{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T18:05:43Z","timestamp":1762625143252,"version":"3.37.3"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T00:00:00Z","timestamp":1697414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Optimal antituberculosis therapy is essential for favorable clinical outcomes. Peak plasma concentrations of first-line antituberculosis drugs in infants with living HIV receiving WHO-recommended dosing were low compared with reference values for adults, supporting studies on increased doses of first-line TB drugs in infants.<\/jats:p>","DOI":"10.1093\/jpids\/piad088","type":"journal-article","created":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T17:45:44Z","timestamp":1697478344000},"page":"581-585","source":"Crossref","is-referenced-by-count":2,"title":["First-Line Antituberculosis Drug Concentrations in Infants With HIV and a History of Recent Admission With Severe Pneumonia"],"prefix":"10.1093","volume":"12","author":[{"given":"Chishala","family":"Chabala","sequence":"first","affiliation":[{"name":"University of Zambia, School of Medicine , Lusaka , Zambia"},{"name":"University Teaching Hospital, Children\u2019s Hospital , Lusaka , Zambia"},{"name":"HerpeZ , Lusaka , Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5738-5528","authenticated-orcid":false,"given":"Tom G","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Radboudumc Institute for Medical Innovation (RIMI), Radboud University Medical Center , Nijmegen , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinta","family":"Moraleda","sequence":"additional","affiliation":[{"name":"Pediatric Unit for Research and Clinical Trials (UPIC), Hospital 12 de Octubre Health Research Institute (i+12), Biomedical Foundation of Hospital Universitario 12 de Octubre (FIB-H12O) , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John M","family":"Ndaferankhande","sequence":"additional","affiliation":[{"name":"Malawi-Liverpool-Wellcome Trust Clinical Research Programme, Kamuzu University of Health Sciences , Blantyre , Malawi"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivian","family":"Mumbiro","sequence":"additional","affiliation":[{"name":"University of Zimbabwe Clinical Research Centre , Harare , Zimbabwe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfeu","family":"Passanduca","sequence":"additional","affiliation":[{"name":"Universidade Eduardo Mondlane, Faculdade de Medicina , Maputo , Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Namuziya","sequence":"additional","affiliation":[{"name":"University Teaching Hospital, Children\u2019s Hospital , Lusaka , Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damalie","family":"Nalwanga","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University , Kampala , Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Musiime","sequence":"additional","affiliation":[{"name":"Department of Paediatrics and Child Health, School of Medicine, College of Health Sciences, Makerere University , Kampala , Uganda"},{"name":"Joint Clinical Research Centre , Kampala , Uganda"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alvaro","family":"Ballesteros","sequence":"additional","affiliation":[{"name":"Pediatric Unit for Research and Clinical Trials (UPIC), Hospital 12 de Octubre Health Research Institute (i+12), Biomedical Foundation of Hospital Universitario 12 de Octubre (FIB-H12O) , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3747-9265","authenticated-orcid":false,"given":"Sara","family":"Dom\u00ednguez-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Pediatric Unit for Research and Clinical Trials (UPIC), Hospital 12 de Octubre Health Research Institute (i+12), Biomedical Foundation of Hospital Universitario 12 de Octubre (FIB-H12O) , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moses","family":"Chitsamatanga","sequence":"additional","affiliation":[{"name":"University of Zimbabwe Clinical Research Centre , Harare , Zimbabwe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uneisse","family":"Cassia","sequence":"additional","affiliation":[{"name":"Universidade Eduardo Mondlane, Faculdade de Medicina , Maputo , Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bwendo","family":"Nduna","sequence":"additional","affiliation":[{"name":"Arthur Davidson Children\u2019s Hospital , Ndola , Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justina","family":"Bramugy","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade de Manhi\u00e7a , Maputo , Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jahit","family":"Sacarlal","sequence":"additional","affiliation":[{"name":"Universidade Eduardo Mondlane, Faculdade de Medicina , Maputo , Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lola","family":"Madrid","sequence":"additional","affiliation":[{"name":"Pediatric Unit for Research and Clinical Trials (UPIC), Hospital 12 de Octubre Health Research Institute (i+12), Biomedical Foundation of Hospital Universitario 12 de Octubre (FIB-H12O) , Madrid , Spain"},{"name":"London School of Hygiene and Tropical Medicine (LMC) , London , UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kusum J","family":"Nathoo","sequence":"additional","affiliation":[{"name":"University of Zimbabwe Clinical Research Centre , Harare , Zimbabwe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0389-9934","authenticated-orcid":false,"given":"Angela","family":"Colbers","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Radboudumc