{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:18:18Z","timestamp":1787937498582,"version":"build-2784847793"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"vor","delay-in-days":66,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Peritoneal membrane thickening is a structural feature of chronic peritoneal stress in long-term peritoneal dialysis (PD). Its non-invasive evaluation remains limited. This study explored the associations between ultrasound-based peritoneal membrane thickness assessment, inflammatory markers, and technique outcomes in PD patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this prospective study, 106 PD patients underwent standardized ultrasonographic measurements of peritoneal membrane thickness across four abdominal quadrants. Serum and dialysate levels of interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) were analyzed as markers of systemic and local inflammation. Relationships between peritoneal membrane thickness and clinical parameters were examined. Patients were followed for 24 months to evaluate technique failure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Median peritoneal membrane thickness was 0.30\u2005mm (Interquartile range [IQR]:0.28\u20130.37). Peritoneal membrane thickness showed positive correlations with serum and dialysate IL-6 (r = 0.42 and 0.39; P &amp;lt; .01) and dialysate MCP-1 (r = 0.36; P &amp;lt; .05). Thicker membranes were observed in patients with longer PD duration and higher glucose exposure (P &amp;lt; .01). Individuals with prior peritonitis had greater peritoneal membrane thickness (0.45\u2005mm vs 0.29\u2005mm, P &amp;lt; .001). Patients with low transport status tended to have greater peritoneal membrane thickness, largely related to longer PD vintage. In multivariable Cox regression analysis, greater ultrasonographic peritoneal membrane thickness (modeled as a continuous variable) was independently associated with a higher risk of technique failure (Hazard ratio [HR] 31.3, 95% confidence interval [CI] 2.54\u2013385.33).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Ultrasonographic peritoneal membrane thickness appears to reflect both local and systemic inflammation and may indicate cumulative peritoneal stress. Its assessment\u00a0could provide a feasible, non-invasive approach to monitor peritoneal integrity and identify patients at risk of technique failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/joneph\/aajag069","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T12:59:10Z","timestamp":1773233950000},"page":"988-996","source":"Crossref","is-referenced-by-count":0,"title":["Ultrasound-based peritoneal membrane thickness as a marker of inflammation and technique failure in peritoneal dialysis"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2693-1167","authenticated-orcid":false,"given":"Saliha","family":"Y\u0131ld\u0131r\u0131m","sequence":"first","affiliation":[{"name":"Department of Nephrology, Gazi University Faculty of Medicine , Ankara 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