{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,24]],"date-time":"2025-07-24T11:51:14Z","timestamp":1753357874836},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,5,25]],"date-time":"2020-05-25T00:00:00Z","timestamp":1590364800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Children with perinatally acquired human immunodeficiency virus (PHIV) face a lifetime of combination antiretroviral treatment that often includes dolutegravir (DTG). DTG, an integrase strand inhibitor that has been linked to weight gain in adults, is increasingly being used in children. Understanding its potential short- and long-term sequelae in children is critically important. We report a case of excessive weight gain in a child with PHIV on DTG and provide a brief literature review.<\/jats:p>","DOI":"10.1093\/jpids\/piaa052","type":"journal-article","created":{"date-parts":[[2020,5,7]],"date-time":"2020-05-07T19:09:24Z","timestamp":1588878564000},"page":"373-375","source":"Crossref","is-referenced-by-count":6,"title":["Excessive Weight Gain Associated With Dolutegravir Initiation in a 10-Year-Old Female With Perinatally Acquired Human Immunodeficiency Virus: A Case Report and Review of the Literature"],"prefix":"10.1093","volume":"10","author":[{"given":"J","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E H","family":"Yusuf","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A L","family":"Agwu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,5,25]]},"reference":[{"key":"2021040614492848200_CIT0001","volume-title":"Growth and \\your 6- to 12-year-old","author":"Gavin","year":"2019"},{"key":"2021040614492848200_CIT0002","volume-title":"CDC growth chart: United States: weight-for-age percentiles: girls, 2 to 20 years","author":"Centers for Disease Control and Prevention"},{"key":"2021040614492848200_CIT0003","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/QAI.0000000000001525","article-title":"Brief report: weight gain in persons with HIV switched from efavirenz-based to integrase strand transfer inhibitor-based regimens","volume":"76","author":"Norwood","year":"2017","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2021040614492848200_CIT0004","volume-title":"ADVANCE study provides evidence for shift to dolutegravir containing ART. Science Daily","author":"University of the Witwatersrand","year":"2019"},{"key":"2021040614492848200_CIT0005","first-page":"ciz999","article-title":"Weight gain following initiation of antiretroviral therapy: risk factors in randomized comparative clinical trials","author":"Sax","journal-title":"Clin Infect Dis"},{"key":"2021040614492848200_CIT0006","article-title":"Greater weight gain among treatment-na\u00efve persons starting integrase inhibitors","author":"Bourgi"},{"key":"2021040614492848200_CIT0007","article-title":"Long-term safety and efficacy of dolutegravir in treatment-experienced adolescents with human immunodeficiency virus infection: results of the IMPAACT P1093 study","author":"Rolando","journal-title":"J Pediatr Infect Dis Soc"},{"key":"2021040614492848200_CIT0008","article-title":"Bictegravir\/FTC\/TAF single-tablet regiment in adolescents & children: week 48 results","author":"Gaur"},{"key":"2021040614492848200_CIT0009","volume-title":"IMPAACT 1093: dolutegravir in 6- to 12-year-old HIV-infected children: 48-week results. 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Abstract number: 816","author":"Wiznia","year":"2016"},{"key":"2021040614492848200_CIT0010","doi-asserted-by":"crossref","first-page":"e0226924","DOI":"10.1371\/journal.pone.0226924","article-title":"HIV antiretroviral drugs, dolutegravir, maraviroc and ritonavir-boosted atazanavir use different pathways to affect inflammation, senescence and insulin sensitivity in human coronary endothelial cells","volume":"15","author":"Auclair","year":"2020","journal-title":"PLoS One"},{"key":"2021040614492848200_CIT0011","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1093\/cid\/ciz407","article-title":"Greater weight gain in treatment-naive persons starting dolutegravir-based antiretroviral therapy","volume":"70","author":"Bourgi","year":"2020","journal-title":"Clin Infect Dis"},{"key":"2021040614492848200_CIT0012","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1136\/bmj.320.7240.967","article-title":"Association between postnatal catch-up growth and obesity in childhood: prospective cohort study","volume":"320","author":"Ong","year":"2000","journal-title":"BMJ"}],"container-title":["Journal of the Pediatric Infectious Diseases Society"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/jpids\/article-pdf\/10\/3\/373\/36872631\/piaa052.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/jpids\/article-pdf\/10\/3\/373\/36872631\/piaa052.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,4,6]],"date-time":"2021-04-06T15:19:52Z","timestamp":1617722392000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpids\/article\/10\/3\/373\/5843691"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,25]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2020,5,25]]},"published-print":{"date-parts":[[2021,4,3]]}},"URL":"https:\/\/doi.org\/10.1093\/jpids\/piaa052","relation":{},"ISSN":["2048-7207"],"issn-type":[{"value":"2048-7207","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,3,1]]},"published":{"date-parts":[[2020,5,25]]}}}