{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T16:48:43Z","timestamp":1766508523655,"version":"3.48.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100010877","name":"ViiV Healthcare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010877","id-type":"DOI","asserted-by":"publisher"}]},{"name":"U.S. National Institutes of Health\u2019s National Institute of Allergy and Infectious Diseases"},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000061","name":"Fogarty International Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000061","id-type":"DOI","asserted-by":"publisher"}]},{"name":"International Epidemiology Databases to Evaluate AIDS","award":["U01AI069907"],"award-info":[{"award-number":["U01AI069907"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We assessed levels of pro-inflammatory biomarkers as possible surrogate markers of cardiovascular disease (CVD) risk in Thai young adults with perinatally acquired HIV infection (YA-PHIV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Serum samples and baseline data from YA-PHIV enrolled in a prospective cohort study from November 2020 to July 2021 at five tertiary care hospitals in Thailand were analyzed. We measured high-sensitivity C-reactive protein (hs-CRP), soluble CD163 (sCD163), and interleukin (IL)-18 levels. Data were analyzed using nonparametric methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Among 347 YA-PHIV, 54% were female, the mean age was 21.7\u00a0\u00b1\u00a02.0 years, the median duration of antiretroviral treatment was 16.7 years (IQR 13.4-18.4), and 72 (21%) had virologic failure (HIV viral load &amp;gt;1000 copies\/mL). The hs-CRP levels were &amp;lt;1.0\u00a0mg\/L (low CVD risk) in 170 (49%), between 1.0-&amp;lt;3.0 (indicating intermediate CVD risk) in 88 (25%), and \u22653\u00a0mg\/L (indicating high CVD risk) in 89 (26%). The median IL-18 level was 82.2 pg\/mL (IQR 33.9-151.7), and sCD163 was 53.6\u00a0ng\/mL (IQR 31.1-90.1). YA-PHIV with virologic failure had a significantly higher level for all three biomarker levels than those with virologic suppression. Increasing age was associated with hs-CRP &amp;gt;3\u00a0mg\/L; males were more likely to have high levels of IL-18; no factors were associated with sCD163 level.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Increased pro-inflammatory biomarkers in YA-PHIV support the presence of ongoing inflammation, particularly in those with virologic failure. HIV care for YA-PHIV should focus on virologic control and modifiable metabolic risk factors. Active monitoring for cardiovascular manifestations in YA-PHIV risk is warranted as they age.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpids\/piaf053","type":"journal-article","created":{"date-parts":[[2025,5,29]],"date-time":"2025-05-29T07:43:21Z","timestamp":1748504601000},"source":"Crossref","is-referenced-by-count":0,"title":["Increased Pro-inflammatory Biomarkers and Cardiovascular Risk in Young Adults Living With Perinatal HIV in Thailand"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0246-8187","authenticated-orcid":false,"given":"Linda","family":"Aurpibul","sequence":"first","affiliation":[{"name":"Research Institute for Health Sciences, Chiang Mai University , Chiang Mai 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