{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T15:47:43Z","timestamp":1789055263638,"version":"build-2803163510"},"reference-count":64,"publisher":"Oxford University Press (OUP)","issue":"Supplement_2","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100006513","name":"Duke Clinical Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006513","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Summer Training in Academic Research","award":["5R25HD076475-10"],"award-info":[{"award-number":["5R25HD076475-10"]}]},{"name":"NCATS Trial Innovation Network","award":["U24TR001608"],"award-info":[{"award-number":["U24TR001608"]}]},{"DOI":"10.13039\/100000071","name":"National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["HHSN275201000003I"],"award-info":[{"award-number":["HHSN275201000003I"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Pediatric Trials Network"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We examined the association between hypoglycemia and the occurrence of early onset sepsis (EOS) in premature infants admitted to the neonatal intensive care unit (NICU).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We included infants discharged from 358 NICUs between 1997 and 2020 with gestational age &amp;lt;34 weeks, \u22651 culture collected in the first 3 days of life, and \u22651 serum glucose value recorded on the day of or day prior to culture collection. We used multivariable logistic regression and inverse probability weighting (IPW) and constructed models for three definitions of hypoglycemia: American Academy of Pediatrics (AAP), Pediatric Endocrine Society, and a definition based on neurodevelopmental studies. We performed subgroup analysis in EOS episodes caused by Gram-negative and Gram-positive organisms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of the 62,178 infants and 64,559 cultures that met study inclusion criteria, 739 (1%) cultures were positive. The median (25th, 75th percentile) glucose value was 75 mg\/dL (50, 106) on the day of or day prior to a positive culture versus 70 mg\/dL (50, 95) on the day of or day prior to a negative culture. We found that hypoglycemia was not associated with the occurrence of EOS for all organisms and Gram-positive organisms, whereas there was a small but significant association between the lower AAP glucose cutoff value and EOS due to Gram-negative organisms (logistic regression: risk difference [RD] 0.24% [95% CI, 0.01-0.47]; IPW: RD 0.22% [95% CI, 0.00-0.43]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Hypoglycemia may be an early marker of EOS, particularly in episodes caused by Gram-negative organisms and when using a stricter definition of hypoglycemia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpids\/piad067","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T09:57:50Z","timestamp":1694167070000},"page":"S28-S36","source":"Crossref","is-referenced-by-count":10,"title":["Association Between Hypoglycemia and the Occurrence of Early Onset Sepsis in Premature Infants"],"prefix":"10.1093","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9196-6350","authenticated-orcid":false,"given":"Karan R","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Duke University School of Medicine, Duke University , Durham, North Carolina ,","place":["USA"]},{"name":"Duke Clinical Research Institute, Duke University School of Medicine, Duke University , Durham, North Carolina ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonam J","family":"Shah","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Duke University School of Medicine, Duke University , Durham, North Carolina ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rawan M","family":"Fayyad","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Duke University School of Medicine, Duke University , Durham, North Carolina ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toby M","family":"Turla","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Duke University School of Medicine, Duke University , Durham, North Carolina ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura M","family":"O\u2019Sullivan","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Duke University School of Medicine, Duke University , Durham, North Carolina ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Wallace","sequence":"additional","affiliation":[{"name":"Duke Clinical Research Institute, Duke University School of Medicine, Duke University , Durham, North Carolina ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reese H","family":"Clark","sequence":"additional","affiliation":[{"name":"Pediatrix Center for Research, Education, Quality, and Safety , Sunrise, Florida ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Daniel K","family":"Benjamin","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Duke University School of Medicine, Duke University , Durham, North Carolina ,","place":["USA"]},{"name":"Duke Clinical Research Institute, Duke University School of Medicine, Duke University , Durham, North Carolina ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel