{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T10:40:04Z","timestamp":1790073604317,"version":"4.0.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T00:00:00Z","timestamp":1748217600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100012524","name":"American Lebanese Syrian Associated Charities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012524","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Clinician Scientist Development","award":["CSDG-22-102-01-CPSH"],"award-info":[{"award-number":["CSDG-22-102-01-CPSH"]}]},{"DOI":"10.13039\/100000048","name":"American Cancer Society","doi-asserted-by":"publisher","award":["R25CA23944"],"award-info":[{"award-number":["R25CA23944"]}],"id":[{"id":"10.13039\/100000048","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Children with cancer increasingly undergo germline genetic testing to identify genetic predispositions and inform clinical care options. Parents of children with pathogenic\/likely pathogenic (P\/LP) germline results have reported more distress than parents of children with negative results. Little is known about modifiable risk and resilience factors for intervention, such as cognitive perceptions. This study examined the moderating effects of parents\u2019 cognitive perceptions on adjustment to their child\u2019s germline genetic test results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Parents (N\u2009=\u2009191) completed surveys reporting cognitive perceptions (i.e., intolerance of uncertainty, symptom attributions, and perceptions of child physical vulnerability) and psychological adjustment 1\u20133.99\u2009years post-disclosure of their child\u2019s genetic test results. Moderation analyses examined whether parents\u2019 cognitive perceptions moderated the relation between children's cancer predisposition genetic testing results (P\/LP, uncertain [VUS], or negative) and parental psychological adjustment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Moderation analyses revealed significant interactions between genetic test results and both intolerance of uncertainty and psychological attributions for children\u2019s symptoms. Specifically, parents of children with P\/LP results endorsed significantly more distress and uncertainty compared to each VUS and negative results, only in cases of moderate to high intolerance of uncertainty and psychological attributions (distress outcomes). In contrast, somatic attributions for symptoms and perceived child vulnerability were directly associated with higher distress regardless of results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Cognitions such as intolerance of uncertainty and psychological symptom attribution may contribute to distress among parents of children with P\/LP results. Therefore, cognitive interventions (e.g., Cognitive Behavioral Therapy, Acceptance and Commitment Therapy) may help parents manage distress regarding their child\u2019s genetic cancer risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpepsy\/jsaf026","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T05:11:43Z","timestamp":1742706703000},"page":"195-205","source":"Crossref","is-referenced-by-count":5,"title":["The moderating role of parental cognitive perceptions in the link between children\u2019s cancer predisposition genetic testing results and parent psychological adjustment"],"prefix":"10.1093","volume":"51","author":[{"given":"Leila","family":"Sachner","sequence":"first","affiliation":[{"name":"Department of Psychology and Biobehavioral Sciences, St. Jude Children\u2019s Research Hospital , Memphis, TN,","place":["United States"]},{"name":"Department of Psychology, University of Mississippi , Oxford, MS,","place":["United 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