{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:36:27Z","timestamp":1790804187327,"version":"4.1.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,1,6]],"date-time":"2020-01-06T00:00:00Z","timestamp":1578268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Australian Research Training Program Scholarship"},{"name":"Macquarie University Research Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The aim of this systematic review and meta-analysis was to provide an estimate of the prevalence of anxiety and depressive disorders in youth with epilepsy (YWE). It also aimed to calculate the overall magnitude of observed differences in anxiety and depressive symptoms reported by YWE compared with healthy controls and investigate whether any factors moderated anxiety and depression outcomes in YWE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Following prospective registration, electronic databases were searched up until October 2018. Studies were included if they reported on the rate of anxiety or depression in samples of YWE, and\/or if they used valid measures of anxious or depressive symptomatology in YWE compared with a healthy control sample.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Twenty-three studies met inclusion criteria. The overall pooled prevalence of anxiety disorders in YWE was 18.9% (95% confidence interval [CI] 12.0%\u201328.5%), and for depression the pooled prevalence was 13.5% (95% CI 8.8%\u201320.2%). In samples of YWE compared with healthy controls, significantly higher anxiety (d\u2009=\u20090.57, 95% CI 0.32\u20130.83, p\u2009&amp;lt;\u2009.000) and depressive (d\u2009=\u20090.42, 95% CI 0.16\u20130.68, p\u2009&amp;lt;\u2009.000) symptomatology was reported.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>YWE report anxiety and depressive disorders and symptoms to a significantly higher degree than youth without epilepsy. There is also evidence that certain anxiety disorders (e.g. generalized anxiety disorder, separation anxiety disorder) are particularly elevated, perhaps reflecting the unique impact of epilepsy on youth psychopathology. Research is needed to understand the risk factors associated with anxiety and depressive disorders in epilepsy, and better understand how these symptoms change across development.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpepsy\/jsz099","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T12:11:08Z","timestamp":1575547868000},"page":"133-144","source":"Crossref","is-referenced-by-count":85,"title":["Systematic Review and Meta-Analysis of Anxiety and Depression in Youth With Epilepsy"],"prefix":"10.1093","volume":"45","author":[{"given":"Amelia J","family":"Scott","sequence":"first","affiliation":[{"name":"School of Psychology, University of Sydney"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Sharpe","sequence":"first","affiliation":[{"name":"School of Psychology, University of Sydney"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Max","family":"Loomes","sequence":"first","affiliation":[{"name":"School of Psychology, University of Sydney"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena","family":"Gandy","sequence":"first","affiliation":[{"name":"Department of Psychology, eCentreClinic, Macquarie University"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,1,6]]},"reference":[{"key":"2020021907493143100_jsz099-B1","author":"Achenbach","year":"1983"},{"key":"2020021907493143100_jsz099-B2","first-page":"153","article-title":"Psychiatric morbidity in Nigerian adolescents with epilepsy","volume":"3","author":"Adewuya","year":"2005","journal-title":"Journal of Pediatric Neurology"},{"key":"2020021907493143100_jsz099-B3","volume-title":"Diagnostic and statistical manual of mental disorders","year":"2013","edition":"5th edn"},{"key":"2020021907493143100_jsz099-B44","first-page":"209","article-title":"Psychiatric and neurocognitive evaluation focused on frontal lobe functions in rolandic epilepsy","volume":"50","author":"Ayaz","year":"2013","journal-title":"N\u00f6ro Psikiyatri Ar\u015fivi"},{"key":"2020021907493143100_jsz099-B45","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.yebeh.2005.03.011","article-title":"Impact of epilepsy in adolescence: a UK controlled study","volume":"6","author":"Baker","year":"2005","journal-title":"Epilepsy & Behavior"},{"key":"2020021907493143100_jsz099-B4","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.yebeh.2010.12.038","article-title":"Psychiatric and neurodevelopmental disorders in childhood-onset epilepsy","volume":"20","author":"Berg","year":"2011","journal-title":"Epilepsy & Behavior"},{"key":"2020021907493143100_jsz099-B5","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.yebeh.2017.12.031","article-title":"Psychiatric symptoms and health-related quality of life in children with epilepsy and their mothers","volume":"80","author":"Bilgic","year":"2018","journal-title":"Epilepsy & Behavior"},{"key":"2020021907493143100_jsz099-B6","first-page":"909","article-title":"Phenobarbital treatment and major depressive disorder in children with epilepsy","volume":"80","author":"Brent","year":"1987","journal-title":"Pediatrics"},{"key":"2020021907493143100_jsz099-B46","doi-asserted-by":"crossref","first-page":"424","DOI":"10.3109\/08039488.2016.1143029","article-title":"Anxiety in adolescent epilepsy. 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