{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:01:50Z","timestamp":1785456110091,"version":"3.56.0"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":48,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Preimplantation genetic diagnosis for monogenic disorders makes it possible to identify and select embryos free of specific genetic mutations prior to uterine transfer, using embryos produced via medically assisted reproductive technologies. Since 2015, the Italian legal system has allowed parents who are carriers of, or affected by, monogenic hereditary conditions, including autosomal dominant polycystic kidney disease (ADPKD), to access preimplantation genetic diagnosis.<\/jats:p>\n                  <jats:p>However, the experience remains limited, and its application in particular to a late onset disease like ADPKD raises clinical and ethical concerns. These include the potential health risks associated with assisted reproductive technologies for the woman, the risk of assisted reproductive technology failure, moral permissibility of embryo selection, psychosocial implications for the couple and child, and issues related to equitable access to these treatments.<\/jats:p>\n                  <jats:p>An effective preconception counseling strategy should be grounded in a shared decision-making framework involving the prospective parents and a multidisciplinary medical team, including specialists in nephrology, obstetrics, and human genetics.<\/jats:p>\n                  <jats:p>This review aims to discuss the principal bioethical considerations surrounding preimplantation genetic diagnosis for ADPKD, in order to support clinicians involved in genetic counseling and reproductive decision-making.<\/jats:p>","DOI":"10.1093\/joneph\/aajag051","type":"journal-article","created":{"date-parts":[[2026,2,27]],"date-time":"2026-02-27T12:40:02Z","timestamp":1772196002000},"page":"455-467","source":"Crossref","is-referenced-by-count":0,"title":["ADPKD, pregnancy and preimplantation selection: clinical and bioethical considerations"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9354-0945","authenticated-orcid":false,"given":"Diana","family":"Zarantonello","sequence":"first","affiliation":[{"name":"Department of Nephrology, Santa Chiara Hospital, ASUIT , Trento ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2632-4009","authenticated-orcid":false,"given":"Giorgina Barbara","family":"Piccoli","sequence":"additional","affiliation":[{"name":"Nephrology, Department of Internal Medicine, Centre Hospitalier du Mans , Le Mans ,","place":["France"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Zuccarello","sequence":"additional","affiliation":[{"name":"Unit of Medical Genetics and Genomics, San Bortolo Hospital, AULSS8 Berica , Vicenza ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Tescaro","sequence":"additional","affiliation":[{"name":"Department of Law, University of Verona , Verona ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilaria","family":"Mariani","sequence":"additional","affiliation":[{"name":"Department of Medical and Surgical Sciences, Policlinico Universitario A. Gemelli IRCCS , Rome ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Luehwink","sequence":"additional","affiliation":[{"name":"Provincial Health Authority - Autonomous Province of Trento, Assisted Reproductive Unit , Arco, ASUIT ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Brunori","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Santa Chiara Hospital, ASUIT , Trento ,","place":["Italy"]},{"name":"CISMed, University of Trento , Trento ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,5,19]]},"reference":[{"key":"2026073019512532400_aajag051-B1","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/S0140-6736(07)60601-1","article-title":"Autosomal dominant polycystic kidney disease","volume":"369","author":"Torres","year":"2007","journal-title":"Lancet"},{"key":"2026073019512532400_aajag051-B2","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/S0140-6736(18)32782-X","article-title":"Autosomal dominant polycystic kidney disease","volume":"393","author":"Cornec-Le Gall","year":"2019","journal-title":"Lancet"},{"key":"2026073019512532400_aajag051-B3","doi-asserted-by":"publisher","first-page":"1374","DOI":"10.1681\/ASN.2007010125","article-title":"Genotype-phenotype correlations in autosomal dominant and autosomal recessive polycystic kidney disease","volume":"18","author":"Rossetti","year":"2007","journal-title":"J Am Soc Nephrol"},{"key":"2026073019512532400_aajag051-B4","first-page":"GIN\/33.2.4","article-title":"Genetica e counseling genetico [genetics and genetic counseling]","volume":"33","author":"Izzi","year":"2016","journal-title":"G Ital Nefrol"},{"key":"2026073019512532400_aajag051-B5","doi-asserted-by":"publisher","first-page":"370","DOI":"10.1016\/0272-6386(95)90096-9","article-title":"A century of mortality in five large families with polycystic kidney disease","volume":"25","author":"Florijn","year":"1995","journal-title":"Am J Kidney Dis"},{"key":"2026073019512532400_aajag051-B6","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/ki.2015.59","article-title":"Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference","volume":"88","author":"Chapman","year":"2015","journal-title":"Kidney Int"},{"key":"2026073019512532400_aajag051-B7","doi-asserted-by":"publisher","first-page":"560","DOI":"10.2215\/CJN.02410508","article-title":"Quality of life in autosomal dominant polycystic kidney disease patients not yet on dialysis","volume":"4","author":"Rizk","year":"2009","journal-title":"Clin J Am Soc Nephrol"},{"key":"2026073019512532400_aajag051-B8","doi-asserted-by":"publisher","first-page":"100813","DOI":"10.1016\/j.xkme.2024.100813","article-title":"Pain and health-related quality of life in autosomal dominant polycystic kidney disease: results from a national patient-powered registry","volume":"6","author":"Hoover","year":"2024","journal-title":"Kidney Med"},{"key":"2026073019512532400_aajag051-B9","doi-asserted-by":"publisher","first-page":"2106","DOI":"10.1093\/ndt\/gfw335","article-title":"Health-related quality of life across all stages of autosomal dominant polycystic kidney disease","volume":"32","author":"Eriksson","year":"2017","journal-title":"Nephrol Dial Transplant"},{"key":"2026073019512532400_aajag051-B10","doi-asserted-by":"publisher","first-page":"989","DOI":"10.1016\/j.ekir.2023.02.1073","article-title":"OVERTURE: a worldwide, prospective, observational study of disease characteristics in patients with ADPKD","volume":"8","author":"Perrone","year":"2023","journal-title":"Kidney Int Rep"},{"key":"2026073019512532400_aajag051-B11","doi-asserted-by":"publisher","first-page":"48","DOI":"10.2215\/CJN.10250620","article-title":"Multicenter study of long-term safety of tolvaptan in later-stage autosomal dominant polycystic kidney disease","volume":"16","author":"Torres","year":"2020","journal-title":"Clin J Am Soc Nephrol"},{"key":"2026073019512532400_aajag051-B12","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/s0140-6736(98)03495-3","article-title":"Comparison of phenotypes of polycystic kidney disease types 1 and 2. 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