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Animal models biologically representative of congenital infection have been used to characterize the effects of cCMV on neurogenesis, brain development, and cochlear development. Murine models utilizing host transcriptional analyses have been helpful in understanding the inflammatory response to cCMV infection and have demonstrated a correlation between elevation of proinflammatory mediators and altered brain and cochlear morphology during development. In this article, we review mechanisms of neuropathogenesis in cCMV animal models, with particular focus on the role of CMV-induced neuroinflammation in the impairment of fetal brain development.<\/jats:p>","DOI":"10.1093\/jpids\/piaf021","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T08:41:40Z","timestamp":1745570500000},"source":"Crossref","is-referenced-by-count":4,"title":["Effects of Cytomegalovirus-Induced Neuroinflammation on Central Nervous System Development"],"prefix":"10.1093","volume":"14","author":[{"given":"Veronica","family":"Sanchez","sequence":"first","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Alabama at Birmingham , Birmingham, AL ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew D","family":"Smith","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Alabama at Birmingham , Birmingham, AL ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott H","family":"James","sequence":"additional","affiliation":[{"name":"Division of Pediatric Infectious Diseases, Department of Pediatrics, University of Alabama at Birmingham , Birmingham, AL ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"key":"2025042504413195300_CIT0001","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1002\/rmv.544","article-title":"New estimates of the prevalence of neurological and sensory sequelae and mortality associated with congenital cytomegalovirus infection","volume":"17","author":"Dollard","year":"2007","journal-title":"Rev Med Virol."},{"key":"2025042504413195300_CIT0002","doi-asserted-by":"publisher","first-page":"e2502","DOI":"10.1002\/rmv.2502","article-title":"Estimates of 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