{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:40:40Z","timestamp":1792633240465,"version":"4.5.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Sarcopenia is an increasingly recognized complication of chronic kidney disease (CKD), contributing to impaired physical function and higher mortality. While most evidence derives from elderly populations, its frequency and inflammatory correlates in younger adults remain underexplored. This study aimed to investigate the prevalence of sarcopenia and its association with inflammatory markers in a non-geriatric CKD cohort, including both hemodialysis and non-dialysis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This cross-sectional observational study included 128 non-geriatric CKD patients (18\u201365 years), 60 of whom were on maintenance hemodialysis. Sarcopenia was diagnosed according to EWGSOP2 criteria using handgrip strength, bioelectrical impedance analysis, and 4-meter gait-speed testing. Serum interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-\u03b1) were measured by ELISA, while C-reactive protein (CRP) served as another inflammatory marker. SPSS v27.0 was used for statistical analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Sarcopenia\u00a0was confirmed in 21.9% of the cohort, with a significantly higher prevalence among hemodialysis patients (31.7% vs 13.2%, P &amp;lt; .05). The prevalence of sarcopenia increased progressively with advancing CKD stage in the overall cohort (P &amp;lt; .05). Dialysis status was the most consistent independent predictor of sarcopenia (fully adjusted OR = 8.28, P = .004). IL-6 \u2265 110\u2005ng\/L and TNF-\u03b1 &amp;gt; 150\u2005ng\/L were associated with higher sarcopenia prevalence and lower appendicular skeletal muscle mass, respectively (P &amp;lt; .05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Sarcopenia is highly prevalent among non-geriatric CKD patients and increases with disease progression. Dialysis remains the strongest independent predictor, while elevated IL-6 and TNF-\u03b1 levels reflect inflammation-related muscle loss.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/joneph\/aajag120","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T11:47:03Z","timestamp":1777031223000},"page":"1401-1410","source":"Crossref","is-referenced-by-count":0,"title":["Association between sarcopenia and inflammation in non-geriatric patients with chronic kidney disease: a comparison of hemodialysis and non-hemodialysis patients"],"prefix":"10.1093","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-7015-6736","authenticated-orcid":false,"given":"Mert","family":"Aric","sequence":"first","affiliation":[{"name":"\u0130stanbul Training and Research Hospital, Department of Internal Medicine , \u0130stanbul 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