{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T15:02:13Z","timestamp":1788447733609,"version":"build-2803163510"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health & Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000179","name":"Office of the Director","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000179","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008548","name":"Harvard T.H. Chan School of Public Health","doi-asserted-by":"publisher","award":["HD052102"],"award-info":[{"award-number":["HD052102"]}],"id":[{"id":"10.13039\/100008548","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008548","name":"Harvard T.H. Chan School of Public Health","doi-asserted-by":"publisher","award":["P01HD103133"],"award-info":[{"award-number":["P01HD103133"]}],"id":[{"id":"10.13039\/100008548","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Tulane University School of Medicine","award":["HD052104"],"award-info":[{"award-number":["HD052104"]}]},{"DOI":"10.13039\/100030692","name":"Intramural Research Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100030692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Tenofovir disoproxil fumarate (TDF) is often used in treating pregnant women living with HIV. Third-trimester TDF exposure is associated with a 12% reduction in bone mineral content in HIV-exposed uninfected (HEU) neonates. The potential mechanisms underlying this observation are unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The TDF study enrolled newborns of gestational age \u226536 weeks from the Surveillance Monitoring for Antiretroviral Therapy and Toxicities study based on in utero TDF exposure (TDF use \u22658 weeks in the third trimester vs none). Blood and urine samples were collected cross-sectionally within 30 days of birth to assess renal function (serum creatinine, serum phosphate, eGFR, percent tubular reabsorption of phosphate [PTRP]), and bone turnover (serum parathyroid hormone, 25-OH vitamin D [25(OH)D], and urinary cross-linked N-telopeptide of type 1 collagen). For each biomarker, a LOESS plot was fit using values at age at specimen collection; regression lines over age were fit among samples collected from 4 to 30 days, to compare slopes by TDF exposure.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 141 neonates, 77 were TDF-exposed and 64 TDF-unexposed. Between age 4 and 30 days, PTRP decreased more rapidly in the TDF-exposed compared to the unexposed group with slopes of \u22120.58 vs \u22120.08\/day (difference \u22120.50\/day [95% CI \u22120.88, \u22120.11]). Slopes for 25(OH)D were similar in both groups, but serum levels were lower in TDF-exposed neonates (median [IQR]: 22 [19, 29] vs 26 [22, 37] ng\/mL). No differences were observed for other biomarkers.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Third-trimester in utero exposure to TDF is associated with increased urinary loss of phosphate and lower serum concentrations of 25(OH)D in HEU neonates.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpids\/piae054","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T16:37:07Z","timestamp":1717087027000},"page":"396-405","source":"Crossref","is-referenced-by-count":4,"title":["Phosphaturia in HIV-Exposed Uninfected Neonates Associated with Maternal Use of Tenofovir Disoproxil Fumarate in Late Pregnancy"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6902-7779","authenticated-orcid":false,"given":"Murli U","family":"Purswani","sequence":"first","affiliation":[{"name":"Division of Pediatric Infectious Disease, BronxCare Health System, Icahn School of Medicine at Mount Sinai , Bronx, New York ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise L","family":"Jacobson","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research, Harvard TH Chan School of Public Health , Boston, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda A","family":"DiMeglio","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology and Diabetology, Riley Hospital for Children at IU Health, Indiana University School of Medicine , Indianapolis, Indiana ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tzy-Jyun","family":"Yao","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research, Harvard TH Chan School of Public Health , Boston, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey B","family":"Kopp","sequence":"additional","affiliation":[{"name":"Kidney Disease Section, NIDDK, NIH , Bethesda, Maryland ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell B","family":"Van Dyke","sequence":"additional","affiliation":[{"name":"Section of Pediatric Infectious Diseases, Tulane University School of Medicine , New Orleans, Louisiana ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Yu","sequence":"additional","affiliation":[{"name":"Center for Biostatistics in AIDS Research, Harvard TH Chan School of Public Health , Boston, Massachusetts ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5999-1596","authenticated-orcid":false,"given":"George K","family":"Siberry","sequence":"additional","affiliation":[{"name":"Prevention Care and Treatment Division, Office of HIV\/AIDS, United