G","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Duke University School of Medicine, Duke University , Durham, North Carolina ,","place":["USA"]},{"name":"Duke Clinical Research Institute, Duke University School of Medicine, Duke University , Durham, North Carolina ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph P","family":"Hornik","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Duke University School of Medicine, Duke University , Durham, North Carolina ,","place":["USA"]},{"name":"Duke Clinical Research Institute, Duke University School of Medicine, Duke University , Durham, North Carolina ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,12,26]]},"reference":[{"key":"2025072805164770700_CIT0001","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1097\/INF.0b013e3181acf6bd","article-title":"Early and late onset sepsis in late preterm infants","volume":"28","author":"Cohen-Wolkowiez","year":"2009","journal-title":"Pediatr Infect Dis J"},{"key":"2025072805164770700_CIT0002","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1542\/peds.2010-2217","article-title":"Early onset neonatal sepsis: the burden of group B streptococcal and E. coli disease continues","volume":"127","author":"Stoll","year":"2011","journal-title":"Pediatrics"},{"key":"2025072805164770700_CIT0003","doi-asserted-by":"crossref","first-page":"e20162013","DOI":"10.1542\/peds.2016-2013","article-title":"Epidemiology of invasive early-onset neonatal sepsis, 2005 to 2014","volume":"138","author":"Schrag","year":"2016","journal-title":"Pediatrics"},{"key":"2025072805164770700_CIT0004","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1128\/CMR.00031-13","article-title":"Early-onset neonatal sepsis","volume":"27","author":"Simonsen","year":"2014","journal-title":"Clin Microbiol Rev"},{"key":"2025072805164770700_CIT0005","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1097\/INF.0b013e318223bad2","article-title":"The burden of invasive early-onset neonatal sepsis in the United States, 2005-2008","volume":"30","author":"Weston","year":"2011","journal-title":"Pediatr Infect Dis J"},{"key":"2025072805164770700_CIT0006","doi-asserted-by":"crossref","first-page":"e372","DOI":"10.1542\/peds.2012-3979","article-title":"Neonatal infection and 5-year neurodevelopmental outcome of very preterm infants","volume":"132","author":"Mitha","year":"2013","journal-title":"Pediatrics"},{"key":"2025072805164770700_CIT0007","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/S0378-3782(12)70019-1","article-title":"Early and late onset sepsis in very-low-birth-weight infants from a large group of neonatal intensive care units","volume":"88","author":"Hornik","year":"2012","journal-title":"Early Hum Dev"},{"key":"2025072805164770700_CIT0008","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/INF.0b013e31819587a9","article-title":"Neonatal sepsis: a major global public health challenge","volume":"28","author":"Qazi","year":"2009","journal-title":"Pediatr Infect Dis J"},{"key":"2025072805164770700_CIT0009","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.pcl.2012.12.003","article-title":"Neonatal infectious diseases: evaluation of neonatal sepsis","volume":"60","author":"Camacho-Gonzalez","year":"2013","journal-title":"Pediatr Clin North Am"},{"key":"2025072805164770700_CIT0010","doi-asserted-by":"crossref","first-page":"170","DOI":"10.4161\/viru.26906","article-title":"Neonatal sepsis: An old problem with new insights","volume":"5","author":"Shah","year":"2014","journal-title":"Virulence"},{"key":"2025072805164770700_CIT0011","doi-asserted-by":"crossref","first-page":"F350","DOI":"10.1136\/archdischild-2014-306193","article-title":"Early onset neonatal sepsis: diagnostic dilemmas and practical management","volume":"100","author":"Bedford Russell","year":"2015","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2025072805164770700_CIT0012","doi-asserted-by":"crossref","first-page":"F329","DOI":"10.1136\/archdischild-2015-309210","article-title":"Heart rate characteristic index monitoring for bloodstream infection in an NICU: a 3-year experience","volume":"101","author":"Coggins","year":"2016","journal-title":"Arch Dis Child Fetal Neonatal Ed"},{"key":"2025072805164770700_CIT0013","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1097\/INF.0b013e318256905c","article-title":"Use of the complete blood cell count in early-onset neonatal sepsis","volume":"31","author":"Hornik","year":"2012","journal-title":"Pediatr Infect Dis J"},{"key":"2025072805164770700_CIT0014","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/MOP.0b013e3283504df3","article-title":"New technologies for the rapid diagnosis of neonatal sepsis","volume":"24","author":"Srinivasan","year":"2012","journal-title":"Curr Opin Pediatr"},{"key":"2025072805164770700_CIT0015","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1542\/peds.2007-2171","article-title":"Changing patterns in neonatal Escherichia coli sepsis and ampicillin resistance in the era of intrapartum antibiotic