{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T10:02:06Z","timestamp":1768989726972,"version":"3.49.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T00:00:00Z","timestamp":1734307200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100000056","name":"National Institute of Nursing Research","doi-asserted-by":"publisher","award":["R21 NR017312"],"award-info":[{"award-number":["R21 NR017312"]}],"id":[{"id":"10.13039\/100000056","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["R01DK118752"],"award-info":[{"award-number":["R01DK118752"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["U01 DK108334"],"award-info":[{"award-number":["U01 DK108334"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD086978"],"award-info":[{"award-number":["R01HD086978"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Spanish Ministry of Science and Innovation","doi-asserted-by":"publisher","award":["RYC2018-024722-I"],"award-info":[{"award-number":["RYC2018-024722-I"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>Reports of pain clinical trials evaluating psychological treatments often lack sufficient details on the potential and actual harm resulting from intervention. We aimed to understand how frequent and intense treatment reactions, conceptualized as unwanted symptoms, were in three clinical trials of digital Cognitive Behavioral Therapy (CBT) for adolescents with: (1) chronic primary pain, (2) sickle cell disease, and (3) chronic pancreatitis. We also aimed to understand any differences by demographic and clinical variables.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Method<\/jats:title>\n                  <jats:p>Analyses were conducted with 246 youths (12\u201318\u2009years old) experiencing chronic pain and one of their caregivers. 66% of the total sample was female. The number, intensity, and type of treatment reactions experienced were assessed post treatment. T-tests and Chi-squared tests were conducted to explore whether certain treatment reactions were more frequent as a function of baseline or clinical characteristics.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>9% of participants experienced some negative treatment reaction. The average intensity of those events was very low on a 0\u20133 scale (M\u2009=\u20090.1, SD\u2009=\u20090.4). There were no differences in the prevalence or intensity as a function of participant\u2019s sex, age, race, or baseline pain intensity. However, baseline anxiety [t\u2009=\u2009\u22122.4 (244); p\u2009&amp;lt;\u2009.05] and baseline pain interference [t\u2009=\u2009\u22122.2 (223); p\u2009&amp;lt;\u2009.05] were significantly higher in those who experienced negative treatment reactions.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A small number of participants reported experiencing negative treatment reactions, with a low intensity level. Those experiencing negative treatment reactions showed higher baseline anxiety and pain interference. Future research may build from our example to standardize collection of harms data in trials of psychological interventions.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpepsy\/jsae099","type":"journal-article","created":{"date-parts":[[2024,10,27]],"date-time":"2024-10-27T00:18:55Z","timestamp":1729988335000},"page":"790-797","source":"Crossref","is-referenced-by-count":2,"title":["Unwanted or negative treatment reactions in digital psychological interventions for adolescents with chronic pain"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2517-6948","authenticated-orcid":false,"given":"Roc\u00edo","family":"de la Vega","sequence":"first","affiliation":[{"name":"Department of Personality, Assessment, and Psychological Treatment, Faculty of Psychology and Speech Therapy, University of M\u00e1laga , M\u00e1laga,","place":["Spain"]},{"name":"Instituto de Investigaci\u00f3n Biom\u00e9dica de M\u00e1laga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND) , M\u00e1laga,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaylee","family":"Yokoyama","sequence":"additional","affiliation":[{"name":"Center for Child Health, Behavior and Development, Seattle Children\u2019s Research Institute , Seattle, WA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"Daniels","sequence":"additional","affiliation":[{"name":"Center for Child Health, Behavior and Development, Seattle Children\u2019s Research Institute , Seattle, WA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6036-6715","authenticated-orcid":false,"given":"Tonya M","family":"Palermo","sequence":"additional","affiliation":[{"name":"Center for Child Health, Behavior and Development, Seattle Children\u2019s Research Institute , Seattle, WA,","place":["United States"]},{"name":"Department of Anesthesiology 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