States Agency for International Development , Washington, District of Columbia ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"For the Pediatric HIV\/AIDS Cohort Study (PHACS)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Chadwick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret Ann","family":"Sanders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Malee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoonsun","family":"Pyun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary","family":"Paul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelley","family":"Buschur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chivon","family":"McMullen-Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynnette","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Murli","family":"Purswani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin","family":"Alvarado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahoobullah Mirza","family":"Baig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alma","family":"Villegas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa-Gaye","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Blood","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Garvie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dia","family":"Cooley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Borkowsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagamah Sandra","family":"Deygoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arry","family":"Dieudonne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Bettica","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Surowiec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine","family":"Knapp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamie","family":"Russell-Bell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Wilkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Love","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Rosario","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lourdes","family":"Angeli-Nieves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Olivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Kohlhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ava","family":"Dennie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Kaye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny","family":"Wallier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarita","family":"Silio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Craig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Sirois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecelia","family":"Hutto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paige","family":"Hickman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Huldtquist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Marullo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen A","family":"Spector","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Figueroa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan","family":"Loughran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon","family":"Nichols","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"McFarland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carrie","family":"Chambers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mobeen","family":"Rathore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamilah","family":"Tejan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Borestil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Staci","family":"Routman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwendolyn","family":"Scott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel","family":"Fernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anai","family":"Cuadra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toni","family":"Frederick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariam","family":"Davtyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Morales-Avendano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe M","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizmarie","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nydia","family":"Scalley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"key":"2025053020015233200_CIT0001","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s40121-015-0070-1","article-title":"Tenofovir: what we have learnt after 7.5 million person-years of use","volume":"4","author":"Ustianowski","year":"2015","journal-title":"Infect Dis Ther"},{"key":"2025053020015233200_CIT0002","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/hep.28156","article-title":"AASLD guidelines for treatment of chronic hepatitis B","volume":"63","author":"Terrault","year":"2016","journal-title":"Hepatology"},{"key":"2025053020015233200_CIT0003","author":"US Public Health Service"},{"key":"2025053020015233200_CIT0004","author":"World Health Organization"},{"key":"2025053020015233200_CIT0005","author":"Office of AIDS Research Advisory Council"},{"key":"2025053020015233200_CIT0006","author":"Office of AIDS Research Advisory