prophylaxis","volume":"121","author":"Bizzarro","year":"2008","journal-title":"Pediatrics"},{"key":"2025072805164770700_CIT0016","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1542\/peds.2005-1707","article-title":"Reported medication use in the neonatal intensive care unit: data from a large national data set","volume":"117","author":"Clark","year":"2006","journal-title":"Pediatrics"},{"key":"2025072805164770700_CIT0017","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/MOP.0000000000000315","article-title":"Defining neonatal sepsis","volume":"28","author":"Wynn","year":"2016","journal-title":"Curr Opin Pediatr"},{"key":"2025072805164770700_CIT0018","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/S0022-3476(70)80240-2","article-title":"Hypoglycemia in neonatal sepsis","volume":"77","author":"Yeung","year":"1970","journal-title":"J Pediatr"},{"key":"2025072805164770700_CIT0019","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/S0022-3476(73)80128-3","article-title":"Glucose disappearance rate in neonatal infection","volume":"82","author":"Yeung","year":"1973","journal-title":"J Pediatr"},{"key":"2025072805164770700_CIT0020","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1177\/000992288102000604","article-title":"Rapid glucose disappearance in infants with infection","volume":"20","author":"Leake","year":"1981","journal-title":"Clin Pediatr (Phila)"},{"key":"2025072805164770700_CIT0021","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0022-3476(05)80350-6","article-title":"Early metabolic effects of sepsis in the preterm infant: lactic acidosis and increased glucose requirement","volume":"121","author":"Fitzgerald","year":"1992","journal-title":"J Pediatr"},{"key":"2025072805164770700_CIT0022","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/INF.0000000000000024","article-title":"Clinical and laboratory factors that predict death in very low birth weight infants presenting with late-onset sepsis","volume":"33","author":"Levit","year":"2014","journal-title":"Pediatr Infect Dis J"},{"key":"2025072805164770700_CIT0023","first-page":"15","article-title":"Blood glucose levels in neonatal sepsis and probable sepsis and its association with mortality","volume":"22","author":"Ahmad","year":"2012","journal-title":"J Coll Physicians Surg Pak"},{"key":"2025072805164770700_CIT0024","doi-asserted-by":"crossref","first-page":"2316","DOI":"10.1097\/CCM.0b013e3181810378","article-title":"Glucose variability and mortality in patients with sepsis","volume":"36","author":"Ali","year":"2008","journal-title":"Crit Care Med"},{"key":"2025072805164770700_CIT0025","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s13054-016-1209-5","article-title":"Chemerin in peritoneal sepsis and its associations with glucose metabolism and prognosis: a translational cross-sectional study","volume":"20","author":"Horn","year":"2016","journal-title":"Crit Care"},{"key":"2025072805164770700_CIT0026","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.ijid.2008.08.026","article-title":"Hypoglycemia associated with bacteremic pneumococcal infections","volume":"13","author":"Jan","year":"2009","journal-title":"Int J Infect Dis"},{"key":"2025072805164770700_CIT0027","doi-asserted-by":"crossref","first-page":"R189","DOI":"10.1186\/cc11674","article-title":"Mild hypoglycemia is independently associated with increased risk of mortality in patients with sepsis: a 3-year retrospective observational study","volume":"16","author":"Park","year":"2012","journal-title":"Crit Care"},{"key":"2025072805164770700_CIT0028","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/dme.12123","article-title":"The impact of hypoglycaemia on patients admitted to hospital with medical emergencies","volume":"30","author":"Tan","year":"2013","journal-title":"Diabet Med"},{"key":"2025072805164770700_CIT0029","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.clp.2010.01.016","article-title":"The Pediatrix BabySteps Data Warehouse and the Pediatrix QualitySteps improvement project system\u2014tools for \u201cmeaningful use\u201d in continuous quality improvement","volume":"37","author":"Spitzer","year":"2010","journal-title":"Clin Perinatol"},{"key":"2025072805164770700_CIT0030","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1038\/jp.2015.125","article-title":"Neonatal hypoglycemia: is 60 the new 40? The questions remain the same","volume":"36","author":"Adamkin","year":"2016","journal-title":"J Perinatol"},{"key":"2025072805164770700_CIT0031","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.jpeds.2015.02.045","article-title":"Re-evaluating \u201ctransitional neonatal hypoglycemia\u201d: mechanism and implications for management","volume":"166","author":"Stanley","year":"2015","journal-title":"J Pediatr"},{"key":"2025072805164770700_CIT0032","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1542\/peds.2010-3851","article-title":"Postnatal glucose homeostasis in late-preterm and term infants","volume":"127","author":"Adamkin","year":"2011","journal-title":"Pediatrics"},{"key":"2025072805164770700_CIT0033","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.siny.2016.08.007","article-title":"Neonatal