{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T18:25:22Z","timestamp":1750098322934},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Severe drug hypersensitivity reactions to antibiotics are rare but trimethoprim-sulfamethoxazole (TMP-SMX) is uniquely associated with numerous and varied manifestations including a reaction resembling septic shock, first observed in human immunodeficiency virus (HIV)\/AIDS patients. Over the past 25 years about 20 cases have been reported and an association with the virus and related immune system dysregulation was assumed. However, recent reports in adults have recognized similar shock-like reactions in non-HIV infected individuals. Here we review severe TMP-SMX hypersensitivity reactions and within the context of these known reactions, describe three non-HIV infected adolescent patients with shock-like reactions to TMP-SMX observed in one institution over 1.5 years.<\/jats:p>","DOI":"10.1093\/jpids\/piaa100","type":"journal-article","created":{"date-parts":[[2020,8,18]],"date-time":"2020-08-18T20:08:12Z","timestamp":1597781292000},"page":"382-385","source":"Crossref","is-referenced-by-count":4,"title":["Atypical Severe Shock-like Reactions in Adolescents After Trimethoprim-Sulfamethoxazole Therapy"],"prefix":"10.1093","volume":"10","author":[{"given":"Jennifer A","family":"Rathe","sequence":"first","affiliation":[{"name":"Division of Infectious Disease, Department of Pediatrics, Seattle Children\u2019s Hospital, University of Washington, Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Poole","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Pediatrics, Seattle Children\u2019s Hospital, University of Washington, Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ann","family":"Melvin","sequence":"additional","affiliation":[{"name":"Division of Infectious Disease, Department of Pediatrics, Seattle Children\u2019s Hospital, University of Washington, Seattle, Washington, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"2021040614481599400_CIT0001","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S1081-1206(10)60415-2","article-title":"Allergies to sulfonamide antibiotics and sulfur-containing drugs","volume":"100","author":"Dibbern","year":"2008","journal-title":"Ann Allergy Asthma Immunol"},{"key":"2021040614481599400_CIT0002","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jaci.2012.10.003","article-title":"Allergy to 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