{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T11:53:19Z","timestamp":1781610799843,"version":"3.54.5"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T00:00:00Z","timestamp":1779840000000},"content-version":"vor","delay-in-days":87,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,6,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic kidney disease (CKD) is associated with cardiovascular disease (CVD). Exceptional parental longevity protects against CVD. We examined whether exceptional parental longevity modified the associations of kidney function and kidney aging with CVD in older adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used data from LonGenity (2008\u20132023), a cohort of Ashkenazi Jewish adults aged 65\u201395, comparing the offspring of parents with exceptional longevity to the offspring of parents with usual survival. Exceptional longevity was defined as living beyond 95 years. Kidney function was estimated using glomerular filtration rate (eGFR); CKD was defined as eGFR &amp;lt; 60\u2005mL\/min\/1.73m2. Kidney aging was assessed using kidney age gap\u2014the difference between proteomic kidney age and chronological age. Logistic and Cox regression tested associations between eGFR and kidney aging with prevalent and incident CVD, respectively. Effect modification was tested using interaction terms and stratified analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 1180 participants (mean age 76 \u00b1 7 years), 23% had CKD; median kidney age gap was \u22120.04 years (IQR: \u22120.67, 0.66); 15% had baseline CVD. eGFR and kidney aging were associated with prevalent CVD, but not incident CVD. Exceptional parental longevity did not modify the association of eGFR with prevalent or incident CVD. However, it did modify the association of kidney age gap with incident, but not prevalent, CVD. In the offspring of parents with exceptional longevity, higher kidney age gap was associated with increased incident CVD hazard (HR: 1.90; 95% CI: 1.23, 2.94), but not in the offspring of parents with usual survival (HR: 0.79 95% CI: 0.59, 1.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Kidney age gap may reflect early CVD risk in biologically resilient populations, thus warranting prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/joneph\/aajaf058","type":"journal-article","created":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T16:37:37Z","timestamp":1779899857000},"page":"298-306","source":"Crossref","is-referenced-by-count":0,"title":["Exceptional parental longevity modifies the associations of kidney function and kidney aging with cardiovascular disease"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1988-8738","authenticated-orcid":false,"given":"Laith","family":"Alzyood","sequence":"first","affiliation":[{"name":"Department of Medicine\/Division of Nephrology, Albert Einstein College of Medicine\/Montefiore Medical Center , Bronx, NY, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Medicine, Institute for Aging Research, Albert Einstein College of Medicine , Bronx, NY, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanish","family":"Sathyan","sequence":"additional","affiliation":[{"name":"Department of Neurology, Renaissance School of Medicine , Stony Brook, NY, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Aleksic","sequence":"additional","affiliation":[{"name":"Department of Medicine, Institute for Aging Research, Albert Einstein College of Medicine , Bronx, NY, United States"},{"name":"Department of Medicine\/Division of Endocrinology, Albert Einstein College of Medicine , Bronx, NY, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9247-0082","authenticated-orcid":false,"given":"Sofiya","family":"Milman","sequence":"additional","affiliation":[{"name":"Department of Medicine, Institute for Aging Research, Albert Einstein College of Medicine , Bronx, NY, United States"},{"name":"Department of Medicine\/Division of Endocrinology, Albert Einstein College of Medicine , Bronx, NY, United States"},{"name":"Department of Genetics, Albert Einstein College of Medicine , Bronx, NY ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7787-6268","authenticated-orcid":false,"given":"Nir","family":"Barzilai","sequence":"additional","affiliation":[{"name":"Department