{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T13:43:04Z","timestamp":1787578984449,"version":"build-2736575974"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"The Independent Research Fund Denmark","award":["2034-00100B"],"award-info":[{"award-number":["2034-00100B"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Nervous system infections are associated with long-term risks of neurological disorders and healthcare service utilization, but little data exist on the long-term risks of enteroviral meningitis in childhood.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We performed a population-based, nationwide registry-based matched cohort study (1997-2021). We included 925 children with enteroviral meningitis aged &amp;lt;17 years, a comparison cohort, and a cohort of siblings of all individuals. To illustrate short- and long-term risks of neurological disorders, we calculated 1-year cumulative incidences and age- and sex-adjusted hazard ratios (aHRs) with 95% confidence intervals (95% CIs) during years 1-20 of follow-up. We further calculated the annual proportion of individuals using antiepileptic medication and healthcare services.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Young infants (0 to &amp;lt;90 days) and older children (\u226590 days to &amp;lt;17 years) had slightly increased short- and long-term risks of neurological disorders after enteroviral meningitis compared to comparison cohort members (1-year cumulative incidence: 1.4% vs 0.6%, and 1.5% vs 0.4%, 1-20-year adjusted hazard ratio: 2.0 [95% CI: 1.2-3.2] and 1.7 [95% CI: 1.0-2.8]). Older children had increased use of antiepileptic medication, as well as the use of health care services both before and after enteroviral meningitis, with a similar trend among their siblings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Enteroviral meningitis in childhood appears to be associated with increased risk of short- and long-term neurological morbidity, though our estimates in older children may be confounded by prior neurological morbidity or increased healthcare-seeking behavior. Our findings suggest a generally good prognosis after enteroviral meningitis, though clinicians should be aware of the risk of neurological disorders in selected patients.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/jpids\/piae125","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T20:39:28Z","timestamp":1733863168000},"source":"Crossref","is-referenced-by-count":5,"title":["Neurological Disorders and Use of Healthcare Services After Enteroviral Meningitis in Childhood: A Nationwide, Population-Based Cohort Study"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3534-9101","authenticated-orcid":false,"given":"Emma E","family":"Graham","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malte M","family":"Tetens","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7398-814X","authenticated-orcid":false,"given":"Jacob","family":"Bodilsen","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Aalborg University Hospital , Aalborg ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Aalborg University , Aalborg ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanna S","family":"Andersen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Odense University Hospital , Odense ,","place":["Denmark"]},{"name":"Research Unit of Clinical Microbiology, University of Southern Denmark , Odense ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram","family":"Dessau","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Zealand Hospital , Slagelse ,","place":["Denmark"]},{"name":"Department of Regional Health Research, University of Southern Denmark , Odense ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9324-911X","authenticated-orcid":false,"given":"Svend","family":"Ellermann-Eriksen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Aarhus University Hospital , Aarhus ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristina","family":"Franck","sequence":"additional","affiliation":[{"name":"Department of Virus and Microbiological Special Diagnostics, Statens Serum Institut , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sofie","family":"Midgley","sequence":"additional","affiliation":[{"name":"Department of Virus and Microbiological Special Diagnostics, Statens Serum Institut , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Kj\u00f8lseth","family":"M\u00f8ller","sequence":"additional","affiliation":[{"name":"Department of Regional Health Research, University of Southern Denmark , Odense ,","place":["Denmark"]},{"name":"Department of Clinical Microbiology, Vejle Hospital, University Hospital of Southern Denmark , Vejle ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex Christian","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Copenhagen University Hospital, Rigshospitalet , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lene","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Copenhagen University Hospital, Herlev Hospital , Herlev ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirstine K","family":"S\u00f8gaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aalborg University , Aalborg ,","place":["Denmark"]},{"name":"Department of Clinical Microbiology, Aalborg University Hospital , Aalborg ,","place":["Denmark"]},{"name":"Department of Clinical Epidemiology, Aarhus University Hospital , Aarhus ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"\u00d8stergaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, Copenhagen University Hospital, Hvidovre Hospital , Hvidovre ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne-Mette","family":"Lebech","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet , Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrikka","family":"Nygaard","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]},{"name":"Department of Pediatric and Adolescent Medicine, Copenhagen University Hospital, Rigshospitalet , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars H","family":"Omland","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Obel","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases, Copenhagen University Hospital, Rigshospitalet , Copenhagen ,","place":["Denmark"]},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen , Copenhagen ,","place":["Denmark"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,2,11]]},"reference":[{"key":"2025021110130679400_CIT0001","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1097\/QCO.0000000000000355","article-title":"Viral meningitis: current issues in diagnosis and treatment","volume":"30","author":"McGill","year":"2017","journal-title":"Curr Opin Infect 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