Institute for Medical Innovation (RIMI), Radboud University Medical Center , Nijmegen , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David M","family":"Burger","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Radboudumc Institute for Medical Innovation (RIMI), Radboud University Medical Center , Nijmegen , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Veronica","family":"Mulenga","sequence":"additional","affiliation":[{"name":"University of Zambia, School of Medicine , Lusaka , Zambia"},{"name":"University Teaching Hospital, Children\u2019s Hospital , Lusaka , Zambia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W Chris","family":"Buck","sequence":"additional","affiliation":[{"name":"Universidade Eduardo Mondlane, Faculdade de Medicina , Maputo , Mozambique"},{"name":"University of California Los Angeles, David Geffen School of Medicine , Los Angeles, California , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilda A","family":"Mujuru","sequence":"additional","affiliation":[{"name":"University of Zimbabwe Clinical Research Centre , Harare , Zimbabwe"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsey H M","family":"te Brake","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Radboudumc Institute for Medical Innovation (RIMI), Radboud University Medical Center , Nijmegen , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pablo","family":"Rojo","sequence":"additional","affiliation":[{"name":"Pediatric Unit for Research and Clinical Trials (UPIC), Hospital 12 de Octubre Health Research Institute (i+12), Biomedical Foundation of Hospital Universitario 12 de Octubre (FIB-H12O) , Madrid , Spain"},{"name":"Complutense University of Madrid , Madrid , Spain"},{"name":"Pediatric Service, Hospital Universitario 12 de Octubre, Servicio Madrile\u00f1o de Salud (SERMAS) , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2860-3455","authenticated-orcid":false,"given":"Alfredo","family":"Tagarro","sequence":"additional","affiliation":[{"name":"Pediatric Unit for Research and Clinical Trials (UPIC), Hospital 12 de Octubre Health Research Institute (i+12), Biomedical Foundation of Hospital Universitario 12 de Octubre (FIB-H12O) , Madrid , Spain"},{"name":"Pediatric Service, Infanta Sofia University Hospital, Servicio Madrile\u00f1o de Salud (SERMAS) , Madrid , Spain"},{"name":"Universidad Europea de Madrid , Madrid , Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob E","family":"Aarnoutse","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Radboudumc Institute for Medical Innovation (RIMI), Radboud University Medical Center , Nijmegen , The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"EMPIRICAL clinical trial group","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad","family":"Sidat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elias","family":"Manjate","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00f3nia","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella","family":"Langa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nat\u00e1lia","family":"Nipaco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Machava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anast\u00e2ncia","family":"Chirindza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luzidina","family":"Martins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e9rcia","family":"Nhaca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kusum J","family":"Nathoo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moses","family":"Chitsamatanga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Marange","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shepherd","family":"Mudzingwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dorothy","family":"Murungu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idah","family":"Zulu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Perfect","family":"Shankalala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mulima","family":"Mukubesa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliet","family":"Namwinwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chalwe","family":"Chibuye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terence","family":"Chipoya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bwalya","family":"Simunyola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Tembo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muleya","family":"Inambao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salome","family":"Chitondo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wyclef","family":"Mumba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Endreen","family":"Mankushe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry","family":"Musukwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davies","family":"Sondashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Kamugisha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Econi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Kiggwe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Beinomugisha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharafat","family":"Nkinzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lawrence","family":"Kakooza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henriator","family":"Namisanvu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Lajara Mark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josam