{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T17:08:53Z","timestamp":1788455333900,"version":"build-2803163510"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T00:00:00Z","timestamp":1765756800000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"Medical Research Future Fund Investigator Grant"},{"name":"Melbourne Children\u2019s Clinician\u2013Scientist Fellowship"},{"DOI":"10.13039\/100014607","name":"Royal Children\u2019s Hospital Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100014607","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,12,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To investigate the follow-up and outcomes of HIV-exposed infants in a setting of low HIV prevalence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study design<\/jats:title>\n                    <jats:p>This was a multicenter, retrospective study of live-born infants of women known to be living with HIV, at 9 tertiary pediatric centers in Australia and New Zealand from 2009-2025. Antenatal, perinatal, and postnatal data, and outcomes at clinic visits to 18\u00a0months of age were collected, including co-morbidities, development, and HIV results.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Six hundred sixty-eight infants were born from 657 pregnancies to 530 women living with HIV. Two (0.3%) infants were HIV-infected. Regarding preventative interventions, 612\/616 (99.4%) pregnant women received combination antiretroviral (ARV) therapy, 660\/661 (99.8%) infants received ARV prophylaxis, and 543\/568 (96%) exclusively formula fed. A total of 94\/588 (16%) born &amp;lt;37\u00a0weeks, 106\/600 (18%) had birth weight &amp;lt;2500\u00a0g, and 26\/642 (4%) had congenital abnormalities. HIV polymerase chain reaction (PCR) testing was done for 621\/668 (93%) within 2\u00a0weeks, 598\/664 (90%) at 6\u00a0weeks, 582\/657 (89%) after 3\u00a0months, with a combined total of 643\/657 (98%) infants having at least one post 6-week HIV PCR result. At 18-month follow-up, 24\/426 (6%) had developmental delay and 47\/426 (11%) had at least 1 comorbidity. A total of 577\/668 (86%) infants were confirmed as HIV-negative by either negative antibody or 2 negative PCR tests over the age of 6\u00a0weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The perinatal transmission rate of 0.3% was extremely low. While the majority of infants were followed up well, the proportion of infants with developmental delay and co-morbidities highlights the need for improved engagement, even in a low-prevalence setting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/jpids\/piaf109","type":"journal-article","created":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T12:43:49Z","timestamp":1765716229000},"source":"Crossref","is-referenced-by-count":1,"title":["Follow-up and Outcomes of Infants Perinatally-exposed to HIV in a Low-prevalence Setting: The Multicenter Children\u2019s HIV Exposure Study 2"],"prefix":"10.1093","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5262-5323","authenticated-orcid":false,"given":"Penelope A","family":"Bryant","sequence":"first","affiliation":[{"name":"Infectious Diseases and Hospital-in-the-Home Departments, The Royal Children\u2019s Hospital Melbourne , Parkville, Victoria,","place":["Australia"]},{"name":"Clinical Infections, Murdoch 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