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In contrast, cell-free bacterial components reaching the fetal brain from an infected mother signal a quiet, noninflammatory immune response that drives abnormal neurodevelopment, changing brain architecture through neuroproliferation. This review addresses the difference between prenatal and postnatal bacterial\u2013host signaling within the brain.<\/jats:p>","DOI":"10.1093\/jpids\/piae068","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T17:01:42Z","timestamp":1736355702000},"source":"Crossref","is-referenced-by-count":1,"title":["Interactions of the Pneumococcus with the Central Nervous System: Postnatal Meningitis Versus Fetal Neurodevelopment"],"prefix":"10.1093","volume":"14","author":[{"given":"Amy","family":"Davis","sequence":"first","affiliation":[{"name":"Department of Host-Microbe Interactions, St Jude Children\u2019s Research Hospital , Memphis, Tennessee ,","place":["USA"]},{"name":"Department of Microbiology, Immunology, and Biochemistry, University of Tennessee Health Science Center , Memphis, Tennessee ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0349-8716","authenticated-orcid":false,"given":"Elaine","family":"Tuomanen","sequence":"additional","affiliation":[{"name":"Department of Host-Microbe Interactions, St Jude Children\u2019s Research Hospital , Memphis, Tennessee ,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,1,8]]},"reference":[{"key":"2025012314291747800_CIT0001","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1097\/WCO.0000000000000934","article-title":"Acute bacterial meningitis","volume":"34","author":"Wall","year":"2021","journal-title":"Curr Opin Neurol"},{"key":"2025012314291747800_CIT0002","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0140-6736(21)00883-7","article-title":"Community acquired bacterial meningitis","volume":"398","author":"Van de beek","year":"2021","journal-title":"Lancet"},{"key":"2025012314291747800_CIT0003","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1001\/jama.2022.20521","article-title":"Progress and challenges in bacterial meningitis","volume":"328","author":"Hasbun","year":"2022","journal-title":"JAMA"},{"volume-title":"Defeating Meningitis by 2030. 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