{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T11:21:07Z","timestamp":1787656867170,"version":"build-2736575974"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Elevated serum uric acid (UA) level is a major health risk, and its accumulation is exacerbated by impaired renal function. Physical activity is a modifiable determinant of serum UA levels. This study used an isotemporal substitution model to examine the associations of reallocating time between activity behaviors with serum UA levels in middle-aged and older adults with and without chronic kidney disease (CKD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 294 middle-aged and older adults with and without CKD (45\u201385 years) were recruited. Sedentary behavior (SB), light-intensity physical activity (LPA), and moderate-to-vigorous-intensity physical activity (MVPA) were objectively measured using a triaxial accelerometer. Serum UA levels were assessed from fasting blood samples.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Higher SB and lower LPA were significantly associated with elevated serum UA levels. In contrast, MVPA was not significantly associated with serum UA levels. In isotemporal substitution models, replacing 30 min\/day of SB with an equivalent duration of LPA was associated with lower serum UA levels (\u03b2 = \u22120.057, P = 0.008). Substituting SB with MVPA was not significantly associated with serum UA levels (\u03b2 = 0.048, P = 0.466). Stratified analyses revealed that the substitution of SB with LPA was significantly associated with lower serum UA levels among participants with CKD, whereas no significant association was observed among those without CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>SB was associated with higher serum UA levels, whereas LPA demonstrated a favorable association. Replacing 30\u2009min\/day of SB with LPA was associated with lower serum UA levels, particularly among individuals with CKD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/joneph\/aajag232","type":"journal-article","created":{"date-parts":[[2026,8,22]],"date-time":"2026-08-22T11:45:09Z","timestamp":1787399109000},"source":"Crossref","is-referenced-by-count":0,"title":["Associations of sedentary behavior and physical activity with serum uric acid in middle-aged and older adults with and without chronic kidney disease"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4362-1304","authenticated-orcid":false,"given":"Jihoon","family":"Kim","sequence":"first","affiliation":[{"name":"Institute of Health and Sport Sciences, University of Tsukuba , Ibaraki ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6001-578X","authenticated-orcid":false,"given":"Keisei","family":"Kosaki","sequence":"additional","affiliation":[{"name":"Institute of Health and Sport Sciences, University of Tsukuba , Ibaraki ,","place":["Japan"]},{"name":"Advanced Research Initiative for Human High Performance, University of Tsukuba , Ibaraki ,","place":["Japan"]},{"name":"Division of Preventive and Sports Nephrology, Graduate School of Comprehensive Human Sciences, University of Tsukuba , Ibaraki ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoya","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture , Tokyo ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masahiro","family":"Matsui","sequence":"additional","affiliation":[{"name":"Department of Child Psychiatry, Yokohama City University Hospital , Kanagawa ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaki","family":"Yoshioka","sequence":"additional","affiliation":[{"name":"Division of Mineral Metabolism, Center for Molecular Medicine, Jichi Medical University , Tochigi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichiro","family":"Oka","sequence":"additional","affiliation":[{"name":"Faculty of Sport Sciences, Waseda University , Saitama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seiji","family":"Maeda","sequence":"additional","affiliation":[{"name":"Faculty of Sport Sciences, Waseda University , Saitama ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0888-4440","authenticated-orcid":false,"given":"Yoshio","family":"Nakata","sequence":"additional","affiliation":[{"name":"Institute of Health and Sport Sciences, University of Tsukuba , Ibaraki ,","place":["Japan"]},{"name":"Advanced Research Initiative for Human High Performance, University of Tsukuba , Ibaraki ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Makoto","family":"Kuro-o","sequence":"additional","affiliation":[{"name":"Division of Mineral Metabolism, Center for Molecular Medicine, Jichi Medical University , Tochigi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7407-0410","authenticated-orcid":false,"given":"Kunihiro","family":"Yamagata","sequence":"additional","affiliation":[{"name":"Division of Preventive and Sports Nephrology, Graduate School of Comprehensive Human Sciences, University of Tsukuba , Ibaraki ,","place":["Japan"]},{"name":"Department of Nephrology, Institute of Medicine, University of Tsukuba , Ibaraki ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,25]]},"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/joneph\/advance-article-pdf\/doi\/10.1093\/joneph\/aajag232\/70782653\/aajag232.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/joneph\/advance-article-pdf\/doi\/10.1093\/joneph\/aajag232\/70782653\/aajag232.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:41:51Z","timestamp":1787654511000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/advance-article\/doi\/10.1093\/joneph\/aajag232\/8770142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,25]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/joneph\/aajag232","relation":{},"ISSN":["1121-8428","1724-6059"],"issn-type":[{"value":"1121-8428","type":"print"},{"value":"1724-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,25]]},"article-number":"aajag232"}}