of Medicine, Institute for Aging Research, Albert Einstein College of Medicine , Bronx, NY, United States"},{"name":"Department of Medicine\/Division of Endocrinology, Albert Einstein College of Medicine , Bronx, NY, United States"},{"name":"Department of Genetics, Albert Einstein College of Medicine , Bronx, NY ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal\u00a0L","family":"Melamed","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Division of Nephrology, New York University Grossman School of Medicine, New York University Langone Medical Center , New York, NY, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine\/Division of Nephrology, Albert Einstein College of Medicine\/Montefiore Medical Center , Bronx, NY, United States"},{"name":"Department of Developmental and Molecular Biology, Albert Einstein College of Medicine , Bronx, NY, United States"},{"name":"Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine , Bronx, NY, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,27]]},"reference":[{"key":"2026061607065165700_aajaf058-B1","doi-asserted-by":"publisher","first-page":"745","DOI":"10.1681\/ASN.V133745","article-title":"Renal insufficiency and subsequent death resulting from cardiovascular disease in the United States","volume":"13","author":"Muntner","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"2026061607065165700_aajaf058-B2","doi-asserted-by":"publisher","first-page":"1507","DOI":"10.1161\/CIRCULATIONAHA.122.060700","article-title":"Mild-to-moderate kidney dysfunction and cardiovascular disease: observational and Mendelian randomization analyses","volume":"146","author":"Gaziano","year":"2022","journal-title":"Circulation"},{"key":"2026061607065165700_aajaf058-B3","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1038\/nrneph.2016.163","article-title":"The global burden of chronic kidney disease: estimates, variability and pitfalls","volume":"13","author":"Glassock","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"2026061607065165700_aajaf058-B4","doi-asserted-by":"publisher","first-page":"274","DOI":"10.1111\/j.1532-5415.2004.52068.x","article-title":"Clinical phenotype of families with longevity","volume":"52","author":"Atzmon","year":"2004","journal-title":"J Am Geriatr Soc"},{"key":"2026061607065165700_aajaf058-B5","doi-asserted-by":"publisher","first-page":"2170","DOI":"10.1016\/j.amjcard.2017.08.040","article-title":"Effect of exceptional parental longevity and lifestyle factors on prevalence of cardiovascular disease in offspring","volume":"120","author":"Gubbi","year":"2017","journal-title":"Am J Cardiol"},{"key":"2026061607065165700_aajaf058-B6","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1038\/s41420-023-01792-5","article-title":"Cardiac cell senescence: molecular mechanisms, key proteins and therapeutic targets","volume":"10","author":"Luan","year":"2024","journal-title":"Cell Death Discov"},{"key":"2026061607065165700_aajaf058-B7","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1093\/gerona\/glu121","article-title":"Circulating proteomic signatures of chronological age","volume":"70","author":"Menni","year":"2015","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2026061607065165700_aajaf058-B8","doi-asserted-by":"publisher","first-page":"e13256","DOI":"10.1111\/acel.13256","article-title":"Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging","volume":"19","author":"Lehallier","year":"2020","journal-title":"Aging Cell"},{"key":"2026061607065165700_aajaf058-B9","doi-asserted-by":"publisher","first-page":"e13250","DOI":"10.1111\/acel.13250","article-title":"Plasma proteomic profile of age, health span, and all-cause mortality in older adults","volume":"19","author":"Sathyan","year":"2020","journal-title":"Aging Cell"},{"key":"2026061607065165700_aajaf058-B10","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1038\/s41586-023-06802-1","article-title":"Organ aging signatures in the plasma proteome track health and disease","volume":"624","author":"Oh","year":"2023","journal-title":"Nature"},{"key":"2026061607065165700_aajaf058-B11","doi-asserted-by":"publisher","first-page":"1583","DOI":"10.1111\/jgs.14222","article-title":"Compression of morbidity is observed across cohorts with exceptional