Council"},{"key":"2025053020015233200_CIT0007","doi-asserted-by":"crossref","first-page":"e711","DOI":"10.1542\/peds.2005-2525","article-title":"Tenofovir disoproxil fumarate and an optimized background regimen of antiretroviral agents as salvage therapy: impact on bone mineral density in HIV-infected children","volume":"118","author":"Gafni","year":"2006","journal-title":"Pediatrics"},{"key":"2025053020015233200_CIT0008","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1310\/hct1405-224","article-title":"Bone mineral density effects of randomized regimen and nucleoside reverse transcriptase inhibitor selection from ACTG A5142","volume":"14","author":"Huang","year":"2013","journal-title":"HIV Clin Trials"},{"key":"2025053020015233200_CIT0009","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/INF.0b013e31827f4eff","article-title":"Tenofovir treatment duration predicts proteinuria in a multiethnic United States Cohort of children and adolescents with perinatal HIV-1 infection","volume":"32","author":"Purswani","year":"2013","journal-title":"Pediatr Infect Dis J"},{"key":"2025053020015233200_CIT0010","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1681\/ASN.2012080857","article-title":"Tenofovir effect on the kidneys of HIV-infected patients: a double-edged sword","volume":"24","author":"Tourret","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"2025053020015233200_CIT0011","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/QAI.0000000000001359","article-title":"Safety of tenofovir disoproxil fumarate-based antiretroviral therapy regimens in pregnancy for HIV-infected women and their infants: a systematic review and meta-analysis","volume":"76","author":"Nachega","year":"2017","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2025053020015233200_CIT0012","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1097\/QAD.0b013e328352d135","article-title":"Safety of tenofovir use during pregnancy: early growth outcomes in HIV-exposed uninfected infants","volume":"26","author":"Siberry","year":"2012","journal-title":"AIDS"},{"key":"2025053020015233200_CIT0013","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/cid\/ciy982","article-title":"Maternal and infant bone mineral density 1 year after delivery in a randomized, controlled trial of maternal tenofovir disoproxil fumarate to prevent mother-to-child transmission of hepatitis B virus","volume":"69","author":"Salvadori","year":"2019","journal-title":"Clin Infect Dis"},{"key":"2025053020015233200_CIT0014","doi-asserted-by":"crossref","first-page":"e264","DOI":"10.1097\/INF.0000000000002152","article-title":"Tenofovir disoproxil fumarate use during pregnancy and infant bone health: the tenofovir in Pregnancy Pilot Study","volume":"37","author":"Kourtis","year":"2018","journal-title":"Pediatr Infect Dis J"},{"key":"2025053020015233200_CIT0015","doi-asserted-by":"crossref","first-page":"3206","DOI":"10.1093\/jac\/dkw268","article-title":"Levels of bone markers in a population of infants exposed in utero and during breastfeeding to tenofovir within an Option B+ programme in Malawi","volume":"71","author":"Floridia","year":"2016","journal-title":"J Antimicrob Chemother"},{"key":"2025053020015233200_CIT0016","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/INF.0000000000001386","article-title":"Bone age and mineral density assessments using plain roentgenograms in tenofovir-exposed infants in Malawi and Brazil enrolled in HIV Prevention Trials Network 057","volume":"36","author":"Osorio","year":"2017","journal-title":"Pediatr Infect Dis J"},{"key":"2025053020015233200_CIT0017","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1093\/cid\/civ437","article-title":"Lower newborn bone mineral content associated with maternal use of tenofovir disoproxil fumarate during pregnancy","volume":"61","author":"Siberry","year":"2015","journal-title":"Clin Infect Dis"},{"key":"2025053020015233200_CIT0018","doi-asserted-by":"crossref","first-page":"e10","DOI":"10.1590\/s1678-9946202264010","article-title":"Tenofovir-induced renal and bone toxicity: report of two cases and literature review","volume":"64","author":"Fioroti","year":"2022","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"2025053020015233200_CIT0019","first-page":"354908","article-title":"Tenofovir nephrotoxicity: 2011 update","volume":"2011","author":"Fernandez-Fernandez","year":"2011","journal-title":"AIDS Res Treat"},{"key":"2025053020015233200_CIT0020","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1002\/jbmr.3665","article-title":"Tenofovir causes bone loss via decreased bone formation and increased bone resorption, which can be counteracted by dipyridamole in mice","volume":"34","author":"Conesa-Buendia","year":"2019","journal-title":"J Bone Miner Res"},{"key":"2025053020015233200_CIT0021","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3389\/fimmu.2016.00199","article-title":"The PHACS SMARTT Study: assessment of the safety of in utero exposure to antiretroviral drugs","volume":"7","author":"Van Dyke","year":"2016","journal-title":"Front Immunol"},{"key":"2025053020015233200_CIT0022","first-page":"1","article-title":"CDC growth