{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:57:14Z","timestamp":1790845034478,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Kidney transplantation is the optimal treatment for end-stage renal disease (ESRD), but the persistent donor shortage necessitates expanding the donor pool, including utilizing living donors with dysglycemia. However, their post-nephrectomy safety remains inadequately characterized.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective cohort study analyzed 771 living donors (699 normal, 53 impaired fasting glucose [IFG], 19 diabetes) undergoing nephrectomy (2017-2023). The primary outcome was acute eGFR slope. Multivariable linear regression identified independent risk factors. A targeted systematic review with meta-analysis was conducted to summarize existing evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Over a median 31-month follow-up, no donors developed ESRD. Diabetic donors had a higher incidence of eGFR &amp;lt;45 ml\/min\/1.73 m2 (10.5% vs. 1.9% vs. 1.4%, P=0.041). The acute eGFR slope was steeper in diabetic donors (-17.3 vs. -14.4 vs. -13.2 ml\/min\/1.73m2\/year, P=0.038). Multivariable analyses identified diabetes (\u03b2=-3.85, 95%CI: -7.24--0.47, P=0.026), hypertension, microalbuminuria, and higher body mass index as independent risk factors. An exploratory subgroup analysis showed that IFG donors with baseline eGFR &amp;lt;90 mL\/min\/1.73m2 had a steeper eGFR slope compared to those with eGFR \u226590 ml\/min\/1.73m2 (P=0.004). Additional meta-analyses suggested that donors with dysglycemia may have worse renal function (P=0.036) and a higher incidence of hypertension (P=0.031) with high heterogeneity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pre-donation diabetes may increase post-nephrectomy renal risk, while IFG alone may be safe unless accompanied by reduced baseline eGFR. Notably, these hypothesis-generating findings are limited by the small sample size of the diabetic and IFG groups, and relatively short follow-up. Large multicenter cohorts with decades-long follow-up are still required.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/joneph\/aajag254","type":"journal-article","created":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T12:00:57Z","timestamp":1790769657000},"source":"Crossref","is-referenced-by-count":0,"title":["Post-Nephrectomy Renal Outcomes in Living Kidney Donors with Diabetes and Prediabetes: A Retrospective Cohort Study"],"prefix":"10.1093","author":[{"given":"Saifu","family":"Yin","sequence":"first","affiliation":[{"name":"Kidney Transplantation Ward, West China Hospital, Sichuan University"},{"name":"West China School of Nursing, Sichuan University"},{"name":"Department of Urology\/Institute of Urology, West China Hospital, Sichuan University"},{"name":"Kidney Transplantation Center, West China Hospital, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Kidney Transplantation Ward, West China Hospital, Sichuan University"},{"name":"West China School of Nursing, Sichuan University"},{"name":"Department of Urology\/Institute of Urology, West China Hospital, Sichuan University"},{"name":"Kidney Transplantation Center, West China Hospital, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenxia","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of General Practice, West China Hospital, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xia","family":"Huang","sequence":"additional","affiliation":[{"name":"Kidney Transplantation Ward, West China Hospital, Sichuan University"},{"name":"West China School of Nursing, Sichuan University"},{"name":"Department of Urology\/Institute of Urology, West China Hospital, Sichuan University"},{"name":"Kidney Transplantation Center, West China Hospital, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Luo","sequence":"additional","affiliation":[{"name":"Kidney Transplantation Ward, West China Hospital, Sichuan University"},{"name":"West China School of Nursing, Sichuan University"},{"name":"Department of Urology\/Institute of Urology, West China Hospital, Sichuan University"},{"name":"Kidney Transplantation Center, West China Hospital, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Systems Epidemiology, West China School of Public Health and West China Fourth Hospital, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, West China Hospital, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turun","family":"Song","sequence":"additional","affiliation":[{"name":"Kidney Transplantation Ward, West China Hospital, Sichuan University"},{"name":"Department of Urology\/Institute of Urology, West China Hospital, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2166-2217","authenticated-orcid":false,"given":"Tao","family":"Lin","sequence":"additional","affiliation":[{"name":"Kidney Transplantation Ward, West China Hospital, Sichuan University"},{"name":"Department of Urology\/Institute of Urology, West China Hospital, Sichuan University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,1]]},"container-title":["Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/joneph\/advance-article-pdf\/doi\/10.1093\/joneph\/aajag254\/71547749\/aajag254.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/joneph\/advance-article-pdf\/doi\/10.1093\/joneph\/aajag254\/71547749\/aajag254.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T08:14:14Z","timestamp":1790842454000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/joneph\/advance-article\/doi\/10.1093\/joneph\/aajag254\/8857678"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,1]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/joneph\/aajag254","relation":{},"ISSN":["1121-8428","1724-6059"],"issn-type":[{"value":"1121-8428","type":"print"},{"value":"1724-6059","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,1]]},"article-number":"aajag254"}}