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Physical activity is recommended for pediatric chronic pain and is safe, feasible, and beneficial for individuals with SCD, yet uptake is limited. This study describes the adolescent- and caregiver-centered lived experience of physical activity within the context of SCD and chronic pain to inform intervention targets.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adolescents aged 12\u201318 years with any SCD genotype and medium or greater risk of chronic pain (Pediatric Pain Screening Tool) were recruited across two sites for an intervention development study. Semi-structured interviews elicited perspectives related to physical activity and its role in pain management. A deductive-inductive approach was used with the Fear Avoidance Model as an analytic framework.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Adolescents (n = 12; 15.1 \u00b1 1.5 years) were Black\/African American, even sex distribution, with 92% Medicaid-covered. Caregivers (n = 12; 39.4 \u00b1 5.8 years) were Black\/African American, and 100% were mothers\/stepmothers. Physical activity facilitators included structured social activities and older age. Barriers included triggering or worsening pain and safety concerns expressed by caregivers and adults. Caregivers emphasized that adolescents developing self-awareness helps them modify physical activity to prevent pain. Benefits of physical activity to manage pain included minimizing stiffness and pain exacerbation and sustained pain reduction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Physical activity to manage chronic SCD pain may require individualization and adaptation to address patient and caregiver concerns. Future intervention targets need to address unique facilitators and barriers, minimize challenges, and promote benefits of physical activity for chronic SCD pain.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpepsy\/jsaf055","type":"journal-article","created":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T20:18:44Z","timestamp":1753215524000},"page":"1079-1087","source":"Crossref","is-referenced-by-count":2,"title":["Physical activity among adolescents and young adults living with chronic pain and sickle cell disease: a qualitative examination"],"prefix":"10.1093","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5632-4958","authenticated-orcid":false,"given":"Jan T","family":"Mooney","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Emory University School of Medicine , Atlanta, GA,","place":["United States"]},{"name":"Aflac Cancer and Blood Disorders Center, Children\u2019s Healthcare of Atlanta , Atlanta, GA,","place":["United 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GA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory D","family":"Myer","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Emory University School of Medicine , Atlanta, GA,","place":["United States"]},{"name":"Emory Sports Performance and Research Center , Flowery Branch, GA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Trisha","family":"Kesar","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine, Emory University School of Medicine , Atlanta, GA,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles T","family":"Quinn","sequence":"additional","affiliation":[{"name":"Cincinnati Children\u2019s Hospital Medical Center, University of Cincinnati College of Medicine , Cincinnati, OH,","place":["United 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