charts: United States","volume":"314","author":"Kuczmarski","year":"2000","journal-title":"Adv Data"},{"key":"2025053020015233200_CIT0023","volume-title":"The Harriet Lane Handbook","author":"The John Hopkins Hospital","year":"2020","edition":"22"},{"key":"2025053020015233200_CIT0024","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1111\/j.1442-200X.2010.03086.x","article-title":"Urinary N-telopeptides of type I collagen in healthy children","volume":"52","author":"Sato","year":"2010","journal-title":"Pediatr Int"},{"key":"2025053020015233200_CIT0025","author":"Labcorp"},{"key":"2025053020015233200_CIT0026","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/MOP.0000000000000318","article-title":"Assessment of glomerular filtration rate in the neonate: is creatinine the best tool","volume":"28","author":"Filler","year":"2016","journal-title":"Curr Opin Pediatr"},{"key":"2025053020015233200_CIT0027","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3389\/fped.2020.00366","article-title":"Renal precision medicine in neonates and acute kidney injury: how to convert a cloud of creatinine observations to support clinical decisions","volume":"8","author":"Allegaert","year":"2020","journal-title":"Front Pediatr"},{"key":"2025053020015233200_CIT0028","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1152\/physrev.00014.2014","article-title":"Bone development and mineral homeostasis in the fetus and neonate: roles of the calciotropic and phosphotropic hormones","volume":"94","author":"Kovacs","year":"2014","journal-title":"Physiol Rev"},{"key":"2025053020015233200_CIT0029","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1128\/AAC.49.5.1898-1906.2005","article-title":"Selective intracellular activation of a novel prodrug of the human immunodeficiency virus reverse transcriptase inhibitor tenofovir leads to preferential distribution and accumulation in lymphatic tissue","volume":"49","author":"Lee","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"2025053020015233200_CIT0030","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1097\/QAI.0000000000000225","article-title":"Tenofovir alafenamide vs. tenofovir disoproxil fumarate in single tablet regimens for initial HIV-1 therapy: a randomized phase 2 study","volume":"67","author":"Sax","year":"2014","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2025053020015233200_CIT0031","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1007\/s00467-013-2666-6","article-title":"Developmental changes in renal tubular transport\u2014an overview","volume":"30","author":"Gattineni","year":"2015","journal-title":"Pediatr Nephrol"},{"key":"2025053020015233200_CIT0032","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/clpt.2008.201","article-title":"Population pharmacokinetics of tenofovir in HIV-1-infected pregnant women and their neonates (ANRS 12109)","volume":"85","author":"Hirt","year":"2009","journal-title":"Clin Pharmacol Ther"},{"key":"2025053020015233200_CIT0033","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1111\/hiv.12252","article-title":"Pharmacokinetics of tenofovir during pregnancy and postpartum","volume":"16","author":"Best","year":"2015","journal-title":"HIV Med"},{"key":"2025053020015233200_CIT0034","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/QAD.0000000000002730","article-title":"Detectable HIV RNA in late pregnancy associated with low tenofovir hair levels at time of delivery among women living with HIV in the United States","volume":"35","author":"Pintye","year":"2021","journal-title":"AIDS"},{"key":"2025053020015233200_CIT0035","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1093\/infdis\/jiaa398","article-title":"Extent of in utero transfer of tenofovir from mother to fetus: a paired analysis of hair specimens collected at birth from a cohort in the United States","volume":"223","author":"Pintye","year":"2021","journal-title":"J Infect Dis"},{"key":"2025053020015233200_CIT0036","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1097\/INF.0000000000000747","article-title":"Meconium tenofovir concentrations and growth and bone outcomes in prenatally tenofovir exposed HIV-uninfected children","volume":"34","author":"Himes","year":"2015","journal-title":"Pediatr Infect Dis J"},{"key":"2025053020015233200_CIT0037","first-page":"6069131","article-title":"Tenofovir disoproxil fumarate is associated with a set-point variation in the calcium-parathyroid hormone\u2013vitamin D Axis: results from a German Cohort","volume":"2018","author":"Noe","year":"2018","journal-title":"Adv Pharmacol Sci"},{"key":"2025053020015233200_CIT0038","first-page":"145","article-title":"Factors associated with vitamin D deficiency in HIV-1 infected patients on combination antiretroviral therapy: a case\u2013control study","volume":"42","author":"Calza","year":"2019","journal-title":"New Microbiol"},{"key":"2025053020015233200_CIT0039","doi-asserted-by":"crossref","first-page":"546544","DOI":"10.3389\/fped.2020.546544","article-title":"Association of protein and vitamin D intake with biochemical markers in premature osteopenic infants: a case\u2013control