{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:05:32Z","timestamp":1753877132769,"version":"3.41.2"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T00:00:00Z","timestamp":1720656000000},"content-version":"vor","delay-in-days":192,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"JSPS Grant-in-Aid for Scientific Research","award":["JP21K17279"],"award-info":[{"award-number":["JP21K17279"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,1,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The American Conference of Governmental Industrial Hygienists recommends a threshold limit value-ceiling (TLV-C) of 0.1\u00a0ppb for occupational exposure to ortho-phthalaldehyde (OPA) used in washing endoscope probes. To adhere to this extremely low exposure limit, this case study aimed to reduce OPA exposure concentrations of workers during immersion washing of an endoscope probe body. This was achieved by attaching a new duct and hood to the existing ceiling exhaust system.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The type of hood was determined by calculating and comparing the capture velocity obtained by assuming either an exterior or an enclosing hood. Additionally, the effect on improving the working environment was tested before and after the installation of the hood by measuring the OPA vapor concentration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The calculated capture velocities of the exterior and enclosing hoods were 0.05\u00a0m\/s and 0.19\u00a0m\/s, respectively. Considering the operability, the exterior hood was more appropriate; however, the calculated capture velocity indicated potential inadequacy in meeting the TLV-C requirement, leading to the adoption of the enclosing hood. The OPA vapor concentration in ceiling value measurements taken after the enclosing hood was fitted was reduced to 0.2\u00a0ppb, that is, 1\/10 of the original concentration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Although the environmental concentration after the improvement still exceeded the TLV-C of 0.1\u00a0ppb, this study\u2019s findings indicate that even substances with extremely low occupational exposure limits can be managed with appropriate local exhaust ventilation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/joccuh\/uiae033","type":"journal-article","created":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T19:10:55Z","timestamp":1720725055000},"source":"Crossref","is-referenced-by-count":0,"title":["Reducing exposure levels of immersion washing workers to <i>ortho<\/i>-phthalaldehyde by improving exhaust systems"],"prefix":"10.1093","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0523-1794","authenticated-orcid":false,"given":"Shinobu","family":"Yamamoto","sequence":"first","affiliation":[{"name":"University of Occupational and Environmental Health Department of Environmental Measurement and Control, School of Health Sciences, , Kitakyushu , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuriko","family":"Hachiya","sequence":"additional","affiliation":[{"name":"University of Occupational and Environmental Health Department of Occupational and Community Health Nursing, School of Health Sciences, , Kitakyushu , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motohide","family":"Goto","sequence":"additional","affiliation":[{"name":"University of Occupational and Environmental Health Department of Occupational Toxicology, Institute of Industrial Ecological Sciences, , Kitakyushu , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akito","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Japan Industrial Safety and Health Association Osaka Occupational Health Service Center, , Nishi-ku , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Ishidao","sequence":"additional","affiliation":[{"name":"University of Occupational and Environmental Health Department of Environmental Measurement and Control, School of Health Sciences, , Kitakyushu , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Hori","sequence":"additional","affiliation":[{"name":"University of Occupational and Environmental Health , Kitakyushu , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Miyauchi","sequence":"additional","affiliation":[{"name":"University of Occupational and Environmental Health Department of Environmental Measurement and Control, School of Health Sciences, , Kitakyushu , Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,7,11]]},"reference":[{"key":"2024082913385539700_ref1","first-page":"1","volume-title":"2019 Supplement to the Documentation of the Threshold Limit Values and Biological Exposure Indices","author":"American Conference of Governmental Industrial Hygienists (ACGIH)","year":"2019","edition":"7th"},{"issue":"1","key":"2024082913385539700_ref2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1539\/sangyoeisei.49.1","article-title":"Health hazards from exposure to ortho-phthalaldehyde, a disinfectant for endoscope, and preventative measures for health care workers","volume":"49","author":"Fujita","year":"2007","journal-title":"Sangyo Eiseigaku Zasshi"},{"issue":"2","key":"2024082913385539700_ref3","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1539\/sangyoeisei.B9013","article-title":"Ortho-phthalaldehyde exposure levels among endoscope disinfection workers","volume":"52","author":"Miyajima","year":"2010","journal-title":"Sangyo Eiseigaku Zasshi"},{"volume-title":"2023 TLVs and BEIs Based on the Documentation of the Threshold Limit Values for Chemical Substances and Physical Agents & Biological Exposure Indices","year":"2023","author":"American Conference of Governmental Industrial Hygienists (ACGIH)","key":"2024082913385539700_ref4"},{"issue":"4","key":"2024082913385539700_ref5","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1539\/joh.M9005","article-title":"Optimization of the determination of ortho-phthalaldehyde in air by derivatization with 2,4-dinitrophenylhydrazine (DNPH)","volume":"51","author":"Yamamoto","year":"2009","journal-title":"J Occup Health"},{"issue":"1","key":"2024082913385539700_ref6","doi-asserted-by":"crossref","DOI":"10.1002\/1348-9585.12105","article-title":"Development of a measurement method to determine the ceiling exposure concentration of ortho-phthalaldehyde handling workers","volume":"62","author":"Yamamoto","year":"2020","journal-title":"J Occup Health"},{"issue":"1","key":"2024082913385539700_ref7","doi-asserted-by":"crossref","DOI":"10.1002\/1348-9585.12139","article-title":"Evaluation of the ceiling of ortho-phthalaldehyde exposure among health care workers engaged in endoscope disinfection: a new methodology using video-exposure monitoring","volume":"62","author":"Yamamoto","year":"2020","journal-title":"J Occup Health"},{"key":"2024082913385539700_ref8","first-page":"614","article-title":"About examination of the measuring method of ortho-phthalaldehyde, and measurement of the medical spot","volume":"45","author":"Yamamoto","year":"2003","journal-title":"Sangyo Eiseigaku Zasshi"},{"key":"2024082913385539700_ref9","first-page":"55","article-title":"A case study measuring airborne ortho-phthalaldehyde concentration in a medical institution","volume":"31","author":"Honma","year":"2010","journal-title":"J Work Environ"},{"article-title":"Japan: working environment measurement standards","year":"2024.","author":"Ministry of Health, Labour, and Welfare (MHLW)","key":"2024082913385539700_ref10"},{"article-title":"Japan: working environment evaluation standards","year":"2024","author":"Ministry of Health, Labour, and Welfare (MHLW)","key":"2024082913385539700_ref11"},{"author":"Ministry of Health, Labour, and Welfare (MHLW)","key":"2024082913385539700_ref12"},{"key":"2024082913385539700_ref13","first-page":"159","volume-title":"Yasashi kyoku hai sekkei kyoushitsu sagyou kankyou kaizen gijutsu to kanki no chishiki [Introductory class to exhaust design: techniques in improving occupational environments and ventilation knowledge]","author":"Numano","year":"2014"}],"container-title":["Journal of Occupational Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/joh\/article-pdf\/66\/1\/uiae033\/58958126\/uiae033.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/joh\/article-pdf\/66\/1\/uiae033\/58958126\/uiae033.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,29]],"date-time":"2024-08-29T13:39:16Z","timestamp":1724938756000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joh\/article\/doi\/10.1093\/joccuh\/uiae033\/7712311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1,4]]}},"URL":"https:\/\/doi.org\/10.1093\/joccuh\/uiae033","relation":{},"ISSN":["1348-9585"],"issn-type":[{"type":"electronic","value":"1348-9585"}],"subject":[],"published-other":{"date-parts":[[2024,1]]},"published":{"date-parts":[[2024,1]]},"article-number":"uiae033"}}