{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:18:18Z","timestamp":1787937498600,"version":"build-2784847793"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T00:00:00Z","timestamp":1782432000000},"content-version":"vor","delay-in-days":25,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disorder globally, and early identification of affected family members is essential. The goal of this study was to investigate family screening uptake among relatives of ADPKD patients and to identify patient-level factors affecting screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional study was conducted at Etlik City Hospital, Ankara, with the approval of the local ethics committee. Sociodemographic data, clinical parameters, and family screening outcomes were collected, and health literacy was assessed using Tu\u0308rkiye Sa\u011fl\u0131k Okuryazarl\u0131\u011f\u0131 \u00d6l\u00e7e\u011fi-32 (TS\u00d6Y-32). Screening outcomes were defined as relatives who had been screened, expressed willingness to be screened, and refused screening. Analyses included descriptive statistics, Spearman correlations, chi-square tests, binary logistic regression, interaction modeling, and fractional logistic regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 395 relatives of 68 patients, 234 (59%) had been screened, 56 (14%) expressed willingness, and 105 (27%) declined. Higher health literacy (TS\u00d6Y-32) scores correlated with greater screening uptake (\u03c1 = 0.77, P &amp;lt; .001). In multivariable logistic regression, TS\u00d6Y-32 was the only independent predictor (odds ratio [OR] 1.26, 95% confidence interval [CI] 1.07\u20131.49, P = .005). Each 1-point increase in TS\u00d6Y-32 was associated with a 14% increase in screening odds (OR 1.14, 95% CI 1.09\u20131.20, P &amp;lt; .001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Family screening uptake remains suboptimal. Health literacy was the strongest predictor of screening. Interventions incorporating health literacy assessment, patient-centered counseling, and systematic screening opportunities are needed.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/joneph\/aajag072","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:47:48Z","timestamp":1773330468000},"page":"997-1004","source":"Crossref","is-referenced-by-count":0,"title":["Family-based screening for polycystic kidney disease: the role of health literacy"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0834-900X","authenticated-orcid":false,"given":"Berrak It\u0131r","family":"Ayl\u0131","sequence":"first","affiliation":[{"name":"Institute\u00a0of Health Sciences, Department of Public Health, Hacettepe University , Ankara ,","place":["T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2606-3865","authenticated-orcid":false,"given":"Ebru","family":"G\u00f6k O\u011fuz","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University of Health Sciences, Etlik City Hospital , Ankara ,","place":["T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8004-4342","authenticated-orcid":false,"given":"N\u00fcket","family":"Paksoy Erbaydar","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Department of Public Health, Hacettepe University , Ankara ,","place":["T\u00fcrkiye"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"2026082812320068400_aajag072-B1","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1016\/S0140-6736(07)60601-1","article-title":"Autosomal dominant polycystic kidney disease","volume":"369","author":"Torres","year":"2007","journal-title":"Lancet"},{"key":"2026082812320068400_aajag072-B2","doi-asserted-by":"publisher","first-page":"sfae405","DOI":"10.1093\/ckj\/sfae405","article-title":"The ERA registry annual report 2022: epidemiology of kidney replacement therapy in Europe, with a focus on sex comparisons","volume":"18","author":"Boenink","year":"2024","journal-title":"Clin Kidney J"},{"key":"2026082812320068400_aajag072-B3","author":"T\u00fcrk Nefroloji Derne\u011fi"},{"key":"2026082812320068400_aajag072-B4","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nrneph.2010.18","article-title":"Molecular diagnostics for autosomal dominant polycystic kidney disease","volume":"6","author":"Harris","year":"2010","journal-title":"Nat Rev Nephrol"},{"key":"2026082812320068400_aajag072-B5","doi-asserted-by":"publisher","first-page":"479","DOI":"10.2215\/CJN.09500911","article-title":"Kidney volume and functional outcomes in autosomal dominant polycystic kidney disease","volume":"7","author":"Chapman","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"key":"2026082812320068400_aajag072-B6","doi-asserted-by":"publisher","first-page":"1042","DOI":"10.1053\/j.ajkd.2008.05.015","article-title":"Presence of de novo mutations in autosomal dominant polycystic kidney disease patients without family history","volume":"52","author":"Reed","year":"2008","journal-title":"Am J Kidney Dis"},{"key":"2026082812320068400_aajag072-B7","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1038\/ki.2015.59","article-title":"Autosomal-dominant polycystic kidney disease (ADPKD): executive summary from a Kidney Disease: Improving Global Outcomes (KDIGO) controversies conference","volume":"88","author":"Chapman","year":"2015","journal-title":"Kidney Int"},{"key":"2026082812320068400_aajag072-B8","doi-asserted-by":"publisher","first-page":"1178","DOI":"10.1681\/ASN.V551178","article-title":"Pregnancy