study","volume":"8","author":"Mohamed","year":"2020","journal-title":"Front Pediatr"},{"key":"2025053020015233200_CIT0040","doi-asserted-by":"crossref","first-page":"623","DOI":"10.3851\/IMP3269","article-title":"Tenofovir disoproxil fumarate appears to disrupt the relationship of vitamin D and parathyroid hormone","volume":"23","author":"Havens","year":"2018","journal-title":"Antivir Ther"},{"key":"2025053020015233200_CIT0041","doi-asserted-by":"crossref","first-page":"269","DOI":"10.5414\/CN108089","article-title":"Beta-trace protein may be a more suitable marker of neonatal renal function","volume":"81","author":"Filler","year":"2014","journal-title":"Clin Nephrol"},{"key":"2025053020015233200_CIT0042","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1016\/j.clinbiochem.2011.06.987","article-title":"Preliminary reference intervals for cystatin C and beta-trace protein in preterm and term neonates","volume":"44","author":"Bariciak","year":"2011","journal-title":"Clin Biochem"},{"key":"2025053020015233200_CIT0043","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1093\/infdis\/jiz369","article-title":"Use of contemporary protease inhibitors and risk of incident chronic kidney disease in persons with human immunodeficiency virus: the data collection on adverse events of anti-HIV drugs (D:A:D) Study","volume":"220","author":"Ryom","year":"2019","journal-title":"J Infect Dis"},{"key":"2025053020015233200_CIT0044","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1128\/AAC.00968-06","article-title":"Cathepsin A is the major hydrolase catalyzing the intracellular hydrolysis of the antiretroviral nucleotide phosphonoamidate prodrugs GS-7340 and GS-9131","volume":"51","author":"Birkus","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"key":"2025053020015233200_CIT0045","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1124\/mol.108.045526","article-title":"Activation of 9-[(R)-2-[[(S)-[[(S)-1-(Isopropoxycarbonyl)ethyl]amino] phenoxyphosphinyl]-methoxy]propyl]adenine (GS-7340) and other tenofovir phosphonoamidate prodrugs by human proteases","volume":"74","author":"Birkus","year":"2008","journal-title":"Mol Pharmacol"},{"key":"2025053020015233200_CIT0046","author":"World Health Organization","year":"2022"},{"key":"2025053020015233200_CIT0047","doi-asserted-by":"crossref","first-page":"115515","DOI":"10.1016\/j.bone.2020.115515","article-title":"Fractures in children and adolescents living with perinatally acquired HIV","volume":"139","author":"Jacobson","year":"2020","journal-title":"Bone"},{"key":"2025053020015233200_CIT0048","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1097\/QAI.0000000000000112","article-title":"HIV infection and its association with an excess risk of clinical fractures: a nationwide case\u2013control study","volume":"66","author":"Prieto-Alhambra","year":"2014","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2025053020015233200_CIT0049","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1097\/QAI.0000000000003218","article-title":"Bone and renal health in infants with or without breastmilk exposure to tenofovir-based maternal antiretroviral treatment in the PROMISE randomized trial","volume":"93","author":"Vhembo","year":"2023","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2025053020015233200_CIT0050","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1097\/COH.0000000000000248","article-title":"Tenofovir and bone health","volume":"11","author":"Grant","year":"2016","journal-title":"Curr Opin HIV AIDS"},{"key":"2025053020015233200_CIT0051","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1473-3099(15)00348-5","article-title":"Switching from tenofovir disoproxil fumarate to tenofovir alafenamide in antiretroviral regimens for virologically suppressed adults with HIV-1 infection: a randomised, active-controlled, multicentre, open-label, phase 3, non-inferiority study","volume":"16","author":"Mills","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"2025053020015233200_CIT0052","doi-asserted-by":"crossref","first-page":"e1229","DOI":"10.1542\/peds.2014-2173","article-title":"Optimizing bone health in children and adolescents","volume":"134","author":"Golden","year":"2014","journal-title":"Pediatrics"}],"container-title":["Journal of the Pediatric Infectious Diseases Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jpids\/advance-article-pdf\/doi\/10.1093\/jpids\/piae054\/58035132\/piae054.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpids\/article-pdf\/13\/8\/396\/58913237\/piae054.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpids\/article-pdf\/13\/8\/396\/58913237\/piae054.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T00:02:08Z","timestamp":1748649728000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpids\/article\/13\/8\/396\/7685989"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,31]]},"references-count":52,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8,24]]}},"URL":"https:\/\/doi.org\/10.1093\/jpids\/piae054","relation":{},"ISSN":["2048-7207"],"issn-type":[{"value":"2048-7207","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,8]]},"published":{"date-parts":[[2024,5,31]]}}}