{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:54:06Z","timestamp":1790621646382,"version":"4.1.0"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Although the current risk of avian influenza A\/H5N1 Virus infection in humans is low, children represent a high-risk group for severe disease as virus evolves. A\/H5N1 vaccine development, clinical trials, and implementation strategies for infants and children should be prioritized.<\/jats:p>\n               <jats:p>Highly pathogenic avian influenza A\/H5N1 Virus has been found in multiple US states since 2024. While human infection risk is currently low, children are a high-risk group for severe infection as the virus evolves. Preventive efforts should prioritize children in vaccine and therapeutic clinical trials and vaccine implementation strategies.<\/jats:p>","DOI":"10.1093\/jpids\/piaf035","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T03:10:16Z","timestamp":1745809816000},"source":"Crossref","is-referenced-by-count":3,"title":["Risk of Highly Pathogenic Avian Influenza A\/H5N1 Virus in Pediatrics"],"prefix":"10.1093","volume":"14","author":[{"given":"C Mary","family":"Healy","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Infectious Disease Section, Baylor College of Medicine , Houston, TX 77030 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,4,28]]},"reference":[{"key":"2025100907320873900_CIT0001","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1056\/NEJMoa2414610","article-title":"Highly pathogenic avian influenza A(H5N1) virus infections in humans","volume":"3","author":"Garg","year":"2025","journal-title":"N Engl J Med."},{"key":"2025100907320873900_CIT0002","doi-asserted-by":"publisher","first-page":"916","DOI":"10.1056\/NEJMe2416323","article-title":"The emerging threat of H5N1 to human health","volume":"392","author":"Ison","year":"2024","journal-title":"N Engl J Med."},{"key":"2025100907320873900_CIT0003","article-title":"H5 Bird Flu: Current situation"},{"key":"2025100907320873900_CIT0004","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15585\/mmwr.rr7305a1","article-title":"Prevention and control of seasonal influenza with vaccines: recommendations of the advisory committee on immunization practices - United States, 2024-25 influenza season","volume":"73","author":"Grohskopf","year":"2024","journal-title":"MMWR Recomm Rep"},{"key":"2025100907320873900_CIT0005","doi-asserted-by":"publisher","first-page":"e2021054593","DOI":"10.1542\/peds.2021-054593","article-title":"Proposals to accelerate novel vaccine development for children","volume":"149","author":"Permar","year":"2021","journal-title":"Pediatrics."},{"key":"2025100907320873900_CIT0006","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1093\/cid\/cis295","article-title":"H5N1 avian influenza in children","volume":"55","author":"Oner","year":"2012","journal-title":"Clin Infect Dis."},{"key":"2025100907320873900_CIT0007","doi-asserted-by":"publisher","first-page":"801","DOI":"10.1093\/infdis\/jiu548","article-title":"AS03B-adjuvanted H5N1 influenza vaccine in children 6 months through 17 years of age: a phase 2\/3 randomized, placebo-controlled, observer-blinded trial","volume":"211","author":"Kosalaraksa","year":"2015","journal-title":"J Infect Dis."},{"key":"2025100907320873900_CIT0008","doi-asserted-by":"publisher","first-page":"757","DOI":"10.1097\/INF.0000000000002345","article-title":"Safety, tolerability and immunogenicity of an MF59-adjuvanted, cell culture-derived, A\/H5N1, subunit influenza virus vaccine: results from a dose-finding clinical trial in healthy pediatric subjects","volume":"38","author":"Chanthavanich","year":"2019","journal-title":"Pediatr Infect Dis J."},{"key":"2025100907320873900_CIT0009","doi-asserted-by":"publisher","first-page":"6930","DOI":"10.1016\/j.vaccine.2021.10.010","article-title":"Antibody responses against heterologous A\/H5N1 strains for an MF59-adjuvanted cell culture-derived A\/H5N1 (aH5N1c) influenza vaccine in healthy pediatric subjects","volume":"39","author":"Chanthavanich","year":"2021","journal-title":"Vaccine."},{"key":"2025100907320873900_CIT0010","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1097\/QCO.0000000000000948","article-title":"mRNA vaccines against respiratory viruses","volume":"36","author":"Whitaker","year":"2023","journal-title":"Curr Opin Infect Dis."},{"key":"2025100907320873900_CIT0011","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1056\/NEJMp2313742","article-title":"The risks of normalizing parental vaccine hesitancy","volume":"390","author":"Higgins","year":"2024","journal-title":"N Engl J Med."},{"key":"2025100907320873900_CIT0012","doi-asserted-by":"publisher","first-page":"e2023065483","DOI":"10.1542\/peds.2023-065483","article-title":"Committee on infectious diseases, committee on practice and ambulatory medicine, committee on bioethics. strategies for improving vaccine communication and uptake","volume":"153","author":"O\u2019Leary","year":"2024","journal-title":"Pediatrics."}],"container-title":["Journal of the Pediatric Infectious Diseases Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jpids\/advance-article-pdf\/doi\/10.1093\/jpids\/piaf035\/63017649\/piaf035.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpids\/article-pdf\/14\/10\/piaf035\/63017649\/piaf035.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpids\/article-pdf\/14\/10\/piaf035\/63017649\/piaf035.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T11:32:11Z","timestamp":1760009531000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpids\/article\/doi\/10.1093\/jpids\/piaf035\/8120791"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,28]]},"references-count":12,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10,2]]}},"URL":"https:\/\/doi.org\/10.1093\/jpids\/piaf035","relation":{},"ISSN":["2048-7207"],"issn-type":[{"value":"2048-7207","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,10]]},"published":{"date-parts":[[2025,4,28]]},"article-number":"piaf035"}}