{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:10:29Z","timestamp":1789567829121,"version":"build-2803163510"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Data on the presentation, management, and outcomes of Lassa fever (LF) in children are limited.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Description of the clinical and biological features, treatment, and outcomes of reverse transcriptase and polymerase chain reaction (RT-PCR)-confirmed LF in children aged under 15, enrolled in the LASsa fever clinical COurse and Prognostic factors in an Epidemic context (LASCOPE) prospective cohort study in Nigeria between April 2018 and February 2023.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>One hundred twenty-four children (aged under 12 months: 19; over 12 months: 105) were hospitalized with RT-PCR-confirmed LF. All received intravenous ribavirin. During follow-up, 99\/124 (80%) had fever; 71\/124 (57%) had digestive symptoms, vomiting (n\u2005=\u200556\/122, 46%) and abdominal pain (n\u2005=\u200534\/78 aged \u22655 years, 44%) more often than diarrhea (n\u2005=\u200519\/124, 15%); 17\/124 (14%) had hemorrhagic signs; 44\/112 (39%) had a hematocrit lower than 25%, of whom 32\/44 (73%) received transfusions; 44\/88 (50%) developed hypotension; 18\/112 (16.1%) developed kidney disease improving global outcome (KDIGO) \u22652 acute kidney injury; 10\/112 (8.9%) had KDIGO 3 acute kidney failure; 4\/124 (3.2%) underwent renal replacement therapy. Seven children died, including 4 aged under 12 months (case fatality rate: under 12 months\u201422%, 95% confidence interval (CI): 7%\u201348%; over 12 months\u20142.9%, 95% CI: 0.7%\u20138.7%). In univariable analysis, age (P\u2005=\u2005.003), impaired consciousness (P\u2005=\u2005.026), and Lassa RT-PCR Ct value (P\u2005=\u2005.006) were associated with Day 30 mortality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The fatality rate for children over 12 months hospitalized with LF was lower than that previously reported for adults. Hypotension and acute kidney injury were the most frequent organ dysfunctions. Bleeding was relatively infrequent. Anemia and the need for transfusion were common, the relative contribution of ribavirin-induced hemolysis being unknown.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpids\/piae083","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T22:40:10Z","timestamp":1724107210000},"page":"513-522","source":"Crossref","is-referenced-by-count":11,"title":["Presentation and Outcomes of Lassa Fever in Children in Nigeria: A Prospective Cohort Study (LASCOPE)"],"prefix":"10.1093","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7139-2687","authenticated-orcid":false,"given":"Alexandre","family":"Duvignaud","sequence":"first","affiliation":[{"name":"Global Health in the Global South Research Team\u2014University of Bordeaux, National Institute for Health and Medical Research (INSERM) UMR 1219, French Research Institute for Sustainable Development (IRD) EMR 271, Bordeaux Population Health Research Centre , Bordeaux ,","place":["France"]},{"name":"Department of Infectious Diseases and Tropical Medicine, Division of Tropical Medicine and Clinical International Health, CHU Bordeaux, H\u00f4pital Pellegrin, Place Am\u00e9lie Raba L\u00e9on , Bordeaux ,","place":["France"]},{"name":"Programme PAC-CI\/ANRS Research Site, University Hospital Centre of Treichville , Abidjan, C\u00f4te d\u2019Ivoire"},{"name":"The Alliance for International Medical Action , Dakar ,","place":["Senegal"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ijeoma C","family":"Etafo","sequence":"additional","affiliation":[{"name":"Lassa Fever Response Team, Infection Control and Research Centre, Federal Medical Centre Owo , Owo ,","place":["Nigeria"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Jaspard","sequence":"additional","affiliation":[{"name":"Global Health in the Global South Research Team\u2014University of Bordeaux, National Institute for Health and Medical Research 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