{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T14:06:29Z","timestamp":1776866789734,"version":"3.51.2"},"reference-count":82,"publisher":"Oxford University Press (OUP)","issue":"Supplement_1","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Cytomegalovirus (CMV) is a significant cause of morbidity and mortality in pediatric transplantation. However, currently utilized CMV prevention paradigms have limitations, leading to research aimed at novel strategies for mitigation of CMV infection. Cell-mediated immunity (CMI) is crucial in controlling CMV infection and the use of CMV-specific CMI assays to guide prevention and treatment of CMV infection in both solid organ transplant and hematopoietic cell transplant recipients shows great promise. In this article, we review the immune response to CMV infection to highlight the rationale for CMI assays, describe available commercial assays and strategies for their use, and summarize relevant literature regarding the use of CMI assays in transplant recipients.<\/jats:p>","DOI":"10.1093\/jpids\/piae005","type":"journal-article","created":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T19:46:50Z","timestamp":1709149610000},"page":"S22-S30","source":"Crossref","is-referenced-by-count":6,"title":["Cytomegalovirus Cell-mediated Immunity Assays in Pediatric Transplantation"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7959-1445","authenticated-orcid":false,"given":"William R","family":"Otto","sequence":"first","affiliation":[{"name":"Division of Infectious Diseases, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, Ohio , USA"},{"name":"Department of Pediatrics, University of Cincinnati , Cincinnati, Ohio , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Surabhi B","family":"Vora","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases, Seattle Children\u2019s Hospital , Seattle, Washington , USA"},{"name":"Department of Pediatrics, University of Washington , Seattle, Washington , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel E","family":"Dulek","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Monroe Carell Jr Children\u2019s Hospital at Vanderbilt , Nashville, Tennessee , USA"},{"name":"Department of Pediatrics, Vanderbilt University Medical Center , Nashville, Tennessee , USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,2,28]]},"reference":[{"key":"2024022819461690300_CIT0001","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1097\/TP.0000000000002191","article-title":"The third international consensus guidelines on the management of cytomegalovirus in solid-organ transplantation","volume":"102","author":"Kotton","year":"2018","journal-title":"Transplantation"},{"key":"2024022819461690300_CIT0002","doi-asserted-by":"crossref","first-page":"e13977","DOI":"10.1111\/tid.13977","article-title":"Cytomegalovirus in the transplant setting: where are we now and what happens next? 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