{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T11:15:40Z","timestamp":1760267740439,"version":"3.37.3"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,9,20]],"date-time":"2020-09-20T00:00:00Z","timestamp":1600560000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["390900677"],"award-info":[{"award-number":["390900677"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 infection is a severe complication of coronavirus disease 2019. Since impaired coagulation and thrombosis\/endotheliitis are suspected pathomechanisms, we treated 2 patients with defibrotide, a profibrinolytic, antithrombotic, antiinflammatory oligonucleotide. Symptoms resolved during treatment. Moreover, coagulation parameters indicating hypofibrinolysis and complement activation normalized.<\/jats:p><jats:p>The pediatric inflammatory multisystem syndrome temporally associated with severe acute respiratory syndrome coronavirus 2 infection is a severe complication of coronavirus disease 2019. Since impaired coagulation and thrombosis\/endotheliitis are suspected pathomechanisms, 2 patients received defibrotide, a profibrinolytic, antithrombotic, antiinflammatory oligonucleotide. Symptoms resolved and hypofibrinolysis\/complement activation normalized during treatment.<\/jats:p>","DOI":"10.1093\/jpids\/piaa117","type":"journal-article","created":{"date-parts":[[2020,9,16]],"date-time":"2020-09-16T13:25:59Z","timestamp":1600262759000},"page":"622-625","source":"Crossref","is-referenced-by-count":15,"title":["Defibrotide for the Treatment of Pediatric Inflammatory Multisystem Syndrome Temporally Associated With Severe Acute Respiratory Syndrome Coronavirus 2 Infection in 2 Pediatric Patients"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7737-2142","authenticated-orcid":false,"given":"Peter","family":"Lang","sequence":"first","affiliation":[{"name":"Children\u2019s University Hospital, Eberhard Karls University Tuebingen, Tuebingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Eichholz","sequence":"additional","affiliation":[{"name":"Children\u2019s University Hospital, Eberhard Karls University Tuebingen, Tuebingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamam","family":"Bakchoul","sequence":"additional","affiliation":[{"name":"Institute of Transfusion Medicine, Eberhard Karls University Tuebingen, Tuebingen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Streiter","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital, SLK-Kliniken Heilbronn GmbH, Heilbronn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maurice","family":"Petrasch","sequence":"additional","affiliation":[{"name":"Children\u2019s Hospital, SLK-Kliniken Heilbronn GmbH, Heilbronn, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"B\u00f6sm\u00fcller","sequence":"additional","affiliation":[{"name":"Institute of Pathology, Eberhard Karls University Tuebingen, Tuebingen, 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