{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:03:45Z","timestamp":1773792225793,"version":"3.50.1"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,1,4]],"date-time":"2021-01-04T00:00:00Z","timestamp":1609718400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Avant Doctors"},{"DOI":"10.13039\/501100001794","name":"The University of Queensland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001794","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Australian National Health and Medical Research Council","award":["APP1133366"],"award-info":[{"award-number":["APP1133366"]}]},{"name":"Australian National Health and Medical Research Council","award":["APP1071822"],"award-info":[{"award-number":["APP1071822"]}]},{"name":"Australian National Health and Medical Research Council","award":["APP1181054"],"award-info":[{"award-number":["APP1181054"]}]},{"DOI":"10.13039\/501100000925","name":"NHMRC","doi-asserted-by":"publisher","award":["APP1078557"],"award-info":[{"award-number":["APP1078557"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,4,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>We explored the nasal microbiota in Indigenous Australian children in relation to ear and nasal health.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In total, 103 Indigenous Australian children aged 2\u20137 years (mean 4.7 years) were recruited from 2 Queensland communities. Children\u2019s ears, nose, and throats were examined and upper respiratory tract (URT) swabs collected. Clinical histories were obtained from parents\/medical records. URT microbiota were characterized using culturomics with Matrix assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS) identification. Real-time PCR was used to quantify otopathogen (Haemophilus influenzae, Streptococcus pneumoniae, and Moraxella catarrhalis) loads and detect respiratory viruses. Data were analyzed using beta diversity measures, regression modeling, and a correlation network analysis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Children with historical\/current otitis media (OM) or URT infection (URTI) had higher nasal otopathogen detection and loads and rhinovirus detection compared with healthy children (all P &amp;lt; .04). Children with purulent rhinorrhea had higher nasal otopathogen detection and loads and rhinovirus detection (P &amp;lt; .04) compared with healthy children. High otopathogen loads were correlated in children with historical\/current OM or URTI, whereas Corynebacterium pseudodiphtheriticum and Dolosigranulum pigrum were correlated in healthy children.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Corynebacterium pseudodiphtheriticum and D. pigrum are associated with URT and ear health. The importance of the main otopathogens in URT disease\/OM was confirmed, and their role relates to co-colonization and high otopathogens loads.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpids\/piaa141","type":"journal-article","created":{"date-parts":[[2020,11,6]],"date-time":"2020-11-06T12:10:17Z","timestamp":1604664617000},"page":"468-476","source":"Crossref","is-referenced-by-count":15,"title":["Upper Respiratory Microbiota in Relation to Ear and Nose Health Among Australian Aboriginal and Torres Strait Islander Children"],"prefix":"10.1093","volume":"10","author":[{"given":"Andrea","family":"Coleman","sequence":"first","affiliation":[{"name":"Children\u2019s Health Research Centre, The University of Queensland Centre for Clinical Research, South Brisbane, Australia"},{"name":"Department of Surgery\u2014Otolaryngology, Head and Neck Surgery, Townsville University Hospital, Townsville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seweryn","family":"Bialasiewicz","sequence":"additional","affiliation":[{"name":"Australian Centre for Ecogenomics, The University of Queensland, St Lucia, Australia"},{"name":"Queensland Pediatric Infectious Diseases Laboratory, Queensland Children\u2019s Hospital, South Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn L","family":"Marsh","sequence":"additional","affiliation":[{"name":"Menzies School of Health Research, Charles Darwin University, Darwin, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Grahn H\u00e5kansson","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Ume\u00e5 University and Essum AB, Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyra","family":"Cottrell","sequence":"additional","affiliation":[{"name":"The University of Queensland Centre for Clinical Research, Herston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Wood","sequence":"additional","affiliation":[{"name":"Queensland Health Deadly Ears Program, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadeesha","family":"Jayasundara","sequence":"additional","affiliation":[{"name":"Queensland Pediatric Infectious Diseases Laboratory, Queensland Children\u2019s Hospital, South Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert S","family":"Ware","sequence":"additional","affiliation":[{"name":"Menzies Health Institute Queensland, Griffith University, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Zaugg","sequence":"additional","affiliation":[{"name":"Children\u2019s Health Research Centre, The University of Queensland Centre for Clinical Research, South Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanna E","family":"Sidjabat","sequence":"additional","affiliation":[{"name":"The University of Queensland Centre for Clinical Research, Herston, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jasmyn","family":"Adams","sequence":"additional","affiliation":[{"name":"Queensland Health Deadly Ears Program, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josephine","family":"Ferguson","sequence":"additional","affiliation":[{"name":"Queensland Health Deadly Ears Program, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew","family":"Brown","sequence":"additional","affiliation":[{"name":"Queensland Health Deadly Ears Program, Brisbane, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristian","family":"Roos","sequence":"additional","affiliation":[{"name":"ENT Department, Lundby Hospital, 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