hypoglycemia","volume":"22","author":"Adamkin","year":"2016","journal-title":"Semin Fetal Neonatal Med"},{"key":"2025072805164770700_CIT0034","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.jpeds.2015.10.066","article-title":"Outcome at 2 years after dextrose gel treatment for neonatal hypoglycemia: follow-up of a randomized trial","volume":"170","author":"Harris","year":"2016","journal-title":"J Pediatr"},{"key":"2025072805164770700_CIT0035","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1016\/j.jpeds.2012.05.022","article-title":"Incidence of neonatal hypoglycemia in babies identified as at risk","volume":"161","author":"Harris","year":"2012","journal-title":"J Pediatr"},{"key":"2025072805164770700_CIT0036","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jpeds.2015.03.057","article-title":"Recommendations from the Pediatric Endocrine Society for evaluation and management of persistent hypoglycemia in neonates, infants, and children","volume":"167","author":"Thornton","year":"2015","journal-title":"J Pediatr"},{"key":"2025072805164770700_CIT0037","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1016\/j.clp.2006.10.001","article-title":"Glucose metabolism in the late preterm infant","volume":"33","author":"Garg","year":"2006","journal-title":"Clin Perinatol"},{"key":"2025072805164770700_CIT0038","first-page":"91","article-title":"Neonatal hypoglycemia: a continuing debate in definition and management","volume":"36","author":"Stomnaroska-Damcevski","year":"2015","journal-title":"Pril (Makedon Akad Nauk Umet Odd Med Nauki)"},{"key":"2025072805164770700_CIT0039","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1210\/jc.2008-1416","article-title":"Clinical review: drug-induced hypoglycemia: a systematic review","volume":"94","author":"Murad","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"2025072805164770700_CIT0040","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1177\/1536867X0400400307","article-title":"Implementing matching estimators for average treatment effects in Stata","volume":"4","author":"Abadie","year":"2004","journal-title":"Stata Journal"},{"key":"2025072805164770700_CIT0041","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1177\/1536867X1301300301","article-title":"Estimation of multivalued treatment effects under conditional independence","volume":"13","author":"Cattaneo","year":"2013","journal-title":"Stata Journal"},{"key":"2025072805164770700_CIT0042","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s40124-014-0059-3","article-title":"The Impact of Neonatal Illness on Nutritional Requirements-One Size Does Not Fit All","volume":"2","author":"Ramel","year":"2014","journal-title":"Curr Pediatr Rep"},{"key":"2025072805164770700_CIT0043","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1053\/siny.2001.0059","article-title":"Protein and energy requirements in preterm infants","volume":"6","author":"Denne","year":"2001","journal-title":"Semin Neonatol"},{"key":"2025072805164770700_CIT0044","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1542\/peds.110.6.e69","article-title":"Effect of sepsis syndrome on neonatal oxygen consumption and energy expenditure","volume":"110","author":"Bauer","year":"2002","journal-title":"Pediatrics"},{"key":"2025072805164770700_CIT0045","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1016\/0026-0495(94)90218-6","article-title":"Decreased gluconeogenesis and increased glucose disposal without hyperinsulinemia in 10-day-old rats with endotoxic shock","volume":"43","author":"Goto","year":"1994","journal-title":"Metabolism"},{"key":"2025072805164770700_CIT0046","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/0026-0495(68)90019-X","article-title":"The impairment of glucogenesis by gram negative infection","volume":"17","author":"LaNoue","year":"1968","journal-title":"Metabolism"},{"key":"2025072805164770700_CIT0047","doi-asserted-by":"crossref","article-title":"Selected principles of perinatal\u2013neonatal glucose metabolism","author":"Cowett","DOI":"10.1016\/S1084-2756(03)00113-1"},{"key":"2025072805164770700_CIT0048","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1164\/rccm.200709-1400OC","article-title":"Insulin-like growth factor-1 improves survival in sepsis via enhanced hepatic bacterial clearance","volume":"178","author":"Ashare","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"2025072805164770700_CIT0049","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/0026-0495(90)90172-9","article-title":"Insulin-mediated glucose uptake by individual tissues during sepsis","volume":"39","author":"Lang","year":"1990","journal-title":"Metabolism"},{"key":"2025072805164770700_CIT0050","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1136\/adc.65.10.1118","article-title":"Hyperinsulinaemic hypoglycaemia in small for dates babies","volume":"65","author":"Collins","year":"1990","journal-title":"Arch Dis Child"},{"key":"2025072805164770700_CIT0051","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jpeds.2005.10.002","article-title":"Clinical