{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:18:13Z","timestamp":1787937493079,"version":"build-2784847793"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Scabies, caused by Sarcoptes scabiei var. hominis, is a common parasitic infestation in tropical regions. Although primarily dermatological, it can rarely trigger systemic complications such as immune complex\u2013mediated membranoproliferative glomerulonephritis (MPGN). A 14-year-old boy presented with bilateral pedal edema, facial puffiness, and reddish urine for one week. Examination revealed pruritic papular lesions over the interdigital spaces, and microscopy confirmed Sarcoptes scabiei infestation. Investigations showed nephrotic-range proteinuria (4.9\u2005g\/day), microscopic hematuria, and normal complement levels. Kidney biopsy demonstrated immune complex\u2013mediated MPGN with crescent formation. The patient was treated with topical 5% permethrin and oral ivermectin for scabies, followed by corticosteroid pulses and monthly cyclophosphamide. Complete clinical and biochemical remission occurred within six months. This case highlights scabies as a potential trigger for immune complex\u2013mediated glomerulonephritis through chronic antigenic stimulation. Scabies-associated MPGN, though rare, should be recognized as a treatable cause of immune-mediated kidney injury. Early diagnosis and combined anti-parasitic and immunosuppressive therapy can achieve complete remission.<\/jats:p>","DOI":"10.1093\/joneph\/aajag062","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:38:35Z","timestamp":1773146315000},"page":"1063-1067","source":"Crossref","is-referenced-by-count":0,"title":["Immune complex\u2013mediated membranoproliferative glomerulonephritis following scabies infestation in a child: a rare association"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-2669-9659","authenticated-orcid":false,"given":"Thotanolla Surya","family":"Prakash","sequence":"first","affiliation":[{"name":"Department of Nephrology, Sri Venkateswara Institute of Medical Sciences , Tirupati, Andhra Pradesh ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Namesh","family":"Kamat","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sri Venkateswara Institute of Medical Sciences , Tirupati, Andhra Pradesh ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeeja Jaya","family":"Janardhanan","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Sri Venkateswara Institute of Medical Sciences , Tirupati, Andhra Pradesh ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"2026082812312957800_aajag062-B1","first-page":"79","article-title":"Post-infectious glomerulonephritis following scabies infestation: case report and review of literature","volume":"27","author":"Nagaraju","year":"2017","journal-title":"Indian J Nephrol"},{"key":"2026082812312957800_aajag062-B2","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1111\/j.1469-0691.2012.03798.x","article-title":"Scabies in the developing world: its prevalence, complications and management","volume":"18","author":"Hay","year":"2012","journal-title":"Clin Microbiol Infect"},{"key":"2026082812312957800_aajag062-B3","doi-asserted-by":"publisher","first-page":"1855","DOI":"10.1681\/ASN.2008010092","article-title":"The current state of post-streptococcal glomerulonephritis","volume":"19","author":"Rodriguez-Iturbe","year":"2008","journal-title":"J Am Soc Nephrol"},{"key":"2026082812312957800_aajag062-B4","doi-asserted-by":"publisher","first-page":"33","DOI":"10.2174\/1573396315666190717114131","article-title":"Scabies: a neglected global disease","volume":"16","author":"Leung","year":"2020","journal-title":"Curr Pediatr Rev"},{"key":"2026082812312957800_aajag062-B5","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/j.semnephrol.2011.06.005","article-title":"Membranoproliferative glomerulonephritis: pathogenetic heterogeneity and proposal for a new classification","volume":"31","author":"Sethi","year":"2011","journal-title":"Semin Nephrol"},{"key":"2026082812312957800_aajag062-B6","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/md.0b013e318161b0fc","article-title":"Acute post-infectious glomerulonephritis in the modern era: experience with 86 adults and review of the literature","volume":"87","author":"Nasr","year":"2008","journal-title":"Medicine (Baltimore)"},{"key":"2026082812312957800_aajag062-B7","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.kint.2016.09.033","article-title":"Infection-associated glomerulonephritis: mechanisms and management","volume":"91","author":"Rodr\u00edguez-Iturbe","year":"2017","journal-title":"Kidney Int"}],"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/joneph\/article-pdf\/39\/5\/1063\/68480003\/aajag062.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/joneph\/article-pdf\/39\/5\/1063\/68480003\/aajag062.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:31:32Z","timestamp":1787934692000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/article\/39\/5\/1063\/8702908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":7,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,8,28]]},"published-print":{"date-parts":[[2026,8,28]]}},"URL":"https:\/\/doi.org\/10.1093\/joneph\/aajag062","relation":{},"ISSN":["1121-8428","1724-6059"],"issn-type":[{"value":"1121-8428","type":"print"},{"value":"1724-6059","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6]]},"published":{"date-parts":[[2026,6]]}}}