{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T07:00:28Z","timestamp":1790406028649,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>AA amyloidosis is driven by persistently elevated serum amyloid A (SAA) in chronic inflammation. Severe obesity has emerged as a potential inflammatory driver of renal AA amyloidosis. We report a 47-year-old man with prior sleeve gastrectomy who developed progressive kidney dysfunction and proteinuria after substantial weight regain. At presentation, he weighed 126 kg (body mass index, 45.2 kg\/m2); serum creatinine was 4.3 mg\/dL (estimated glomerular filtration rate, 15 mL\/min\/1.73 m2) and urine albumin-to-creatinine ratio (UACR) was 3.4 g\/g. Kidney biopsy confirmed AA amyloidosis, while extensive evaluation for autoimmune, infectious, hereditary, malignant, and monoclonal causes was unrevealing. SAA was 80 mg\/L with persistently elevated inflammatory markers. Semaglutide was initiated as part of a weight-management strategy. Following a 47-kg weight loss, creatinine decreased to 2.34 mg\/dL, estimated glomerular filtration rate increased to 32 mL\/min\/1.73 m2, UACR declined to 1.0 g\/g, and SAA fell to &amp;lt;10 mg\/L, with improvement in C-reactive protein, erythrocyte sedimentation rate, and HbA1c. In the absence of another identifiable cause, the parallel improvement in SAA, systemic inflammation, proteinuria, and kidney function supports severe obesity as a potential inflammatory contributor to renal AA amyloidosis, although causality cannot be inferred from a single case.<\/jats:p>","DOI":"10.1093\/joneph\/aajag252","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:29:15Z","timestamp":1790335755000},"source":"Crossref","is-referenced-by-count":0,"title":["Renal AA amyloidosis associated with severe obesity: improvement in kidney function and proteinuria following semaglutide-associated weight loss"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4558-2152","authenticated-orcid":false,"given":"Ilker","family":"Atay","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Dokuz Eylul University School of Medicine , Izmir ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erhan","family":"Eroz","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Dokuz Eylul University School of Medicine , Izmir ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeynep","family":"Bayramo\u011flu","sequence":"additional","affiliation":[{"name":"Department of Pathology, Dokuz Eylul University School of Medicine , Izmir ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdurrahman","family":"\u00c7\u00f6mlek\u00e7i","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism, Department of Internal Medicine, Dokuz Eylul University School of Medicine , Izmir ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0597-5822","authenticated-orcid":false,"given":"Berfu","family":"Korucu","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Internal Medicine, Dokuz Eylul University School of Medicine , Izmir ,","place":["Turkey"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,26]]},"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/joneph\/advance-article-pdf\/doi\/10.1093\/joneph\/aajag252\/71400256\/aajag252.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/joneph\/advance-article-pdf\/doi\/10.1093\/joneph\/aajag252\/71400256\/aajag252.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T06:46:29Z","timestamp":1790405189000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/advance-article\/doi\/10.1093\/joneph\/aajag252\/8836399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,26]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/joneph\/aajag252","relation":{},"ISSN":["1121-8428","1724-6059"],"issn-type":[{"value":"1121-8428","type":"print"},{"value":"1724-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,26]]},"article-number":"aajag252"}}