longevity","volume":"64","author":"Ismail","year":"2016","journal-title":"J Am Geriatr Soc"},{"key":"2026061607065165700_aajaf058-B12","doi-asserted-by":"publisher","first-page":"2994","DOI":"10.1681\/ASN.2021070988","article-title":"A unifying approach for GFR estimation: recommendations of the NKF-ASN task force on reassessing the inclusion of race in diagnosing kidney disease","volume":"32","author":"Delgado","year":"2021","journal-title":"J Am Soc Nephrol"},{"key":"2026061607065165700_aajaf058-B13","doi-asserted-by":"publisher","first-page":"137","DOI":"10.7326\/0003-4819-139-2-200307150-00013","article-title":"National kidney foundation practice guidelines for chronic kidney disease: evaluation, classification, and stratification","volume":"139","author":"Levey","year":"2003","journal-title":"Ann Intern Med"},{"key":"2026061607065165700_aajaf058-B14","doi-asserted-by":"publisher","first-page":"1318","DOI":"10.1126\/science.aaz1776","article-title":"The GTEx consortium atlas of genetic regulatory effects across human tissues","volume":"369","author":"Consortium","year":"2020","journal-title":"Science"},{"key":"2026061607065165700_aajaf058-B15","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1038\/s41576-022-00511-7","article-title":"Measuring biological age using omics data","volume":"23","author":"Rutledge","year":"2022","journal-title":"Nat Rev Genet"},{"key":"2026061607065165700_aajaf058-B16","first-page":"21","article-title":"Four factor index of social status","volume":"8","author":"Hollingshead","year":"1975","journal-title":"Yale J Sociol"},{"key":"2026061607065165700_aajaf058-B17","doi-asserted-by":"publisher","first-page":"1658","DOI":"10.1161\/CIRCULATIONAHA.107.739714","article-title":"Abdominal obesity and the risk of all-cause, cardiovascular, and cancer mortality: sixteen years of follow-up in US women","volume":"117","author":"Zhang","year":"2008","journal-title":"Circulation"},{"key":"2026061607065165700_aajaf058-B18","doi-asserted-by":"publisher","first-page":"932","DOI":"10.1093\/eurheartj\/ehn018","article-title":"Risk factors for myocardial infarction in women and men: insights from the INTERHEART study","volume":"29","author":"Anand","year":"2008","journal-title":"Eur Heart J"},{"key":"2026061607065165700_aajaf058-B19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.2307\/2061656","article-title":"Ever since Gompertz","volume":"34","author":"Olshansky","year":"1997","journal-title":"Demography"},{"key":"2026061607065165700_aajaf058-B20","doi-asserted-by":"publisher","first-page":"e159","DOI":"10.1016\/S2468-2667(19)30019-2","article-title":"Measuring population ageing: an analysis of the Global Burden of Disease Study 2017","volume":"4","author":"Chang","year":"2019","journal-title":"Lancet Public Health"},{"key":"2026061607065165700_aajaf058-B21","doi-asserted-by":"publisher","first-page":"826","DOI":"10.3390\/cells8080826","article-title":"WNT signaling in disease","volume":"8","author":"Ng","year":"2019","journal-title":"Cells"},{"key":"2026061607065165700_aajaf058-B22","doi-asserted-by":"publisher","first-page":"e1005728","DOI":"10.1371\/journal.pgen.1005728","article-title":"Genome-wide scan informed by age-related disease identifies loci for exceptional human longevity","volume":"11","author":"Fortney","year":"2015","journal-title":"PLoS Genet"},{"key":"2026061607065165700_aajaf058-B23","doi-asserted-by":"publisher","first-page":"3660","DOI":"10.1111\/jgs.18046","article-title":"Age-adapted eGFR thresholds underestimate the risks beyond kidney failure associated with CKD in older populations","volume":"70","author":"Lees","year":"2022","journal-title":"J Am Geriatr Soc"},{"key":"2026061607065165700_aajaf058-B24","doi-asserted-by":"publisher","first-page":"2415","DOI":"10.3390\/nu13072415","article-title":"Frequency and characteristics of overestimated renal function in Japanese patients with chronic liver disease and its relation to sarcopenia","volume":"13","author":"Yoshida","year":"2021","journal-title":"Nutrients"},{"key":"2026061607065165700_aajaf058-B25","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1159\/000541832","article-title":"Kidney and cardiovascular outcomes in older population with mildly to moderately decreased kidney function: a nationwide cohort