{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:50Z","timestamp":1790812850520,"version":"4.1.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T00:00:00Z","timestamp":1685059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,6,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Several reports have suggested that routine use of anaerobic blood culture bottles together with aerobic bottles may improve blood culture positivity. However, the information is still limited regarding the utility of anaerobic blood culture bottles in the pediatric intensive care unit (PICU), where bacteremia due to anaerobic bacteria is relatively rare.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective observational study was conducted at a PICU in a tertiary children\u2019s hospital in Japan from May 2016 to January 2020. Patients aged \u226415 years old with bacteremia, for which both aerobic and anaerobic blood cultures were submitted, were included in the study. We investigated whether the positive blood culture cases were from aerobic or anaerobic bottles. We also compared the amount of blood inoculated into culture bottles to determine the effect of blood volume on the rate of detection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>During the study period, a total of 276 positive blood cultures from 67 patients were included in this study. Among the paired blood culture bottles, 22.1% were positive only for the anaerobic bottles. Escherichia coli and Enterobacter cloacae were the most common pathogens that were detected in anaerobic bottles only. Obligate anaerobic bacteria were detected in 2 (0.7%) bottles. There was no significant difference in the amount of blood inoculated into aerobic and anaerobic culture bottles.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The use of anaerobic blood culture bottles in the PICU may increase the detection rate of facultative anaerobic bacteria.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpids\/piad037","type":"journal-article","created":{"date-parts":[[2023,5,26]],"date-time":"2023-05-26T11:15:51Z","timestamp":1685099751000},"page":"372-378","source":"Crossref","is-referenced-by-count":7,"title":["The Utility of Performing Anaerobic Blood Cultures in Pediatric Intensive Care Units"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1055-4405","authenticated-orcid":false,"given":"Hiroki","family":"Kato","sequence":"first","affiliation":[{"name":"Division of Critical Care Medicine, National Center for Child Health and Development , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7164-0262","authenticated-orcid":false,"given":"Kensuke","family":"Shoji","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miyuki","family":"Jinguji","sequence":"additional","affiliation":[{"name":"Division of Microbiology, Department of Clinical Laboratory Medicine, National Center for Child Health and Development , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nao","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, National Center for Child Health and Development , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Nakagawa","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine, National Center for Child Health and Development , Tokyo , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Miyairi","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Department of Medical Subspecialties, National Center for Child Health and Development , Tokyo , Japan"},{"name":"Department of Pediatrics, Hamamatsu University School of Medicine , Shizuoka , Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,5,26]]},"reference":[{"key":"2023063014364619100_CIT0001","doi-asserted-by":"crossref","first-page":"S97","DOI":"10.1093\/clinids\/23.Supplement_1.S97","article-title":"Anaerobic bacteremia","volume":"23","author":"Goldstein","year":"1996","journal-title":"Clin Infect 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