Thembo","family":"Mwesige","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Segawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Ssessanga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Mbavu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bosco","family":"Kafufu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Nansera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Najjingo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bashira T","family":"Mbabazi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Lugemwa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam","family":"Kasozi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rogers","family":"Ankunda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilit","family":"Manukyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,10,16]]},"reference":[{"volume-title":"UNAIDS Data 2022","year":"2022","author":"UNAIDS","key":"2023113008274580900_CIT0001"},{"key":"2023113008274580900_CIT0002","first-page":"392","article-title":"The natural history of childhood intra-thoracic tuberculosis: a critical review of literature from the pre-chemotherapy era","volume":"8","author":"Marais","year":"2004","journal-title":"Int J Tuberc Lung Dis"},{"key":"2023113008274580900_CIT0003","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1056\/NEJMra035092","article-title":"Developmental pharmacology--drug disposition, action, and therapy in infants and children","volume":"349","author":"Kearns","year":"2003","journal-title":"N Engl J Med"},{"key":"2023113008274580900_CIT0004","doi-asserted-by":"crossref","first-page":"401","DOI":"10.5588\/ijtld.22.0591","article-title":"Adequacy of WHO weight-band dosing and fixed-dose combinations for the treatment of TB in children","volume":"27","author":"Kwara","year":"2023","journal-title":"Int J Tuberc Lung Dis"},{"key":"2023113008274580900_CIT0005","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1093\/cid\/ciab725","article-title":"Pharmacokinetics of first-line drugs in children with Tuberculosis, using World Health Organization-recommended weight band doses and formulations","volume":"74","author":"Chabala","year":"2022","journal-title":"Clin Infect Dis"},{"key":"2023113008274580900_CIT0006","doi-asserted-by":"crossref","first-page":"3433","DOI":"10.1093\/jac\/dkaa328","article-title":"Pharmacokinetics of antiretroviral and tuberculosis drugs in children with HIV\/TB co-infection: a systematic review","volume":"75","author":"Jacobs","year":"2020","journal-title":"J Antimicrob Chemother"},{"key":"2023113008274580900_CIT0007","doi-asserted-by":"crossref","first-page":"2201596","DOI":"10.1183\/13993003.01596-2022","article-title":"Global estimates and determinants of antituberculosis drug pharmacokinetics in children and adolescents: a systematic review and individual patient data meta-analysis","volume":"61","author":"Gafar","year":"2022","journal-title":"Eur Respir J"},{"key":"2023113008274580900_CIT0008","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1186\/s13063-022-06203-1","article-title":"Empirical treatment against cytomegalovirus and tuberculosis in HIV-infected infants with severe pneumonia: study protocol for a multicenter, open-label randomized controlled clinical trial","volume":"23","author":"Rojo","year":"2022","journal-title":"Trials"},{"key":"2023113008274580900_CIT0009","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/s40265-014-0222-8","article-title":"Therapeutic drug monitoring in the treatment of tuberculosis: an update","volume":"74","author":"Alsultan","year":"2014","journal-title":"Drugs"},{"volume-title":"Guidance for National Tuberculosis Programmes on the Management of Tuberculosis in Children","year":"2014","key":"2023113008274580900_CIT0010"},{"key":"2023113008274580900_CIT0011","doi-asserted-by":"crossref","first-page":"285","DOI":"10.2217\/pgs.13.230","article-title":"Full-gene sequencing analysis of NAT2 and its relationship with isoniazid pharmacokinetics in Venezuelan children with tuberculosis","volume":"15","author":"Verhagen","year":"2014","journal-title":"Pharmacogenomics"},{"key":"2023113008274580900_CIT0012","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/jac\/dkv394","article-title":"Impact of food on the pharmacokinetics of first-line anti-TB drugs in treatment-naive TB patients: a randomized cross-over trial","volume":"71","author":"Saktiawati","year":"2016","journal-title":"J Antimicrob Chemother"}],"container-title":["Journal of the Pediatric Infectious Diseases Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jpids\/advance-article-pdf\/doi\/10.1093\/jpids\/piad088\/52174474\/piad088.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpids\/article-pdf\/12\/11\/581\/53928279\/piad088.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpids\/article-pdf\/12\/11\/581\/53928279\/piad088.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,30]],"date-time":"2023-11-30T08:28:09Z","timestamp":1701332889000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpids\/article\/12\/11\/581\/7318139"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,16]]},"references-count":12,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2023,10,16]]},"published-print":{"date-parts":[[2023,11,30]]}},"URL":"https:\/\/doi.org\/10.1093\/jpids\/piad088","relation":{},"ISSN":["2048-7207"],"issn-type":[{"type":"electronic","value":"2048-7207"}],"subject":[],"published-other":{"date-parts":[[2023,11,1]]},"published":{"date-parts":[[2023,10,16]]}}}