study","volume":"56","author":"Jeon","year":"2025","journal-title":"Am J Nephrol"},{"key":"2026061607065165700_aajaf058-B26","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/s13148-024-01694-y","article-title":"DNA methylation in peripheral blood is associated with renal aging and renal function decline: a national community study","volume":"16","author":"Yang","year":"2024","journal-title":"Clin Epigenetics"},{"key":"2026061607065165700_aajaf058-B27","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","article-title":"Inflammaging: a new immune-metabolic viewpoint for age-related diseases","volume":"14","author":"Franceschi","year":"2018","journal-title":"Nat Rev Endocrinol"},{"key":"2026061607065165700_aajaf058-B28","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1159\/000452880","article-title":"Klotho\/FGF23 axis in chronic kidney disease and cardiovascular disease","volume":"3","author":"Lu","year":"2017","journal-title":"Kidney Dis (Basel)"},{"key":"2026061607065165700_aajaf058-B29","doi-asserted-by":"publisher","first-page":"sfae255","DOI":"10.1093\/ckj\/sfae255","article-title":"The association between klotho and kidney and cardiovascular outcomes: a comprehensive systematic review and meta-analysis","volume":"17","author":"Kanbay","year":"2024","journal-title":"Clin Kidney J"},{"key":"2026061607065165700_aajaf058-B30","doi-asserted-by":"publisher","first-page":"e170","DOI":"10.1371\/journal.pcbi.0030170","article-title":"Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging","volume":"3","author":"Bergman","year":"2007","journal-title":"PLoS Comput Biol"},{"key":"2026061607065165700_aajaf058-B31","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/ki.2010.483","article-title":"The definition, classification, and prognosis of chronic kidney disease: a KDIGO controversies conference report","volume":"80","author":"Levey","year":"2011","journal-title":"Kidney Int"},{"key":"2026061607065165700_aajaf058-B32","doi-asserted-by":"publisher","first-page":"e2148940","DOI":"10.1001\/jamanetworkopen.2021.48940","article-title":"Association of intraindividual difference in estimated glomerular filtration rate by creatinine vs cystatin C and End-stage kidney disease and mortality","volume":"5","author":"Chen","year":"2022","journal-title":"JAMA Netw Open"},{"key":"2026061607065165700_aajaf058-B33","doi-asserted-by":"publisher","first-page":"2030","DOI":"10.1001\/jama.290.15.2030","article-title":"Unique lipoprotein phenotype and genotype associated with exceptional longevity","volume":"290","author":"Barzilai","year":"2003","journal-title":"JAMA"},{"key":"2026061607065165700_aajaf058-B34","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.mad.2004.08.026","article-title":"Biological evidence for inheritance of exceptional longevity","volume":"126","author":"Atzmon","year":"2005","journal-title":"Mech Ageing Dev"},{"key":"2026061607065165700_aajaf058-B35","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1001\/jama.2011.451","article-title":"A predictive model for progression of chronic kidney disease to kidney failure","volume":"305","author":"Tangri","year":"2011","journal-title":"JAMA"},{"key":"2026061607065165700_aajaf058-B36","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1093\/ndt\/gfn698","article-title":"A clinical score to predict 6-month prognosis in elderly patients starting dialysis for end-stage renal disease","volume":"24","author":"Couchoud","year":"2009","journal-title":"Nephrol Dial Transplant"}],"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/joneph\/article-pdf\/39\/2\/298\/68412274\/aajaf058.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/joneph\/article-pdf\/39\/2\/298\/68412274\/aajaf058.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T11:13:48Z","timestamp":1781608428000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/article\/39\/2\/298\/8696282"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":36,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2026,5,27]]},"published-print":{"date-parts":[[2026,6,16]]}},"URL":"https:\/\/doi.org\/10.1093\/joneph\/aajaf058","relation":{},"ISSN":["1121-8428","1724-6059"],"issn-type":[{"value":"1121-8428","type":"print"},{"value":"1724-6059","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2026,3]]}}}