{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:27:05Z","timestamp":1786120025702,"version":"build-2736575974"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T00:00:00Z","timestamp":1785974400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Galectin-3 (Gal-3) regulates cell adhesion, apoptosis, inflammation, and immune activation. Recent studies on Gal-3 and renocardiac or cardiorenal syndrome (CRS) show conflicting results. This meta-analysis systematically evaluated Gal-3 in predicting CRS subtypes and mortality.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched PubMed, EMBASE, The Cochrane Library, Web of Science, and the China National Knowledge Infrastructure (CNKI) for papers investigating the relationship between serum Gal-3 levels and CRS, from database inception to July 10, 2025, with an updated search conducted on March 1, 2026. Observational studies evaluating Gal-3 in relation to CRS incidence and mortality, heart failure (HF) mortality, and chronic kidney disease (CKD) mortality were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 281 articles were retrieved, and 22 were ultimately included after screening. High Gal-3 levels significantly predicted incident HF in CKD patients (hazard ratios [HR]: 1.19; 95% confidence interval [CI]: 1.10-1.28; P&amp;lt;0.0001) and predicted all-cause mortality in CKD patients (HR: 2.45; 95% CI: 1.37-4.37; P=0.002). In HF patients, Elevated Gal-3 levels were associated with a higher risk of the occurrence of CRS (odds ratios [OR]: 1.12; 95% CI: 1.03-1.22; P=0.01) and also predicted all-cause mortality (HR: 1.55; 95% CI: 1.33-1.82; P&amp;lt;0.00001). Finally, the 2 included studies indicated that Gal-3 was significantly associated with all-cause mortality in CRS patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Gal-3 may serve as a significant predictor for the incidence of Type 2 and Type 4 CRS, the risk of mortality in HF and CKD patients, and all-cause mortality in CRS patients.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/joneph\/aajag214","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T11:53:37Z","timestamp":1786017217000},"source":"Crossref","is-referenced-by-count":0,"title":["Galectin-3 in Cardiorenal Syndrome: A Systematic Review and Meta-analysis"],"prefix":"10.1093","author":[{"given":"Yujia","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Cardiovascular, Guangzhou University of Traditional Chinese Medicine Dongguan Hospital , Dongguan 523000, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaobin","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Guangzhou University of Traditional Chinese Medicine Dongguan Hospital , Dongguan 523000, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zonglin","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Guangzhou University of Traditional Chinese Medicine Dongguan Hospital , Dongguan 523000, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhubin","family":"Lun","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Guangzhou University of Traditional Chinese Medicine Dongguan Hospital , Dongguan 523000, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiancong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Guangzhou University of Traditional Chinese Medicine Dongguan Hospital , Dongguan 523000, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xindan","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine, Dongguan Maternal and Child Health Hospital , Dongguan 523000, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peiwen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Guangzhou University of Traditional Chinese Medicine Dongguan Hospital , Dongguan 523000, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4203-8555","authenticated-orcid":false,"given":"Jianfeng","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular, Guangzhou University of Traditional Chinese Medicine Dongguan Hospital , Dongguan 523000, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,6]]},"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/joneph\/advance-article-pdf\/doi\/10.1093\/joneph\/aajag214\/70511691\/aajag214.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/joneph\/advance-article-pdf\/doi\/10.1093\/joneph\/aajag214\/70511691\/aajag214.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T19:43:04Z","timestamp":1786045384000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/advance-article\/doi\/10.1093\/joneph\/aajag214\/8753660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,6]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/joneph\/aajag214","relation":{},"ISSN":["1121-8428","1724-6059"],"issn-type":[{"value":"1121-8428","type":"print"},{"value":"1724-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,6]]},"article-number":"aajag214"}}