outcome and its relationship to progression of renal failure in autosomal dominant polycystic kidney disease","volume":"5","author":"Chapman","year":"1994","journal-title":"J Am Soc Nephrol"},{"key":"2026082812320068400_aajag072-B9","doi-asserted-by":"publisher","first-page":"2072","DOI":"10.1016\/j.socscimed.2008.09.050","article-title":"The evolving concept of health literacy","volume":"67","author":"Nutbeam","year":"2008","journal-title":"Soc Sci Med"},{"key":"2026082812320068400_aajag072-B10","doi-asserted-by":"publisher","first-page":"97","DOI":"10.7326\/0003-4819-155-2-201107190-00005","article-title":"Low health literacy and health outcomes: an updated systematic review","volume":"155","author":"Berkman","year":"2011","journal-title":"Ann Intern Med"},{"key":"2026082812320068400_aajag072-B11","doi-asserted-by":"publisher","first-page":"80","DOI":"10.1186\/1471-2458-12-80","article-title":"Health literacy and public health: a systematic review and integration of definitions and models","volume":"12","author":"S\u00f8rensen","year":"2012","journal-title":"BMC Public Health"},{"key":"2026082812320068400_aajag072-B12","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.3390\/healthcare13111316","article-title":"A diagnosis or a trap: exploring the psychosocial and ethical impacts of autosomal dominant polycystic kidney disease diagnosis","volume":"13","author":"T\u00fcrk","year":"2025","journal-title":"Healthcare (Basel)"},{"key":"2026082812320068400_aajag072-B13","doi-asserted-by":"publisher","first-page":"97\u2013","DOI":"10.5152\/turkjnephrol.2025.24865","article-title":"A cross-sectional analysis of the quality and readability of social media content on autosomal dominant polycystic kidney disease","volume":"34","author":"Koc","year":"2025","journal-title":"J Nephrol."},{"key":"2026082812320068400_aajag072-B14","doi-asserted-by":"publisher","first-page":"1354","DOI":"10.2215\/CJN.09761110","article-title":"Prevalence and demographic and clinical associations of health literacy in patients on maintenance hemodialysis","volume":"6","author":"Green","year":"2011","journal-title":"Clin J Am Soc Nephrol"},{"key":"2026082812320068400_aajag072-B15","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1681\/ASN.2009111163","article-title":"Low health literacy associates with increased mortality in ESRD","volume":"21","author":"Cavanaugh","year":"2010","journal-title":"J Am Soc Nephrol"},{"key":"2026082812320068400_aajag072-B16","volume-title":"\u201cT\u00fcrkiye Sa\u011fl\u0131k Okuryazarl\u0131\u011f\u0131 \u00d6l\u00e7ekleri G\u00fcvenilirlik ve Ge\u00e7erlilik \u00c7al\u0131\u015fmas\u0131\u201d","author":"Okyay","year":"2016"},{"key":"2026082812320068400_aajag072-B17","doi-asserted-by":"publisher","first-page":"147","DOI":"10.5527\/wjn.v5.i2.147","article-title":"Health literacy in kidney disease: review of the literature and implications for clinical practice","volume":"5","author":"Jain","year":"2016","journal-title":"World J Nephrol"},{"key":"2026082812320068400_aajag072-B18","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1681\/ASN.2014030297","article-title":"Imaging-based diagnosis of autosomal dominant polycystic kidney disease","volume":"26","author":"Pei","year":"2015","journal-title":"J Am Soc Nephrol"},{"key":"2026082812320068400_aajag072-B19","doi-asserted-by":"publisher","first-page":"397","DOI":"10.3265\/Nefrologia.pre2012.Feb.11379","article-title":"Progression of chronic kidney disease. Prevalence of anxiety and depression in autosomal dominant polycystic kidney disease","volume":"32","author":"P\u00e9rez-Dominguez","year":"2012","journal-title":"Nefrologia (Engl Ed)."},{"key":"2026082812320068400_aajag072-B20","doi-asserted-by":"publisher","first-page":"e067386","DOI":"10.1136\/bmjopen-2022-067386","article-title":"Prevalence of undiagnosed stage 3 chronic kidney disease in France, Germany, Italy, Japan and the USA: results from the multinational observational REVEAL-CKD study","volume":"13","author":"Tangri","year":"2023","journal-title":"BMJ Open"},{"key":"2026082812320068400_aajag072-B21","author":"T.C. Sa\u011fl\u0131k Bakanl\u0131\u011f\u0131 Halk Sa\u011fl\u0131\u011f\u0131 Genel M\u00fcd\u00fcrl\u00fc\u011f\u00fc"},{"key":"2026082812320068400_aajag072-B22","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1016\/j.kint.2024.07.009","article-title":"KDIGO 2025 clinical practice guideline for the evaluation, management, and treatment of autosomal dominant polycystic kidney disease (ADPKD): executive summary","volume":"107","author":"Kidney Disease: Improving Global Outcomes (KDIGO) ADPKD Work Group","year":"2025","journal-title":"Kidney Int"}],"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/joneph\/article-pdf\/39\/5\/997\/68627511\/aajag072.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/joneph\/article-pdf\/39\/5\/997\/68627511\/aajag072.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:32:07Z","timestamp":1787934727000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/article\/39\/5\/997\/8718964"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2026,8,28]]},"published-print":{"date-parts":[[2026,8,28]]}},"URL":"https:\/\/doi.org\/10.1093\/joneph\/aajag072","relation":{},"ISSN":["1121-8428","1724-6059"],"issn-type":[{"value":"1121-8428","type":"print"},{"value":"1724-6059","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,6]]},"published":{"date-parts":[[2026,6]]}}}