{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T21:04:29Z","timestamp":1780607069922,"version":"3.54.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Vifor Pharma Switzerland","award":["IIS-NA2021\u20130615"],"award-info":[{"award-number":["IIS-NA2021\u20130615"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Glomerulonephritis is a common, organ-threatening manifestation in ANCA-associated vasculitis (AAV). Various clinico-histological scores have been developed assessing the risk of kidney failure, including the simplified ANCA kidney risk score (AKRiS).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study included 220 patients with biopsy-confirmed kidney involvement of granulomatosis with polyangiitis (GPA) or microscopic polyangiitis (MPA) recruited from four tertiary European referral centers. We collected biometric and clinical baseline data, disease activity parameters, AKRiS classes and histomorphological features. We examined the occurrence of a composite endpoint (ie all-cause mortality or kidney failure defined as persistent estimated glomerular filtration rate [eGFR] decline &amp;lt;15\u2005mL\/min\/1.73\u2005m\u00b2 or kidney replacement therapy after \u22656 months, respectively) within individual AKRiS and precursor risk classes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>GPA and MPA patients exhibited largely comparable baseline characteristics and treatment regimens. Histological analysis revealed that MPA biopsies showed significantly more sclerosis, interstitial fibrosis and tubular atrophy (IFTA) than their GPA counterparts. Histologically, most patients fell into focal and mixed classes, which mainly transitioned into low- and medium-risk AKRiS categories. Higher risk classifications predominantly derived from crescentic and sclerotic classes. Patients categorized as medium risk in the precursor score most frequently transitioned to lower AKRiS scores. AKRiS stratification was superior to the ANCA Renal Risk Score (ARRS) in the prediction of adverse outcomes over the entire period (AUC 0.76, C-Index 0.899).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The AKRiS score was found to be effective in predicting kidney failure and a strong composite kidney endpoint in a large European AAV cohort, despite slight differences in histological and event patterns between GPA and MPA under comparable treatment regimens.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/joneph\/aajaf019","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T13:54:29Z","timestamp":1773669269000},"page":"179-187","source":"Crossref","is-referenced-by-count":0,"title":["Risk stratification for renal outcomes in ANCA-associated vasculitides using established scores\u00a0and histopathological criteria"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9485-0969","authenticated-orcid":false,"given":"Stefan","family":"Kr\u00e4mer","sequence":"first","affiliation":[{"name":"Department of Nephrology and Clinical Immunology, RWTH Aachen University Hospital , Pauwelsstra\u00dfe 30, Aachen 52074 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0137-4464","authenticated-orcid":false,"given":"Kristian","family":"Vogt","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Clinical Immunology, RWTH Aachen University Hospital , Pauwelsstra\u00dfe 30, Aachen 52074 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7889-6156","authenticated-orcid":false,"given":"Martin","family":"Busch","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University Hospital Jena, Friedrich-Schiller University , Jena ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine III, University Hospital Jena, Friedrich-Schiller University , Jena ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7965-1273","authenticated-orcid":false,"given":"Raoul","family":"Bergner","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine A, Nephrology and Rheumatology, Municipal Hospital Ludwigshafen , Ludwigshafen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Mosberger","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine A, Nephrology and Rheumatology, Municipal Hospital Ludwigshafen , Ludwigshafen ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Neumann","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Cantonal Hospital St. Gallen , St. Gallen ,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa Maria","family":"Schreibing","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Clinical Immunology, RWTH Aachen University Hospital , Pauwelsstra\u00dfe 30, Aachen 52074 ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabian","family":"Schumbrink","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Clinical Immunology, RWTH Aachen University Hospital , Pauwelsstra\u00dfe 30, Aachen 52074 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