{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T05:43:35Z","timestamp":1777095815309,"version":"3.51.4"},"reference-count":5,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Investigator-Initiated Studies Program of Merck Sharp & Dohme Corp","award":["#61418"],"award-info":[{"award-number":["#61418"]}]},{"name":"Merck Sharp and Dohme Corp"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,3,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Data on the safety of the nine-valent human papillomavirus (9vHPV) vaccine in children younger than 9\u00a0years are limited. We conducted a single-center, open-label descriptive safety study of 150 healthy children aged 4\u20138\u00a0years who received dose 1 of 9vHPV. Active surveillance was performed through structured follow-up assessments, and passive surveillance for serious adverse events was conducted through 11\u00a0months post-vaccination. Local reactions were most common (35\/150; 23.3%), primarily injection-site pain and tenderness. Systemic events were uncommon and self-limited. Seven hospitalizations (7\/150; 4.7%) occurred during follow-up; none were considered related to vaccination or met criteria for unanticipated problems. No vaccine-related serious adverse events were identified. In this descriptive study, dose 1 of 9vHPV was well tolerated in this cohort. Larger studies are needed to further evaluate rare serious adverse events.<\/jats:p>","DOI":"10.1093\/jpids\/piag028","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T11:51:27Z","timestamp":1775130687000},"source":"Crossref","is-referenced-by-count":0,"title":["Safety of dose 1 of the nine-valent human papillomavirus vaccine in children aged 4\u20138\u00a0years"],"prefix":"10.1093","volume":"15","author":[{"given":"Natalie","family":"Pierre-Joseph","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Boston Medical Center , Boston, MA ,","place":["United States"]},{"name":"Department of Pediatrics, Boston University Chobanian & Avedisian School of Medicine , Boston, MA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5092-4442","authenticated-orcid":false,"given":"Vishakha","family":"Sabharwal","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Boston Medical Center , Boston, MA ,","place":["United States"]},{"name":"Department of Pediatrics, Boston University Chobanian & Avedisian School of Medicine , Boston, MA ,","place":["United States"]},{"name":"Division of Infectious Diseases, Department of Pediatrics , Boston Medical Center, Boston, MA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruchita","family":"Borgaonkar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Boston Medical Center , Boston, MA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johane","family":"Seide","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Boston Medical Center , Boston, MA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rana","family":"Mokhtar","sequence":"additional","affiliation":[{"name":"Ariadne Labs, Brigham and Women's Hospital and Harvard T.H. Chan School of Public Health , Boston, MA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hana","family":"Do","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Boston University Chobanian & Avedisian School of Medicine , Boston, MA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Boston University Chobanian & Avedisian School of Medicine , Boston, MA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekta","family":"Karkala","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Boston University Chobanian & Avedisian School of Medicine , Boston, MA ,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steve","family":"Pelton","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Boston Medical Center , Boston, MA ,","place":["United States"]},{"name":"Department of Pediatrics, Boston University Chobanian & Avedisian School of Medicine , Boston, MA ,","place":["United States"]},{"name":"Division of Infectious Diseases, Department of Pediatrics, Boston Medical Center , Boston, MA,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,4,3]]},"reference":[{"key":"2026042501114169700_ref1","doi-asserted-by":"publisher","first-page":"698","DOI":"10.15585\/mmwr.mm6832a3","article-title":"Human papillomavirus vaccination for adults: updated recommendations of the advisory committee on immunization practices","volume":"68","author":"Meites","year":"2019","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2026042501114169700_ref2","volume-title":"Toxicity Grading Scale for Healthy Adult and Adolescent Volunteers Enrolled in Preventive Vaccine Clinical Trials","author":"Food and Drug Administration","year":"2007"},{"key":"2026042501114169700_ref3","volume-title":"Division of AIDS (DAIDS) Table for Grading the Severity of Adult and Pediatric Adverse Events","author":"National Institute of Allergy and Infectious Diseases, Division of AIDS","year":"2017"},{"key":"2026042501114169700_ref4","doi-asserted-by":"publisher","first-page":"711","DOI":"10.1056\/NEJMoa1405044","article-title":"A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women","volume":"372","author":"Joura","year":"2015","journal-title":"N Engl J Med"},{"key":"2026042501114169700_ref5","first-page":"e594","article-title":"Safety and persistent immunogenicity of a quadrivalent human papillomavirus vaccine in preadolescents and adolescents","volume":"119","author":"Reisinger","year":"2007","journal-title":"Pediatrics."}],"container-title":["Journal of the Pediatric Infectious Diseases Society"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/jpids\/advance-article-pdf\/doi\/10.1093\/jpids\/piag028\/67783744\/piag028.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpids\/article-pdf\/15\/4\/piag028\/67783744\/piag028.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jpids\/article-pdf\/15\/4\/piag028\/67783744\/piag028.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T05:11:47Z","timestamp":1777093907000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jpids\/article\/doi\/10.1093\/jpids\/piag028\/8586506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":5,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,3,20]]}},"URL":"https:\/\/doi.org\/10.1093\/jpids\/piag028","relation":{},"ISSN":["2048-7207"],"issn-type":[{"value":"2048-7207","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2026,3]]},"article-number":"piag028"}}