{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:44:30Z","timestamp":1787319870890,"version":"build-2736575974"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004590","name":"Central Norway Regional Health Authority","doi-asserted-by":"publisher","award":["96987\/2008"],"award-info":[{"award-number":["96987\/2008"]}],"id":[{"id":"10.13039\/501100004590","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Trondheim University Hospital","award":["13\/8985-119"],"award-info":[{"award-number":["13\/8985-119"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,5,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Human bocavirus 1 (HBoV1) is frequently codetected with other viruses, and detected in asymptomatic children. Thus, the burden of HBoV1 respiratory tract infections (RTI) has been unknown. Using HBoV1-mRNA to indicate true HBoV1 RTI, we assessed the burden of HBoV1 in hospitalized children and the impact of viral codetections, compared with respiratory syncytial virus (RSV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Over 11 years, we enrolled 4879 children &amp;lt;16 years old admitted with RTI. Nasopharyngeal aspirates were analyzed with polymerase chain reaction for HBoV1-DNA, HBoV1-mRNA, and 19 other pathogens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>HBoV1-mRNA was detected in 2.7% (130\/4850) samples, modestly peaking in autumn and winter. Forty-three percent with HBoV1 mRNA were 12\u201317 months old, and only 5% were &amp;lt;6 months old. A total of 73.8% had viral codetections. It was more likely to detect HBoV1-mRNA if HBoV1-DNA was detected alone (odds ratio [OR]: 3.9, 95% confidence interval [CI]: 1.7\u20138.9) or with 1 viral codetection (OR: 1.9, 95% CI: 1.1\u20133.3), compared to \u22652 codetections. Codetection of severe viruses like RSV had lower odds for HBoV1-mRNA (OR: 0.34, 95% CI: 0.19\u20130.61). The yearly lower RTI hospitalization rate per 1000 children &amp;lt;5 years was 0.7 for HBoV1-mRNA and 8.7 for RSV.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>True HBoV1 RTI is most likely when HBoV1-DNA is detected alone, or with 1 codetected virus. Hospitalization due to HBoV1 LRTI is 10\u201312 times less common than RSV.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpids\/piad027","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T17:03:41Z","timestamp":1682528621000},"page":"282-289","source":"Crossref","is-referenced-by-count":10,"title":["The Burden of Human Bocavirus 1 in Hospitalized Children With Respiratory Tract Infections"],"prefix":"10.1093","volume":"12","author":[{"given":"Hedda Tr\u00f8mborg","family":"Jalving","sequence":"first","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU) , Trondheim , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inger","family":"Heimdal","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU) , Trondheim , 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Arne","family":"Nordb\u00f8","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU) , Trondheim , Norway"},{"name":"Department of Medical Microbiology, St. Olavs Hospital, Trondheim University Hospital , Trondheim , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"D\u00f8llner","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU) , Trondheim , Norway"},{"name":"Children\u2019s Department, St. Olavs Hospital, Trondheim University Hospital , Trondheim , Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Christensen","sequence":"additional","affiliation":[{"name":"Department of Clinical and Molecular Medicine, Norwegian University of Science and Technology (NTNU) , Trondheim , Norway"},{"name":"Department of Medical 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