{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:27:59Z","timestamp":1785803279679,"version":"3.56.0"},"reference-count":109,"publisher":"Oxford University Press (OUP)","issue":"Supplement_2","license":[{"start":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T00:00:00Z","timestamp":1662508800000},"content-version":"vor","delay-in-days":6,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Chronic lower respiratory tract infections are a leading contributor to morbidity and mortality in persons with cystic fibrosis (pwCF). Traditional respiratory tract surveillance culturing has focused on a limited range of classic pathogens; however, comprehensive culture and culture-independent molecular approaches have demonstrated complex communities highly unique to each individual. Microbial community structure evolves through the lifetime of pwCF and is associated with baseline disease state and rates of disease progression including occurrence of pulmonary exacerbations. While molecular analysis of the airway microbiome has provided insight into these dynamics, challenges remain including discerning not only \u201cwho is there\u201d but \u201cwhat they are doing\u201d in relation to disease progression. Moreover, the microbiome can be leveraged as a multi-modal biomarker for both disease activity and prognostication. In this article, we review our evolving understanding of the role these communities play in pwCF and identify challenges in translating microbiome data to clinical practice.<\/jats:p>","DOI":"10.1093\/jpids\/piac036","type":"journal-article","created":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T16:00:39Z","timestamp":1662566439000},"page":"S13-S22","source":"Crossref","is-referenced-by-count":39,"title":["Exploring the Cystic Fibrosis Lung Microbiome: Making the Most of a Sticky Situation"],"prefix":"10.1093","volume":"11","author":[{"given":"Christina S","family":"Thornton","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Michigan , Ann Arbor, Michigan , USA"},{"name":"Department of Medicine, Cumming School of Medicine, University of Calgary , Calgary, Alberta , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Acosta","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Immunology and Infectious Diseases, University of Calgary , Calgary, Alberta , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G","family":"Surette","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Biomedical Sciences, McMaster University , Hamilton, Ontario , Canada"},{"name":"Department of Medicine, McMaster University , Hamilton, Ontario , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3749-7930","authenticated-orcid":false,"given":"Michael D","family":"Parkins","sequence":"additional","affiliation":[{"name":"Department of Medicine, Cumming School of Medicine, University of Calgary , Calgary, Alberta , Canada"},{"name":"Department of Microbiology, Immunology and Infectious Diseases, University of Calgary , Calgary, Alberta , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,7]]},"reference":[{"key":"2022090715560066600_CIT0001","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1128\/CMR.00068-09","article-title":"The changing microbial epidemiology in cystic fibrosis","volume":"23","author":"Lipuma","year":"2010","journal-title":"Clin Microbiol Rev"},{"key":"2022090715560066600_CIT0002","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1128\/JCM.41.8.3548-3558.2003","article-title":"Bacterial diversity in cases of lung infection in cystic fibrosis patients: 16S ribosomal DNA (rDNA) length heterogeneity PCR and 16S rDNA terminal restriction fragment length polymorphism profiling","volume":"41","author":"Rogers","year":"2003","journal-title":"J Clin Microbiol"},{"key":"2022090715560066600_CIT0003","doi-asserted-by":"crossref","first-page":"15070","DOI":"10.1073\/pnas.0804326105","article-title":"A polymicrobial perspective 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