author":"Nagano","year":"2011","journal-title":"J Occup Health"},{"issue":"1","key":"2024052809423360900_ref19","doi-asserted-by":"crossref","first-page":"20135","DOI":"10.1149\/10701.20135ecst","article-title":"ITO conductive ink: advances in materials, preparation, and potential sensor applications","volume":"107","author":"Hiroli","year":"2022","journal-title":"ECS Trans"},{"issue":"43","key":"2024052809423360900_ref20","doi-asserted-by":"crossref","first-page":"49313","DOI":"10.1021\/acsami.2c14257","article-title":"Infrared plasmonic metamaterials based on transparent nanoparticle films of In2O3:Sn for solar-thermal shielding applications","volume":"14","author":"Matsui","year":"2022","journal-title":"ACS Appl Mater Interfaces"},{"issue":"3","key":"2024052809423360900_ref21","first-page":"419","article-title":"Assessment of occupational exposure to indium dust for indium-tin-oxide manufacturing workers","volume":"11","author":"Kim","year":"2021","journal-title":"Biomol Ther"},{"key":"2024052809423360900_ref22","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2021.117993","article-title":"Toxicokinetics and systematic responses of differently sized indium tin oxide (ITO) particles in mice via oropharyngeal aspiration exposure","volume":"290","author":"Qu","year":"2021","journal-title":"Environ Pollut"},{"key":"2024052809423360900_ref23","doi-asserted-by":"crossref","first-page":"713","DOI":"10.2147\/IJN.S338955","article-title":"Pulmonary and systemic toxicity in a rat model of pulmonary alveolar proteinosis induced by indium-tin oxide nanoparticles","volume":"17","author":"Liu","year":"2022","journal-title":"Int J Nanomedicine"},{"key":"2024052809423360900_ref24","doi-asserted-by":"crossref","first-page":"4277","DOI":"10.2147\/IJN.S380259","article-title":"Pathological comparison of rat pulmonary models induced by silica nanoparticles and indium-tin oxide nanoparticles","volume":"17","author":"Guan","year":"2022","journal-title":"Int J Nanomedicine"},{"issue":"5","key":"2024052809423360900_ref25","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1039\/C5MT00031A","article-title":"In vitro evaluation of the cellular effect of indium tin oxide nanoparticles using the human lung adenocarcinoma A549 cells","volume":"7","author":"Tabei","year":"2015","journal-title":"Metallomics"},{"issue":"1","key":"2024052809423360900_ref26","doi-asserted-by":"crossref","first-page":"10741","DOI":"10.1038\/s41598-020-67488-3","article-title":"Nitrative DNA damage in lung epithelial cells exposed to indium nanoparticles and indium ions","volume":"10","author":"Ahmed","year":"2020","journal-title":"Sci Rep"},{"issue":"1","key":"2024052809423360900_ref27","doi-asserted-by":"crossref","first-page":"A0065","DOI":"10.5702\/massspectrometry.A0065","article-title":"iQuant2: software for rapid and quantitative imaging using laser ablation-ICP mass spectrometry","volume":"7","author":"Suzuki","year":"2018","journal-title":"Mass Spectrom"},{"issue":"7","key":"2024052809423360900_ref28","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.1021\/acs.analchem.8b05632","article-title":"Simultaneous determination of size and position of silver and gold nanoparticles in onion cells using laser ablation-ICP-MS","volume":"91","author":"Yamashita","year":"2019","journal-title":"Anal Chem"},{"issue":"9","key":"2024052809423360900_ref29","doi-asserted-by":"crossref","first-page":"2817","DOI":"10.1021\/cr980430w","article-title":"Transferrin as a metal ion mediator","volume":"99","author":"Sun","year":"1999","journal-title":"Chem Rev"},{"issue":"1","key":"2024052809423360900_ref30","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1039\/b006870p","article-title":"In vivo distribution and speciation of [114mIn]InCl3 in the Wistar rat","volume":"3","author":"Van Hulle","year":"2001","journal-title":"J Environ Monit"},{"issue":"4","key":"2024052809423360900_ref31","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1007\/s00204-018-2168-1","article-title":"New interplay between interstitial and alveolar macrophages explains pulmonary alveolar proteinosis (PAP) induced by indium tin oxide particles","volume":"92","author":"Huaux","year":"2018","journal-title":"Arch Toxicol"},{"issue":"3","key":"2024052809423360900_ref32","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/0014-4800(82)90060-0","article-title":"Selective inhibition of \u03b4-aminolevulinic acid dehydratase by indium chloride in rat kidney: biochemical and ultrastructural studies","volume":"36","author":"Woods","year":"1982","journal-title":"Exp Mol Pathol"},{"issue":"5","key":"2024052809423360900_ref33","first-page":"543","article-title":"Factors affecting the toxicity of the element indium","volume":"52","author":"Castronovo","year":"1971","journal-title":"Br J Exp Pathol"},{"issue":"2","key":"2024052809423360900_ref34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1080\/01926230490422574","article-title":"A contemporary overview of chronic progressive nephropathy in the laboratory rat, and its significance for human risk assessment","volume":"32","author":"Hard","year":"2004","journal-title":"Toxicol Pathol"}],"container-title":["Journal of Occupational Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/joh\/advance-article-pdf\/doi\/10.1093\/joccuh\/uiae019\/57245447\/uiae019.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/joh\/article-pdf\/66\/1\/uiae019\/57943211\/uiae019.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/joh\/article-pdf\/66\/1\/uiae019\/57943211\/uiae019.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T09:45:28Z","timestamp":1716889528000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joh\/article\/doi\/10.1093\/joccuh\/uiae019\/7646811"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1,1]]},"references-count":34,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,4]]}},"URL":"https:\/\/doi.org\/10.1093\/joccuh\/uiae019","relation":{},"ISSN":["1348-9585"],"issn-type":[{"value":"1348-9585","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,1,1]]},"published":{"date-parts":[[2024,1,1]]},"article-number":"uiae019"}}