{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T17:18:13Z","timestamp":1787937493013,"version":"build-2784847793"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Centre d\u2019Excellence African Sant\u00e9 et Environnement"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic kidney disease (CKD) is a major global public health issue, especially in low- and middle-income countries where access to laboratory testing is limited. Point-of-care tests for creatinine may offer an alternative for detection of CKD with kidney function impairment\u00a0in such settings. However, its analytical and clinical validity compared to standard laboratory methods remains uncertain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To assess the performance of a point-of-care test device for estimating glomerular filtration rate (GFR) compared to laboratory-based creatinine and cystatin C-based estimated GFR (eGFR).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional analytical study was conducted at Ouakam Military Hospital and included 405 adults undergoing routine kidney function testing. Each participant underwent point-of-care testing using the Nova StatSensor\u00ae device and standard laboratory tests for serum creatinine and cystatin C. The eGFR was calculated using the 2021 Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equations. Performance was evaluated through correlation analyses, Bland-Altman plots, Deming regression, percentage of values within \u00b130% of the reference value (P30) accuracy, and diagnostic performance using receiver operating characteristic (ROC) curves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Point-of-care tests for creatinine showed moderate correlation with laboratory serum\u00a0creatinine (r = 0.48) and respective eGFR values (r = 0.60), but consistently overestimated creatinine, leading to underestimation of eGFR (mean bias: \u221231.09\u2005mL\/min\/1.73\u2005m2). Correlation with cystatin C-based eGFR was weaker (r = 0.35), with a significant negative bias (\u221238.57\u2005mL\/min\/1.73\u2005m2). P30 accuracy was low (32.6% vs lab creatinine; 28.1% vs cystatin C). The diagnostic performance for detecting CKD stage 3 and over\u00a0(eGFR &amp;lt; 60\u2005mL\/min\/1.73 m2) demonstrated a high negative predictive value (91.3% vs 90% using cystatin C and serum creatinine, respectively, as reference).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>While point-of-care testing shows limitations for precise GFR estimation, it demonstrates utility for community-based CKD screening with high negative predictive value.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/joneph\/aajag080","type":"journal-article","created":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T12:49:20Z","timestamp":1774529360000},"page":"1042-1051","source":"Crossref","is-referenced-by-count":0,"title":["Performance of point-of-care creatinine testing in the estimation of glomerular filtration rate: comparison with laboratory creatinine and cystatin C-based measurements"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-4138-2239","authenticated-orcid":false,"given":"Ibrahima Lyra","family":"Sarr","sequence":"first","affiliation":[{"name":"Department of Nephrology, Dialysis and Kidney Transplantation, Ouakam Military Hospital , Dakar ,","place":["Senegal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheikh","family":"Faye","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Ouakam Military Hospital , Dakar ,","place":["Senegal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Modou","family":"Ndongo","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Dialysis, Amath Dansokho Hospital , Kedougou ,","place":["Senegal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babacar","family":"Mbodj","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Kidney Transplantation, Ouakam Military Hospital , Dakar ,","place":["Senegal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baratou","family":"Coundoul","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Kidney Transplantation, Ouakam Military Hospital , Dakar ,","place":["Senegal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Papa\u00a0Aly\u00a0Thiam","family":"Gueye","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Ouakam Military Hospital , Dakar ,","place":["Senegal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mame Cheikh","family":"Seck","sequence":"additional","affiliation":[{"name":"Department of Medical Biochemistry, Ouakam Military Hospital , Dakar ,","place":["Senegal"]},{"name":"Department of Parasitology, Cheikh Anta Diop University , Dakar ,","place":["Senegal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidy Mohamed","family":"Seck","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Dialysis and Kidney Transplantation, Ouakam Military Hospital , Dakar ,","place":["Senegal"]},{"name":"Faculty of Health Sciences, Gaston Berger University , Saint Louis ,","place":["Senegal"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,28]]},"reference":[{"key":"2026082812312857200_aajag080-B1","doi-asserted-by":"publisher","first-page":"e382","DOI":"10.1016\/S2214-109X(23)00570-3","article-title":"An update on the global disparities in kidney disease burden and care across world countries and regions","volume":"12","author":"Bello","year":"2024","journal-title":"Lancet Glob Health"},{"key":"2026082812312857200_aajag080-B2","doi-asserted-by":"publisher","first-page":"3519","DOI":"10.1186\/s12889-024-21065-9","article-title":"Epidemiological shifts in chronic kidney disease: a 30-year global and regional 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