features and insulin regulation in infants with a syndrome of prolonged neonatal hyperinsulinism","volume":"148","author":"Hoe","year":"2006","journal-title":"J Pediatr"},{"key":"2025072805164770700_CIT0052","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.jpedsurg.2006.10.038","article-title":"Neonatal gut barrier and multiple organ failure: role of endotoxin and proinflammatory cytokines in sepsis and necrotizing enterocolitis","volume":"42","author":"Sharma","year":"2007","journal-title":"J Pediatr Surg"},{"key":"2025072805164770700_CIT0053","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.jpeds.2005.04.037","article-title":"Cytokine elaboration in critically ill infants with bacterial sepsis, necrotizing entercolitis, or sepsis syndrome: correlation with clinical parameters of inflammation and mortality","volume":"147","author":"Harris","year":"2005","journal-title":"J Pediatr"},{"key":"2025072805164770700_CIT0054","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0022-3476(94)70264-0","article-title":"Cytokine elevations in critically ill infants with sepsis and necrotizing enterocolitis","volume":"124","author":"Harris","year":"1994","journal-title":"J Pediatr"},{"key":"2025072805164770700_CIT0055","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/0002-9343(80)90250-8","article-title":"Hypoglycemia as a manifestation of sepsis","volume":"68","author":"Miller","year":"1980","journal-title":"Am J Med"},{"key":"2025072805164770700_CIT0056","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1128\/jb.98.2.494-501.1969","article-title":"Hypoglycemic activity of endotoxin. II. Mechanism of the phenomenon in BCG-infected mice","volume":"98","author":"Shands","year":"1969","journal-title":"J Bacteriol"},{"key":"2025072805164770700_CIT0057","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/0035-9203(65)90079-9","article-title":"Hypoglycaemia in suppurative pancholangiitis due to clonorchis sinensis","volume":"59","author":"McFadzean","year":"1965","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"2025072805164770700_CIT0058","doi-asserted-by":"crossref","first-page":"42","DOI":"10.3181\/00379727-131-33800","article-title":"Hypoglycemia and its relationship to histamine sensitization in mice","volume":"131","author":"Bergman","year":"1969","journal-title":"Proc Soc Exp Biol Med"},{"key":"2025072805164770700_CIT0059","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1128\/iai.7.4.642-654.1973","article-title":"Effects of endotoxin on gluconeogenesis, glycogen synthesis, and liver glycogen synthase in mice","volume":"7","author":"McCallum","year":"1973","journal-title":"Infect Immun"},{"key":"2025072805164770700_CIT0060","doi-asserted-by":"crossref","first-page":"H342","DOI":"10.1152\/ajpheart.1981.240.3.H342","article-title":"Direct effects of gram-negative endotoxin on skeletal muscle glucose uptake","volume":"240","author":"Raymond","year":"1981","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"2025072805164770700_CIT0061","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1210\/jc.2008-0761","article-title":"Early endotoxemia increases peripheral and hepatic insulin sensitivity in healthy humans","volume":"94","author":"Sauerwein","year":"2009","journal-title":"J Clin Endocrinol Metabol"},{"key":"2025072805164770700_CIT0062","doi-asserted-by":"crossref","first-page":"471","DOI":"10.2337\/db13-0903","article-title":"Lipopolysaccharides-mediated increase in glucose-stimulated insulin secretion: involvement of the GLP-1 pathway","volume":"63","author":"Nguyen","year":"2014","journal-title":"Diabetes"},{"key":"2025072805164770700_CIT0063","doi-asserted-by":"crossref","first-page":"3634","DOI":"10.4049\/jimmunol.1700820","article-title":"Lipopolysaccharide potentiates insulin-driven hypoglycemic shock","volume":"199","author":"Hagar","year":"2017","journal-title":"J Immunol"},{"key":"2025072805164770700_CIT0064","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s12098-014-1585-2","article-title":"The Pediatrix BabySteps\u00ae data warehouse--a unique national resource for improving outcomes for neonates","volume":"82","author":"Spitzer","year":"2015","journal-title":"Indian J Pediatr"}],"container-title":["Journal of the Pediatric Infectious Diseases Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jpids\/article-pdf\/12\/Supplement_2\/S28\/54917727\/piad067.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpids\/article-pdf\/12\/Supplement_2\/S28\/54917727\/piad067.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,28]],"date-time":"2025-07-28T09:17:01Z","timestamp":1753694221000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpids\/article\/12\/Supplement_2\/S28\/7499148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,1]]},"references-count":64,"journal-issue":{"issue":"Supplement_2","published-print":{"date-parts":[[2023,12,26]]}},"URL":"https:\/\/doi.org\/10.1093\/jpids\/piad067","relation":{},"ISSN":["2048-7207"],"issn-type":[{"value":"2048-7207","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,12,1]]},"published":{"date-parts":[[2023,12,1]]}}}